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1,179 results on '"Marina P."'

1. Features of the response to subchronic low-dose exposure to copper oxide nanoparticles in rats

Author

Marina P. Sutunkova, Yuliya V. Ryabova, Ilzira A. Minigalieva, Tatiana V. Bushueva, Renata R. Sakhautdinova, Ivan A. Bereza, Daria R. Shaikhova, Anna M. Amromina, Aleksei I. Chemezov, Ivan G. Shelomencev, Lev A. Amromin, Irene E. Valamina, and Liubov V. Toropova

Subjects
Medicine, Science
Abstract

Abstract Copper is an essential trace element for human health and, at the same time, a major industrial metal widely used both in its elemental form and in compounds. We conducted a dose-dependent assessment of the response of outbred albino male rats to subchronic low-dose exposure to copper oxide nanoparticles administered intraperitoneally at cumulative doses of 18 and 36 mg/kg during 6 weeks to exposure groups 1 and 2, respectively. We observed disorders at different levels of organization of the body in the exposed animals, from molecular to organismal. The observed decrease in the activity of succinate dehydrogenase in nucleated blood cells gave evidence of impaired bioenergetics processes. In view of the results of the metabolomics analysis, we assume mitochondrial damage and contribution of apoptotic processes to the pathology induced by copper poisoning. We also assume neurodegenerative effects based on the assessed morphological parameters of the nervous system, results of behavioral tests, and a decreased level of expression of genes encoding NMDA receptor subunits in the hippocampus. The hepatotoxic effect noted by a number of metabolomics-based, biochemical, and cytological indicators was manifested by the impaired protein-synthesizing function of the liver and enhanced degenerative processes in its cells. We also observed a nephrotoxic effect of nanosized copper oxide with a predominant lesion of proximal kidney tubules. At the same time, both doses tested demonstrated such positive health effects as a statistically significant decrease in the activity of alkaline phosphatase and the nucleated blood cell DNA fragmentation factor. Judging by the changes observed, the cumulative dose of copper oxide nanoparticles of 18 mg/kg body weight administered intraperitoneally approximates the threshold one for rats. The established markers of health impairments may serve as a starting point in the development of techniques of early diagnosis of copper poisoning.

Published
2023
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2. Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats

Author

Marina P. Sutunkova, Ilzira A. Minigalieva, Ivan G. Shelomencev, Larisa I. Privalova, Yuliya V. Ryabova, Anastasiya V. Tazhigulova, Lev A. Amromin, Regina F. Minigalieva, Yuliya M. Sutunkova, Vladimir B. Gurvich, Eugenya V. Makoveeva, and Liubov V. Toropova

Subjects
Medicine, Science
Abstract

Abstract White outbred female rats were exposed intranasally to 50-µL of suspension of lead oxide nanoparticles (PbO NPs) at a concentration of 0.5 mg/mL thrice a week during six weeks. A control group of rats was administered deionized water in similar volumes and conditions. The developed intoxication was manifested by altered biochemical and cytochemical parameters, as well as behavioral reactions of animals. Using electron microscopy and energy-dispersive X-ray spectroscopy techniques, we revealed deposition of PbO NPs in the olfactory bulb, but not in basal ganglia, and an increase in the number of axons with damage to the myelin sheath in the tissues of olfactory bulb and basal ganglia, changes in the ultrastructure of mitochondria of neurons in the tissues of olfactory bulb and basal ganglia of the brain, and differences in the mitochondrial profile of neurons in different regions of the rat brain. Our results collectively suggest that the central nervous system may be a target of low-level toxicity of lead oxide nanoparticles.

