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9 results on '"Severi, Gianluca"'

2. Association of SARS-CoV-2 infection with physical activity domains and types

Author

Vanhelst, Jérémy, Srour, Bernard, Bourhis, Laurent, Charreire, Hélène, VerdotDeschasaux-Tanguy, Charlotte Mélanie, Druesne-Pecollo, Nathalie, de Edelenyi, Fabien Szabo, Allègre, Julien, Allès, Benjamin, Deschamps, Valérie, Bellicha, Alice, Fezeu, Leopold K., Galan, Pilar, Julia, Chantal, Kesse-Guyot, Emmanuelle, Hercberg, Serge, Bajos, Nathalie, Severi, Gianluca, Zins, Marie, de Lamballerie, Xavier, Carrat, Fabrice, Oppert, Jean-Michel, and Touvier, Mathilde

Published
2023
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5. The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study.

Author

Carreras-Torres, Robert, Haycock, Philip C, Relton, Caroline L, Martin, Richard M, Smith, George Davey, Kraft, Peter, Gao, Chi, Tworoger, Shelley, Le Marchand, Loïc, Wilkens, Lynne R, Park, Sungshim L, Haiman, Christopher, Field, John K, Davies, Michael, Marcus, Michael, Liu, Geoffrey, Caporaso, Neil E, Christiani, David C, Wei, Yongyue, Chen, Chu, Doherty, Jennifer A, Severi, Gianluca, Goodman, Gary E, Hung, Rayjean J, Amos, Christopher I, McKay, James, Johansson, Mattias, and Brennan, Paul

Subjects
Humans, Lung Neoplasms, Body Mass Index, Risk Factors, Case-Control Studies, Smoking, Female, Male, Mendelian Randomization Analysis
Abstract

Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse causality. We used the two-sample Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiology by constructing a genetic instrument for BMI, based on results from the GIANT consortium, which was evaluated in relation to lung cancer risk using GWAS results on 16,572 lung cancer cases and 21,480 controls. Results were stratified by histological subtype, smoking status and sex. An increase of one standard deviation (SD) in BMI (4.65 Kg/m(2)) raised the risk for lung cancer overall (OR = 1.13; P = 0.10). This was driven by associations with squamous cell (SQ) carcinoma (OR = 1.45; P = 1.2 × 10(-3)) and small cell (SC) carcinoma (OR = 1.81; P = 0.01). An inverse trend was seen for adenocarcinoma (AD) (OR = 0.82; P = 0.06). In stratified analyses, a 1 SD increase in BMI was inversely associated with overall lung cancer in never smokers (OR = 0.50; P = 0.02). These results indicate that higher BMI may increase the risk of certain types of lung cancer, in particular SQ and SC carcinoma.

