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21 results on '"Patil, A. R"'

9. Study of Kyasanur forest disease viremia, antibody kinetics, and virus infection in target organs of Macaca radiata

Author

Patil, Dilip R., Yadav, Pragya D., Shete, Anita, Chaubal, Gouri, Mohandas, Sreelekshmy, Sahay, Rima R., Jain, Rajlaxmi, Mote, Chandrashekhar, Kumar, Sandeep, Kaushal, Himanshu, Kore, Pravin, Patil, Savita, Majumdar, Triparna, Fulari, Siddharam, Suryawanshi, Annasaheb, Kadam, Manoj, Pardeshi, Prachi G., Lakra, Rajen, Sarkale, Prasad, and Mourya, Devendra T.

Published
2020
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15. Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS- mediated neuropathic pain in rats

Author

Magar, Shital, Nayak, Deepika, Mahajan, Umesh B., Patil, Kalpesh R., Shinde, Sachin D., Goyal, Sameer N., Swaminarayan, Shivang, Patil, Chandragouda R., Ojha, Shreesh, and Kundu, Chanakya Nath

Subjects
fluids and secretions, bacteria, Article
Abstract

Despite the availability of multiple therapeutic agents, the search for novel pain management of neuropathic pain is still a challenge. Oxidative stress and inflammatory signaling are prominently involved in clinical manifestation of neuropathic pain. Toxicodendron pubescens, popularly known as Rhus Tox (RT) is recommended in alternative medicines as an anti-inflammatory and analgesic remedy. Earlier, we reported anti-inflammatory, anti-arthritic and immunomodulatory activities of Rhus Tox. In continuation, we evaluated antinociceptive efficacy of Rhus Tox in the neuropathic pain and delineated its underlying mechanism. Initially, in-vitro assay using LPS-mediated ROS-induced U-87 glioblastoma cells was performed to study the effect of Rhus Tox on reactive oxygen species (ROS), anti-oxidant status and cytokine profile. Rhus Tox decreased oxidative stress and cytokine release with restoration of anti-oxidant systems. Chronic treatment with Rhus Tox ultra dilutions for 14 days ameliorated neuropathic pain revealed as inhibition of cold, warm and mechanical allodynia along with improved motor nerve conduction velocity (MNCV) in constricted nerve. Rhus Tox decreased the oxidative and nitrosative stress by reducing malondialdehyde (MDA) and nitric oxide (NO) content, respectively along with up regulated glutathione (GSH), superoxide dismutase (SOD) and catalase activity in sciatic nerve of rats. Notably, Rhus Tox treatment caused significant reductions in the levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) as compared with CCI-control group. Protective effect of Rhus Tox against CCI-induced sciatic nerve injury in histopathology study was exhibited through maintenance of normal nerve architecture and inhibition of inflammatory changes. Overall, neuroprotective effect of Rhus Tox in CCI-induced neuropathic pain suggests the involvement of anti-oxidative and anti-inflammatory mechanisms.

Published
2018

21. Comprehensive verbal fluency features predict executive function performance

Author

Amunts, Julia, Camilleri, Julia A., Eickhoff, Simon B., Patil, Kaustubh R., Heim, Stefan, von Polier, Georg G., and Weis, Susanne

Subjects
Adult, Male, Verbal Behavior, Science, Middle Aged, Healthy Volunteers, Article, Semantics, Machine Learning, Executive Function, Young Adult, Human behaviour, Medicine, Humans, Female, ddc:600, Language
Abstract

Scientific reports 11(1), 6929 (2021). doi:10.1038/s41598-021-85981-1, Published by Macmillan Publishers Limited, part of Springer Nature, [London]

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