Published
2022
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3. Embryotoxic activity of 3C protease of human hepatitis A virus in developing Danio rerio embryos

Author

Polina I. Selina, Maria A. Karaseva, Alexey A. Komissarov, Dina R. Safina, Nataliya A. Lunina, Marina P. Roschina, Eugene D. Sverdlov, Ilya V. Demidyuk, and Sergey V. Kostrov

Subjects
Medicine, Science
Abstract

Abstract The 3C protease is a key factor in picornavirus-induced pathologies with a comprehensive action on cell targets. However, the effects induced by the enzyme have not been described at the organismic level. Here, the model of developing Danio rerio embryos was used to analyze possible toxic effects of the 3C protease of human hepatitis A virus (3Cpro) at the whole-body level. The transient 3Cpro expression had a notable lethal effect and induced a number of specific abnormalities in Danio rerio embryos within 24 h. These effects are due to the proteolytic activity of the enzyme. At the same time, the 3Cpro variant with reduced catalytic activity (3Cmut) increased the incidence of embryonic abnormalities; however, this effect was smaller compared to the native enzyme form. While the expression of 3Cmut increased the overall rate of abnormalities, no predominance of specific ones was observed. The data obtained point to a presence significant impact of picornavirus 3Cprotease at the whole-organism level and make contribution to the study of the infectious process caused by human hepatitis A virus.

Published
2021
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4. Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Author

Elrick, Hillary, Peterson, Kevin A, Willis, Brandon J, Lanza, Denise G, Acar, Elif F, Ryder, Edward J, Teboul, Lydia, Kasparek, Petr, Birling, Marie-Christine, Adams, David J, Bradley, Allan, Braun, Robert E, Brown, Steve D, Caulder, Adam, Codner, Gemma F, DeMayo, Francesco J, Dickinson, Mary E, Doe, Brendan, Duddy, Graham, Gertsenstein, Marina, Goodwin, Leslie O, Hérault, Yann, Lintott, Lauri G, Lloyd, KC Kent, Lorenzo, Isabel, Mackenzie, Matthew, Mallon, Ann-Marie, McKerlie, Colin, Parkinson, Helen, Ramirez-Solis, Ramiro, Seavitt, John R, Sedlacek, Radislav, Skarnes, William C, Smedley, Damien, Wells, Sara, White, Jacqueline K, Wood, Joshua A, Murray, Stephen A, Heaney, Jason D, and Nutter, Lauryl MJ

Subjects
Biological Sciences, Genetics, Biotechnology, 1.1 Normal biological development and functioning, Animals, Genes, Essential, Mice, Gene Editing, Mice, Knockout, CRISPR-Cas Systems, Alleles, Mice, Inbred C57BL, Male, Female, Genetic Engineering, Phenotype, International Mouse Phenotyping Consortium, Cas9, Genome editing, Knockout, Mouse
Abstract

The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for its increased capacity and flexibility to efficiently generate null alleles in the C57BL/6N strain. In addition to being a valuable novel and accessible research resource, the production of 3313 knockout mouse lines using comparable protocols provides a rich dataset to analyze experimental and biological variables affecting in vivo gene engineering with Cas9. Mouse line production has two critical steps - generation of founders with the desired allele and germline transmission (GLT) of that allele from founders to offspring. A systematic evaluation of the variables impacting success rates identified gene essentiality as the primary factor influencing successful production of null alleles. Collectively, our findings provide best practice recommendations for using Cas9 to generate alleles in mouse essential genes, many of which are orthologs of genes linked to human disease.

Published
2024

5. Singly-excited resonant open quantum system Tavis-Cummings model with quantum circuit mapping.

Author

Marinkovic, Marina and Radulaski, Marina

Abstract

Tavis-Cummings (TC) cavity quantum electrodynamical effects, describing the interaction of N atoms with an optical resonator, are at the core of atomic, optical and solid state physics. The full numerical simulation of TC dynamics scales exponentially with the number of atoms. By restricting the open quantum system to a single excitation, typical of experimental realizations in quantum optics, we analytically solve the TC model with an arbitrary number of atoms with linear complexity. This solution allows us to devise the Quantum Mapping Algorithm of Resonator Interaction with N Atoms (Q-MARINA), an intuitive TC mapping to a quantum circuit with linear space and time scaling, whose N+1 qubits represent atoms and a lossy cavity, while the dynamics is encoded through 2N entangling gates. Finally, we benchmark the robustness of the algorithm on a quantum simulator and superconducting quantum processors against the quantum master equation solution on a classical computer.