Published
2016

7. Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population

Author

Carrat, Fabrice, Saba Villarroel, Paola Mariela, Lapidus, Nathanaël, Fourié, Toscane, Blanché, Hélène, Dorival, Céline, Nicol, Jérôme, Deleuze, Jean-François, Robineau, Olivier, Touvier, Mathilde, Severi, Gianluca, Zins, Marie, de Lamballerie, Xavier, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Etude du Polymorphisme Humain (CEPH), Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Fondation Jean Dausset-Université Paris Cité (UPCité), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), Université Paris Cité (UPCité), This study ANR (Agence Nationale de la Recherche, #ANR-20-COVI-000, #ANR-10-COHO-06), Fondation pour la Recherche Médicale (#20RR052-00), Inserm (Institut National de la Santé et de la Recherche Médicale, #C20-26). The sponsor and funders facilitated data acquisition but did not participate in the study design, analysis, interpretation or drafting. Cohorts funding The CONSTANCES Cohort Study is supported by the Caisse Nationale d’Assurance Maladie (CNAM), the French Ministry of Health, the Ministry of Research, the Institut national de la santé et de la recherche médicale. CONSTANCES benefits from a grant from the French National Research Agency [Grant Number ANR-11-INBS-0002] and is also partly funded by MSD, AstraZeneca, Lundbeck and L’Oreal. The E3N-E4N cohort is supported by the following institutions: Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation, INSERM, University Paris-Saclay, Gustave Roussy, the MGEN, and the French League Against Cancer. The NutriNet-Santé study is supported by the following public institutions: Ministère de la Santé, Santé Publique France, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRAE), Conservatoire National des Arts et Métiers (CNAM) and Sorbonne Paris Nord. The CEPH-Biobank is supported by the «Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation»., SAPRIS-SERO Study Group: Fabrice Carrat, Marie Zins, Gianluca Severi, Mathilde Touvier, Hélène Blanché, Jean-François Deleuze, Xavier de Lamballerie, Clovis Lusivika-Nzinga, Gregory Pannetier, Nathanael Lapidus, Isabelle Goderel, Céline Dorival, Jérôme Nicol, Olivier Robineau, Sofiane Kab, Adeline Renuy, Stéphane Le-Got, Céline Ribet, Mireille Pellicer, Emmanuel Wiernik, Marcel Goldberg, Fanny Artaud, Pascale Gerbouin-Rérolle, Mélody Enguix, Camille Laplanche, Roselyn Gomes-Rima, Lyan Hoang, Emmanuelle Correia, Alpha Amadou Barry, Nadège Senina, Julien Allegre, Fabien Szabo de Edelenyi, Nathalie Druesne-Pecollo, Younes Esseddik, Serge Hercberg, Mélanie Deschasaux, Hélène Blanché, Jean-Marc Sébaoun, Jean-Christophe Beaudoin, Laetitia Gressin, Valérie Morel, Ouissam Ouili, Jean-François Deleuze, Laetitia Ninove, Stéphane Priet, Paola Mariela Saba Villarroel, Toscane Fourié, Souand Mohamed Ali, Abdenour Amroun, Morgan Seston, Nazli Ayhan, Boris Pastorino, ANR-20-COVI-0038,COVID-METAFLAM,Mise en place d'une approche metabolomique ciblée à réponse rapide pour modéliser les cinétiques d'évolution des médiateurs de l'inflammation chez les patients COVID-19 au cours de leur prise en charge dans les services de réanimations.(2020), Université Paris Cité - UFR Médecine [Santé] (UPCité UFR Médecine), and Demarquay, Sandrine

Subjects
Adult, [SDV] Life Sciences [q-bio], COVID-19 Vaccines, Multidisciplinary, SARS-CoV-2, [SDV]Life Sciences [q-bio], Antibody Formation, Vaccination, COVID-19, Humans, Antibodies, Viral
Abstract

Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 between April and October 2020 and followed-up with serological testing between May and October 2021. Eight follow-up profiles were defined depending on SARS-CoV-2 infection (0, 1 or 2) and COVID-19 vaccination (0, 1, 2 or 3). The anti-spike titer was lower in adults with no vaccination even in case of infection or reinfection, while it was higher in adults with infection followed by vaccination. The anti-spike titer was negatively correlated with age in vaccinated but uninfected adults, whereas it was positively correlated with age in unvaccinated but infected adults. In adults with 2 vaccine injections and no infection, the vaccine protocol, age, gender, and time since the last vaccine injection were independently associated with the anti-spike titer. The decrease in anti-spike titer was much more rapid in vaccinated than in infected subjects. These results highlight the strong heterogeneity of the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination.

Published
2022

8. Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

Author

Fiorito, Giovanni, primary, Polidoro, Silvia, additional, Dugué, Pierre-Antoine, additional, Kivimaki, Mika, additional, Ponzi, Erica, additional, Matullo, Giuseppe, additional, Guarrera, Simonetta, additional, Assumma, Manuela B., additional, Georgiadis, Panagiotis, additional, Kyrtopoulos, Soterios A., additional, Krogh, Vittorio, additional, Palli, Domenico, additional, Panico, Salvatore, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Chadeau-Hyam, Marc, additional, Stringhini, Silvia, additional, Severi, Gianluca, additional, Hodge, Allison M., additional, Giles, Graham G., additional, Marioni, Riccardo, additional, Karlsson Linnér, Richard, additional, O’Halloran, Aisling M., additional, Kenny, Rose A., additional, Layte, Richard, additional, Baglietto, Laura, additional, Robinson, Oliver, additional, McCrory, Cathal, additional, Milne, Roger L., additional, and Vineis, Paolo, additional

