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Your search keyword '"Rakugi, Hiromi"' showing total 19 results
Start Over Author "Rakugi, Hiromi" Journal scientific reports
19 results on '"Rakugi, Hiromi"'

1. Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction

Author

Hayashi, Hiroki, Sun, Jiao, Yanagida, Yuka, Otera, Takako, Tai, Jiayu A., Nishikawa, Tomoyuki, Yamashita, Kunihiko, Sakaguchi, Naoki, Yoshida, Shota, Baba, Satoshi, Chang, Chin Yang, Shimamura, Munehisa, Okamoto, Sachiko, Amaishi, Yasunori, Chono, Hideto, Mineno, Junichi, Rakugi, Hiromi, Morishita, Ryuichi, and Nakagami, Hironori

Published
2023
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3. Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant

Author

Hayashi, Hiroki, Sun, Jiao, Yanagida, Yuka, Otera, Takako, Sasai, Miwa, Chang, Chin Yang, Tai, Jiayu A., Nishikawa, Tomoyuki, Yamashita, Kunihiko, Sakaguchi, Naoki, Yoshida, Shota, Baba, Satoshi, Shimamura, Munehisa, Okamoto, Sachiko, Amaishi, Yasunori, Chono, Hideto, Mineno, Junichi, Rakugi, Hiromi, Morishita, Ryuichi, Yamamoto, Masahiro, and Nakagami, Hironori

Published
2022
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5. Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study

Author

Miki, Koji, Kitamura, Masahiro, Hatta, Kodai, Kamide, Kei, Gondo, Yasuyuki, Yamashita, Motozo, Takedachi, Masahide, Nozaki, Takenori, Fujihara, Chiharu, Kashiwagi, Yoichiro, Iwayama, Tomoaki, Takahashi, Toshihito, Sato, Hitomi, Murotani, Yuki, Kabayama, Mai, Takeya, Yasushi, Takami, Yoichi, Akasaka, Hiroshi, Yamamoto, Koichi, Sugimoto, Ken, Ishizaki, Tatsuro, Masui, Yukie, Rakugi, Hiromi, Ikebe, Kazunori, and Murakami, Shinya

Published
2021
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8. Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism.

Author

Nakamaru, Ryo, Yamamoto, Koichi, Akasaka, Hiroshi, Rakugi, Hiromi, Kurihara, Isao, Yoneda, Takashi, Ichijo, Takamasa, Katabami, Takuyuki, Tsuiki, Mika, Wada, Norio, Yamada, Tetsuya, Kobayashi, Hiroki, Tamura, Kouichi, Ogawa, Yoshihiro, Kawashima, Junji, Inagaki, Nobuya, Fujita, Megumi, Watanabe, Minemori, Kamemura, Kohei, and Okamura, Shintaro

Subjects
HYPERALDOSTERONISM, ADRENALECTOMY, AGE factors in disease, MINERALOCORTICOID receptors, GLOMERULAR filtration rate
Abstract

Although adrenalectomy (ADX) is an established treatment for unilateral primary aldosteronism (uPA), the influence of age on the surgical outcomes is poorly understood. Therefore, we aimed to elucidate how age affects the clinical outcomes after treatments. We analyzed 153 older (≥ 65 years) and 702 younger patients (< 65 years) with uPA, treated either with ADX or mineralocorticoid receptor antagonist (MRA) in the Japan PA Study, and compared the estimated glomerular filtration rate (eGFR) or blood pressure over a 36-month period after treatments. ADX-treated patients showed severer biochemical indicators than MRA-treated patients. During 6 and 36 months, the eGFR decreased more prominently in older but not in younger patients with ADX than in those with MRA, which remained significant after adjustment with the inverse probability of treatment weighting (IPTW). There was a significant interaction between the age-groups and the treatment choices in the change of the eGFR with IPTW-adjusted analysis. The post-treatment dose of antihypertensive medication was lower in younger and higher in older patients with ADX than those with MRA. The clinical benefit of ADX differed between younger and older patients with uPA. These findings indicate the need for further validation on whether ADX can benefit older patients with uPA. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