Published
2023

6. Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics

Author

Patysheva, Marina R., Kolegova, Elena S., Khozyainova, Anna A., Prostakishina, Elizaveta A., Korobeynikov, Vyacheslav Y., Menyailo, Maxim E., Iamshchikov, Pavel S., Loos, Dmitry M., Kovalev, Oleg I., Zavyalova, Marina V., Fedorova, Irina K., Kulbakin, Denis E., Larionova, Irina V., Polyakov, Andrey P., Yakovleva, Liliya P., Kropotov, Mikhail A., Sukortseva, Natalya S., Lu, Yusheng, Jia, Lee, Arora, Rohit, Choinzonov, Evgeny L., Bose, Pinaki, and Denisov, Evgeny V.

Published
2024
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8. Global validation of data-assimilative electron ring current nowcast for space weather applications.

Author

Haas, Bernhard, Wutzig, Michael, Szabó-Roberts, Mátyás, García Peñaranda, Marina, Castillo Tibocha, Angelica, Himmelsbach, Julia, Wang, Dedong, Miyoshi, Yoshizumi, Kasahara, Satoshi, Keika, Kunihiro, Yokota, Shoichiro, Shinohara, Iku, Hori, Tomo, and Shprits, Yuri

Abstract

The hazardous plasma environment surrounding Earth poses risks to satellites due to internal charging and surface charging effects. Accurate predictions of these risks are crucial for minimizing damage and preparing for system failures of satellites. To forecast the plasma environment, it is essential to know the current state of the system, as the accuracy of the forecast depends on the accuracy of the initial condition of the forecast. In this study, we use data assimilation techniques to combine observational data and model predictions, and present the first global validation of a data-assimilative electron ring current nowcast during a geomagnetic storm. By assimilating measurements from one satellite and validating the results against another satellite in a different magnetic local time sector, we assess the global response and effectiveness of the data assimilation technique for space weather applications. Using this method, we found that the simulation accuracy can be drastically improved at times when observations are available while eliminating almost all of the bias previously present in the model. These findings contribute to the construction of improved operational models in estimating surface charging risks and providing realistic source populations for radiation belt simulations.

Published
2024

9. Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.

Author

Cellini, Barbara, Pampalone, Gioena, Camaioni, Emidio, Pariano, Marilena, Catalano, Flavia, Zelante, Teresa, Dindo, Mirco, Macchioni, Lara, Di Veroli, Alessandra, Galarini, Roberta, Paoletti, Fabiola, Davidescu, Magdalena, Stincardini, Claudia, Vascelli, Gianluca, Bellet, Marina, Saba, Julie, Giovagnoli, Stefano, Giardina, Giorgio, Romani, Luigina, and Costantini, Claudio

Subjects
Humans, Animals, Mice, Cystic Fibrosis, Cystic Fibrosis Transmembrane Conductance Regulator, Antifungal Agents, Feasibility Studies, Inflammation, Anti-Inflammatory Agents
Abstract

Cystic fibrosis (CF) is an autosomal recessive disorder characterized by respiratory failure due to a vicious cycle of defective Cystic Fibrosis Transmembrane conductance Regulator (CFTR) function, chronic inflammation and recurrent bacterial and fungal infections. Although the recent introduction of CFTR correctors/potentiators has revolutionized the clinical management of CF patients, resurgence of inflammation and persistence of pathogens still posit a major concern and should be targeted contextually. On the background of a network-based selectivity that allows to target the same enzyme in the host and microbes with different outcomes, we focused on sphingosine-1-phosphate (S1P) lyase (SPL) of the sphingolipid metabolism as a potential candidate to uniquely induce anti-inflammatory and antifungal activities in CF. As a feasibility study, herein we show that interfering with S1P metabolism improved the immune response in a murine model of CF with aspergillosis while preventing germination of Aspergillus fumigatus conidia. In addition, in an early drug discovery process, we purified human and A. fumigatus SPL, characterized their biochemical and structural properties, and performed an in silico screening to identify potential dual species SPL inhibitors. We identified two hits behaving as competitive inhibitors of pathogen and host SPL, thus paving the way for hit-to-lead and translational studies for the development of drug candidates capable of restraining fungal growth and increasing antifungal resistance.

