1. Melanopsin photoreception contributes to human visual detection, temporal and colour processing.
- Author
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Zele AJ, Feigl B, Adhikari P, Maynard ML, and Cao D
- Subjects
- Adult, Color, Female, Humans, Light, Male, Photic Stimulation methods, Photoreceptor Cells physiology, Retina physiology, Retinal Cone Photoreceptor Cells physiology, Retinal Ganglion Cells physiology, Retinal Rod Photoreceptor Cells physiology, Rod Opsins metabolism, Color Vision physiology, Rod Opsins physiology, Vision, Ocular physiology
- Abstract
The visual consequences of melanopsin photoreception in humans are not well understood. Here we studied melanopsin photoreception using a technique of photoreceptor silent substitution with five calibrated spectral lights after minimising the effects of individual differences in optical pre-receptoral filtering and desensitising penumbral cones in the shadow of retinal blood vessels. We demonstrate that putative melanopsin-mediated image-forming vision corresponds to an opponent S-OFF L + M-ON response property, with an average temporal resolution up to approximately 5 Hz, and >10x higher thresholds than red-green colour vision. With a capacity for signalling colour and integrating slowly changing lights, melanopsin-expressing intrinsically photosensitive retinal ganglion cells maybe the fifth photoreceptor type for peripheral vision.
- Published
- 2018
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