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Your search keyword '"Rosilene M. Elias"' showing total 3 results
Start Over Author "Rosilene M. Elias" Journal scientific reports
3 results on '"Rosilene M. Elias"'

1. A randomized clinical trial to evaluate the effects of icodextrin on left ventricular mass index in peritoneal dialysis

Author

Lilian Cordeiro, Walther Yoshiharu Ishikawa, Maria Claudia C. Andreoli, Maria Eugenia F. Canziani, Luiza Karla R. P. Araujo, Benedito J. Pereira, Hugo Abensur, Rosa M. A. Moysés, and Rosilene M. Elias

Subjects
Medicine, Science
Abstract

Abstract Left ventricular hypertrophy is a risk factor for cardiovascular mortality in patients on peritoneal dialysis (PD). Because icodextrin has a greater ultrafiltration power compared with glucose-based solutions for long dwell, it could improve left ventricular mass by reducing fluid overload. This was a randomized clinical trial that included patients on PD recruited from 2 teaching hospitals, in Sao Paulo—Brazil. Patients were allocated to the control glucose group (GLU) or the intervention icodextrin (ICO) group. Clinical and cardiac magnetic resonance image (MRI) parameters were evaluated at baseline and 6 months after randomization. The primary outcome was the change in left ventricular mass adjusted by surface area (ΔLVMI), measured by cardiac MRI. A total of 22 patients completed the study (GLU, N = 12 and ICO, N = 10). Baseline characteristics such as age, sex, underlying disease, and time on dialysis were similar in both groups. At baseline, 17 patients (77.3%) presented with left ventricular hypertrophy with no difference between groups (p = 0.748). According to the total body water (TBW)/extracellular water (ECW) ratio, 36.8% and 80% of patients from GLU and ICO groups, respectively, were considered hypervolemic (p = 0.044). During follow-up, ΔLVMI was 3.9 g/m (− 10.7, 2.2) in GLU and 5.2 (− 26.8, 16.8) in ICO group (p = 0.651). ΔLVMI correlated with change in brain natriuretic peptide (r = 0.566, p = 0.044), which remained significant in a multiple regression analysis. The use of the icodextrin-based solution in prevalent patients on PD compared with a glucose-based solution was not able to improve LMV. A larger randomized trial with a longer follow-up period may be needed to show changes in LVM in this patient population. Trial registration: this study has been registered at ReBEC (Registro Brasileiro de Ensaios Clinicos) under the identification #RBR-2mzhmj2, available at: https://ensaiosclinicos.gov.br/pesquisador .

Published
2022
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2. High Dialysate Calcium Concentration is Associated with Worsening Left Ventricular Function

Author

Luciano F. Drager, Rosa M.A. Moysés, T. A. Macedo, T. M. S. Braga, Wagner V. Dominguez, Fabiana G. Graciolli, Bosco Christiano Maciel da Silva, Vitor B. Silva, and Rosilene M. Elias

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, lcsh:Medicine, chemistry.chemical_element, Hemodynamics, Blood Pressure, Calcium, Dialysate calcium, Ventricular Function, Left, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, lcsh:Science, chemistry.chemical_classification, Myocardial stunning, Cross-Over Studies, Multidisciplinary, Ventricular function, lcsh:R, Middle Aged, medicine.disease, Crossover study, Hemodialysis Solutions, 030104 developmental biology, Blood pressure, Endocrinology, chemistry, Echocardiography, Transferrin, lcsh:Q, Female, Dialysis, 030217 neurology & neurosurgery
Abstract

Dialysate calcium concentration (d[Ca]) might have a cardiovascular impact in patients on haemodialysis (HD) since a higher d[Ca] determines better hemodynamic tolerability. We have assessed the influence of d[Ca] on global longitudinal strain (GLS) by two-dimensional echocardiography using speckle-tracking imaging before and in the last hour of HD. This is an observational crossover study using d[Ca] 1.75 mmol/L and 1.25 mmol/L. Ultrafiltration was the same between interventions; patients aged 44 ± 13 years (N = 19). The 1.75 mmol/L d[Ca] was associated with lighter drop of blood pressure. Post HD serum total calcium was higher with d[Ca] 1.75 than with 1.25 mmol/L (11.5 ± 0.8 vs. 9.1 ± 0.5 mg/dL, respectively, p

Published
2019
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3. 25-vitamin D reduces inflammation in uremic environment

Author

Rosa M.A. Moysés, Armando Morales, Caren Cristina Grabulosa, Rosilene M. Elias, Walter Pereira Pinto, Maria Aparecida Dalboni, Rodrigo Barbosa de Oliveira Brito, and Jacqueline Ferritto Rebello

Subjects
0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Anti-Inflammatory Agents, lcsh:Medicine, Inflammation, 030204 cardiovascular system & hematology, medicine.disease_cause, Calcitriol receptor, Article, Cathelicidin, 03 medical and health sciences, 0302 clinical medicine, Immune system, Applied immunology, Cathelicidins, Internal medicine, medicine, Vitamin D and neurology, Humans, Vitamin D, Receptor, lcsh:Science, Chemokine CCL2, Uremia, Multidisciplinary, business.industry, Interleukin-6, Tumor Necrosis Factor-alpha, lcsh:R, NF-kappa B, Interleukin-10, Haemodialysis, 030104 developmental biology, Endocrinology, TLR4, lcsh:Q, medicine.symptom, business, Reactive Oxygen Species, Oxidative stress, Antimicrobial Cationic Peptides
Abstract

Chronic kidney disease (CKD) is characterized by loss of renal function and a consequent increase of serum uremic toxins, which contribute to inflammation status. Deficiency of 25-vitamin D, often found in patients with CKD, has been included as an inflammatory factor since it might modulate the immune system. The aim of this study was to investigate the role of 25-vitamin D on inflammatory pathways in healthy and uremic environment. Toll-like receptor 4 (TLR4), oxidative stress (ROS), vitamin D receptor (VDR), 1-α hydroxylase (CYP27), 24 hydroxylase, cathelicidin, and MCP-1 were evaluated in monocytes exposed to a uremic serum pool compared with healthy pool. The human monocytes lineage (U937) was incubated with or without 25-vitamin D (50 ng/ml for 24 hours). TRL4, VDR, CYP27, CYP24, and ROS were evaluated by flow cytometry. We used ELISA to measure IL-6, TNF-α, IL-10, cathelicidin, and MCP-1 in the cell culture supernatant. We observed a higher expression of TRL-4, IL-6, TNF-α, IL-10, cathelicidin and MCP-1 in monocytes incubated with uremic serum when compared with serum from healthy individuals. Supplementation of 25-vitamin D was able to reduce the expression of TRL4, cathelicidin, and MCP-1 in the uremic environment. There was no difference in the expression of VDR, CYP27 and CYP24 intracellular enzymes. This in vitro study showed that the uremic pool activates inflammatory response in monocytes, which was reversed by 25-vitamin D supplementation; this finding suggests that 25-vitamin D has an anti-inflammatory role in the uremic environment.

Published
2019

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