Author

Jin, Yingji, primary, Takeda, Yoshito, additional, Kondo, Yasushi, additional, Tripathi, Lokesh P., additional, Kang, Sujin, additional, Takeshita, Hikari, additional, Kuhara, Hanako, additional, Maeda, Yohei, additional, Higashiguchi, Masayoshi, additional, Miyake, Kotaro, additional, Morimura, Osamu, additional, Koba, Taro, additional, Hayama, Yoshitomo, additional, Koyama, Shohei, additional, Nakanishi, Kaori, additional, Iwasaki, Takeo, additional, Tetsumoto, Satoshi, additional, Tsujino, Kazuyuki, additional, Kuroyama, Muneyoshi, additional, Iwahori, Kota, additional, Hirata, Haruhiko, additional, Takimoto, Takayuki, additional, Suzuki, Mayumi, additional, Nagatomo, Izumi, additional, Sugimoto, Ken, additional, Fujii, Yuta, additional, Kida, Hiroshi, additional, Mizuguchi, Kenji, additional, Ito, Mari, additional, Kijima, Takashi, additional, Rakugi, Hiromi, additional, Mekada, Eisuke, additional, Tachibana, Isao, additional, and Kumanogoh, Atsushi, additional

Published
2018
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11. Mapping the genetic diversity of HLA haplotypes in the Japanese populations

Author

Saw, Woei Yuh, Liu, Xuanyao, Khor, Chiea Chuen, Takeuchi, Fumihiko, Katsuya, Tomohiro, Kimura, Ryosuke, Nabika, Toru, Ohkubo, Takayoshi, Tabara, Yasuharu, Yamamoto, Ken, Yokota, Mitsuhiro, Akiyama, Koichi, Asano, Hiroyuki, Asayama, Kei, Haga, Toshikazu, Hara, Azusa, Hirose, Takuo, Hosaka, Miki, Ichihara, Sahoko, Imai, Yutaka, Inoue, Ryusuke, Ishiguro, Aya, Isomura, Minoru, Isono, Masato, Kamide, Kei, Kato, Norihiro, Kikuya, Masahiro, Kohara, Katsuhiko, Matsubara, Tatsuaki, Matsuda, Ayako, Metoki, Hirohito, Miki, Tetsuro, Murakami, Keiko, Nakatochi, Masahiro, Ogihara, Toshio, Ohnaka, Keizo, Rakugi, Hiromi, Satoh, Michihiro, Shiwaku, Kunihiro, Sugimoto, Ken, Takami, Yoichi, Takayanagi, Ryoichi, Tsubota-Utsugi, Megumi, Yamamoto, Koichi, Yamasaki, Masayuki, Yasui, Daisaku, and Teo, Yik Ying

Abstract

Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and the mainland prefectures. The Major Histocompatibility Complex (MHC) region has consistently emerged as the most polymorphic region in the human genome, harbouring numerous biologically important variants; nevertheless the presence of population-specific long haplotypes hinders the imputation of SNPs and classical HLA alleles. Here, we examined the extent of genetic variation at the MHC between eight Japanese populations sampled from Okinawa, and six other prefectures located in or close to the mainland of Japan, specifically focusing at the haplotypes observed within each population, and what the impact of any variation has on imputation. Our results indicated that Okinawa was genetically farther to the mainland Japanese than were Gujarati Indians from Tamil Indians, while the mainland Japanese from six prefectures were more homogeneous than between northern and southern Han Chinese. The distribution of haplotypes across Japan was similar, although imputation was most accurate for Okinawa and several mainland prefectures when population-specific panels were used as reference.

Published
2015

12. Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence

Author

Kaimori, Jun-Ya, primary, Isaka, Yoshitaka, additional, Hatanaka, Masaki, additional, Yamamoto, Satoko, additional, Ichimaru, Naotsugu, additional, Fujikawa, Akihiko, additional, Shibata, Hiroshi, additional, Fujimori, Akira, additional, Miyoshi, Sosuke, additional, Yokawa, Takashi, additional, Kuroda, Kagayaki, additional, Moriyama, Toshiki, additional, Rakugi, Hiromi, additional, and Takahara, Shiro, additional

Published
2017
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14. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

Author

Takeshita, Hikari, primary, Yamamoto, Koichi, additional, Nozato, Satoko, additional, Inagaki, Tadakatsu, additional, Tsuchimochi, Hirotsugu, additional, Shirai, Mikiyasu, additional, Yamamoto, Ryohei, additional, Imaizumi, Yuki, additional, Hongyo, Kazuhiro, additional, Yokoyama, Serina, additional, Takeda, Masao, additional, Oguro, Ryosuke, additional, Takami, Yoichi, additional, Itoh, Norihisa, additional, Takeya, Yasushi, additional, Sugimoto, Ken, additional, Fukada, So-ichiro, additional, and Rakugi, Hiromi, additional

Published
2017
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