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Extreme precipitation events exhibit an increasing trend for both the frequency and magnitude on global and regional scales and it has already proven the impact of man-made global warming on the extreme precipitation amplification. Based on the observed datasets and global climate model (GCM) output, this study has evaluated the impact from anthropogenic forcing on the trend and temporal non-uniformity (i.e. increase in unevenness or disparity) of the precipitation amounts (PRCPTOT), extremes (R95p and RX5day) and intensity (SDII) in Central Asia (CA) from 1961 to 2005. Results indicate that radiative forcing changes, mainly driven by human activities, have significantly augmented the extreme precipitation indices in CA. The median trend with the influence of anthropogenic activities for the PRCPTOT, SDII, R95p and RX5day amounted to 2.19 mm/decade, 0.019 mm/decade, 1.39 mm/decade and 0.21 mm/decade during the study period, respectively. A statistically insignificant decrease in non-uniformity was noticed for the PRCPTOT, SDII and RX5day in Central CA (CCA) and Western CA (WCA), while Eastern CA (ECA) was the only region with a statistically significant increase in non-uniformity of the PRCPTOT, SDII, R95p and RX5day by 4.22%, 3.98%, 3.73% and 3.97%, respectively from 1961 to 2005 due to anthropogenic forcing. These results reflect the difference in various regions regarding the impact of anthropogenic forcing on the non-uniformity of extreme precipitation events in CA, which might help to fully understand the role of anthropogenic forcing in the changes of the precipitation extremes in CA and contribute to the development of water resource management strategies.

The development of reference standards for nanoparticle sizing allows for cross laboratory studies and effective transfer of particle sizing methodology. To facilitate this, these reference standards must be stable upon long-term storage. Here, we examine factors that influence the properties of cross-linked albumin nanoparticles, fabricated with an ethanol desolvation method, when reconstituted from a lyophilized state. We demonstrate, with nanoparticle tracking analysis, no significant changes in mean particle diameter upon reconstitution of albumin nanoparticles fabricated with bovine serum albumin loaded with dodecanoic acid, when compared to nanoparticles fabricated with a fatty acid-free BSA. We attribute this stability to the modulation of nanoparticle charge-charge interactions at dodecanoic acid specific binding locations. Furthermore, we demonstrate this in a lyophilized state over six months when stored at − 80 °C. We also show that the reconstitution process is readily transferable between technicians and laboratories and further confirm our finding with dynamic light scattering analysis.

Preeclampsia is a common, pregnancy-specific disease and a major contributor to maternal and foetal morbidity and mortality. Some placental abnormalities, including deficient implantation, abnormal trophoblast cell function, and improper placental vascular development, are believed to lead to preeclampsia. The long noncoding RNA SPRY4-IT1 is more highly expressed in preeclamptic human placentas than in normal placentas. We assessed the role of epithelial-mesenchymal transition (EMT)-associated invasion and migration in HTR-8/SVneo trophoblast cells. Overexpression of SPRY4-IT1 suppressed trophoblast cell migration and invasion, whereas reduced expression of SPRY4-IT1 prevented the EMT process. Mechanistically, an RNA immunoprecipitation experiment showed that SPRY4-IT1 bound directly to HuR and mediated the β-catenin expression associated with EMT in HTR-8/SVneo cells. Moreover, the expression levels of genes in the WNT family, such as WNT3 and WNT5B, were changed after transfection of HTR-8/SVneo with SPRY4-IT1. Together, our results highlight the roles of SPRY4-IT1 in causing trophoblast cell dysfunction by acting through the Wnt/β-catenin pathway, and consequently in impairing spiral artery remodelling. These results suggest a new potential therapeutic target for intervention against preeclampsia.

Dynamics of vortex clusters is essential for understanding diverse superfluid phenomena. In this paper, we examine the dynamics of vortex quadrupoles in a trapped two-dimensional (2D) Bose-Einstein condensate. We find that the movement of these vortex-clusters fall into three distinct regimes which are fully described by the radial positions of the vortices in a 2D isotropic harmonic trap, or by the major radius (minor radius) of the elliptical equipotential lines decided by the vortex positions in a 2D anisotropic harmonic trap. In the “recombination” and “exchange” regimes the quadrupole structure maintains, while the vortices annihilate each other permanently in the “annihilation” regime. We find that the mechanism of the charge flipping in the “exchange” regime and the disappearance of the quadrupole structure in the “annihilation” regime are both through an intermediate state where two vortex dipoles connected through a soliton ring. We give the parameter ranges for these three regimes in coordinate space for a specific initial configuration and phase diagram of the vortex positions with respect to the Thomas-Fermi radius of the condensate. We show that the results are also applicable to systems with quantum fluctuations for the short-time evolution.