Published
2023

13. Analysis of metabolites associated with ADIPOQ genotypes in individuals with type 2 diabetes mellitus

Author

Diniz, Tainá Gomes, de Assis, Caroline Severo, de Sousa, Bruno Rafael Virginio, Batista, Kamila Sabino, Silva, Alexandre Sérgio, de Queiroga Evangelista, Isabella Wanderley, Viturino, Marina Gonçalves Monteiro, do Nascimento, Yuri Mangueira, da Silva, Evandro Ferreira, Tavares, Josean Fechine, Monteiro, Mussara Gomes Cavalcanti Alves, dos Santos Fechine, Carla Patricia Novaes, e Silva, Anauara Lima, and Persuhn, Darlene Camati

Published
2024
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17. Characterization of H5N1 avian influenza virus isolated from bird in Russia with the E627K mutation in the PB2 protein

Author

Marchenko, Vasiliy Yu., Panova, Anastasia S., Kolosova, Natalia P., Gudymo, Andrey S., Svyatchenko, Svetlana V., Danilenko, Alexey V., Vasiltsova, Natalia N., Egorova, Marina L., Onkhonova, Galina S., Zhestkov, Pavel D., Zinyakov, Nikolay G., Andreychuk, Dmitriy B., Chvala, Ilya A., Kosenko, Maksim N., Moiseeva, Anastasia A., Boldyrev, Nikita D., Shadrinova, Kiunnei N., Perfilieva, Olga N., and Ryzhikov, Alexander B.

Published
2024
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24. H3K9me3 demethylation by JMJD2B is regulated by pirfenidone resulting in improved NASH

Author

Rodriguez-Sanabria, J. Samael, Rosas-Campos, Rebeca, Vázquez-Esqueda, Ángel, Palacios-Marín, Ivonne, Jiménez-Chillaron, Josep, Escutia-Gutiérrez, Rebeca, Jave-Suarez, Luis Felipe, Galicia-Moreno, Marina, Monroy-Ramirez, Hugo Christian, Cerda-Reyes, Eira, Almeida-López, Mónica, Martinez-Lopez, Erika, Herrera, Luis Alonso, Armendáriz-Borunda, Juan, and Sandoval-Rodriguez, Ana

Published
2024
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47. Publisher Correction: First large-scale study reveals important losses of managed honey bee and stingless bee colonies in Latin America

Author

Requier, Fabrice, Leyton, Malena Sibaja, Morales, Carolina L., Garibaldi, Lucas A., Giacobino, Agostina, Porrini, Martin Pablo, Rosso-Londoño, Juan Manuel, Velarde, Rodrigo A., Aignasse, Andrea, Aldea-Sánchez, Patricia, Allasino, Mariana Laura, Arredondo, Daniela, Audisio, Carina, Cagnolo, Natalia Bulacio, Basualdo, Marina, Branchiccela, Belén, Calderón, Rafael A., Castelli, Loreley, Castilhos, Dayson, Escareño, Francisca Contreras, Correa-Benítez, Adriana, da Silva, Fabiana Oliveira, Garnica, Diego Silva, de Groot, Grecia, Delgado-Cañedo, Andres, Fernández-Marín, Hermógenes, Freitas, Breno M., Galindo-Cardona, Alberto, Garcia, Nancy, Garrido, Paula M., Giray, Tugrul, Gonçalves, Lionel Segui, Landi, Lucas, Malusá Gonçalves, Daniel, Martinez, Silvia Inés, Moja, Pablo Joaquín, Molineri, Ana, Müller, Pablo Fernando, Nogueira, Enrique, Pacini, Adriana, Palacio, María Alejandra, Parra, Guiomar Nates, Parra-H, Alejandro, Peres Gramacho, Kátia, Castro, Eleazar Pérez, Pires, Carmen Sílvia Soares, Reynaldi, Francisco J., Luis, Anais Rodríguez, Rossini, Carmen, Sánchez Armijos, Milton, Santos, Estela, Scannapieco, Alejandra, Spina, Yamandú Mendoza, Tapia González, José María, Vargas Fernández, Andrés Marcelo, Viana, Blandina Felipe, Vieli, Lorena, Yadró García, Carlos Ariel, and Antúnez, Karina

Published
2024
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