Published
2017
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9. Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation

Author

Panagiotis Georgiadis, Vittorio Krogh, Silvia Stringhini, Giuseppe Matullo, Allison M. Hodge, Gianluca Severi, Silvia Polidoro, Riccardo E. Marioni, Mika Kivimäki, Domenico Palli, Pierre Antoine Dugué, Oliver Robinson, Giovanni Fiorito, Soterios A. Kyrtopoulos, Simonetta Guarrera, Richard Layte, Laura Baglietto, Marc Chadeau-Hyam, Roger L. Milne, Aisling M O'Halloran, Manuela Bianca Assumma, Carlotta Sacerdote, Richard Karlsson Linnér, Rose Anne Kenny, Erica Ponzi, Salvatore Panico, Paolo Vineis, Cathal McCrory, Rosario Tumino, Graham G. Giles, Fiorito, Giovanni, Polidoro, Silvia, Dugué, Pierre-Antoine, Kivimaki, Mika, Ponzi, Erica, Matullo, Giuseppe, Guarrera, Simonetta, Assumma, Manuela B., Georgiadis, Panagioti, Kyrtopoulos, Soterios A., Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Chadeau-Hyam, Marc, Stringhini, Silvia, Severi, Gianluca, Hodge, Allison M., Giles, Graham G., Marioni, Riccardo, Karlsson Linnér, Richard, O'Halloran, Aisling M., Kenny, Rose A., Layte, Richard, Baglietto, Laura, Robinson, Oliver, Mccrory, Cathal, Milne, Roger L., Vineis, Paolo, Economics, Amsterdam Neuroscience - Complex Trait Genetics, and Medical Research Council (MRC)

Subjects
0301 basic medicine, Male, Aging, lcsh:Medicine, Epigenesis, Genetic, Cohort Studies, 0302 clinical medicine, Aging/genetics, Medicine, 030212 general & internal medicine, Early childhood, POSITION, lcsh:Science, WEAR-AND-TEAR, media_common, Genetics, Multidisciplinary, CHILDHOOD EXPERIENCES, Longevity, Middle Aged, Allostatic load, 3. Good health, Multidisciplinary Sciences, Science & Technology - Other Topics, population characteristics, Female, Cohort study, DNA Methylation/genetics, media_common.quotation_subject, Article, 03 medical and health sciences, INFLAMMATION, Humans, Epigenetics, MIDLIFE FINDINGS, ALLOSTATIC LOAD, Socioeconomic status, METAANALYSIS, Aged, Genetic/genetics, Science & Technology, business.industry, lcsh:R, Epigenesis, Genetic/genetics, Socioeconomic Factors, Social environment, DISEASE RISK, social sciences, DNA Methylation, 030104 developmental biology, Ageing, lcsh:Q, ADULT HEALTH, BRITISH BIRTH COHORT, business, Demography, Epigenesis
Abstract

Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We investigated the association of SES with AA in more than 5,000 individuals belonging to three independent prospective cohorts from Italy, Australia, and Ireland. Low SES was associated with greater AA (β = 0.99 years; 95% CI 0.39,1.59; p = 0.002; comparing extreme categories). The results were consistent across different SES indicators. The associations were only partially modulated by the unhealthy lifestyle habits of individuals with lower SES. Individuals who experienced life-course SES improvement had intermediate AA compared to extreme SES categories, suggesting reversibility of the effect and supporting the relative importance of the early childhood social environment. Socioeconomic adversity is associated with accelerated epigenetic aging, implicating biomolecular mechanisms that may link SES to age-related diseases and longevity.

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