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2 results on '"Marilena Greco"'

1. sFlt-1 and CA 15.3 are indicators of endothelial damage and pulmonary fibrosis in SARS-CoV-2 infection

Author

Marilena Greco, Salvatore Suppressa, Roberta Assunta Lazzari, Fernando Sicuro, Carmelo Catanese, and Giambattista Lobreglio

Subjects
Medicine, Science
Abstract

Abstract COVID-19 pandemic led to a worldwide increase of hospitalizations for interstitial pneumonia with thrombosis complications, endothelial injury and multiorgan disease. Common CT findings include lung bilateral infiltrates, bilateral ground-glass opacities and/or consolidation whilst no current laboratory parameter consents rapidly evaluation of COVID-19 risk and disease severity. In the present work we investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis. Serum sFlt-1 has been associated with endothelial injury and sepsis severity, CA 15.3 seems an alternative marker for KL-6 for fibrotic lung diseases and pulmonary interstitial damage. We analysed 262 SARS-CoV-2 patients with differing levels of clinical severity; we found an association of serum sFlt-1 (ROC AUC 0.902, decision threshold > 90.3 pg/mL, p 24.8 U/mL, p

Published
2021
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2. sFlt-1 and CA 15.3 are indicators of endothelial damage and pulmonary fibrosis in SARS-CoV-2 infection

Author

Fernando Sicuro, Marilena Greco, Giambattista Lobreglio, Salvatore Suppressa, Carmelo Catanese, and Roberta Assunta Lazzari

Subjects
Male, medicine.medical_specialty, Pulmonary Fibrosis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Science, CA 15-3, Diseases, Disease, Gastroenterology, Article, Sepsis, Medical research, Internal medicine, Pulmonary fibrosis, medicine, Humans, Stage (cooking), Aged, Vascular Endothelial Growth Factor Receptor-1, Multidisciplinary, Lung, SARS-CoV-2, business.industry, Mucin-1, Health care, COVID-19, Middle Aged, medicine.disease, Thrombosis, medicine.anatomical_structure, Medicine, Female, Lung Diseases, Interstitial, business, Biomarkers
Abstract

COVID-19 pandemic led to a worldwide increase of hospitalizations for interstitial pneumonia with thrombosis complications, endothelial injury and multiorgan disease. Common CT findings include lung bilateral infiltrates, bilateral ground-glass opacities and/or consolidation whilst no current laboratory parameter consents rapidly evaluation of COVID-19 risk and disease severity. In the present work we investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis. Serum sFlt-1 has been associated with endothelial injury and sepsis severity, CA 15.3 seems an alternative marker for KL-6 for fibrotic lung diseases and pulmonary interstitial damage. We analysed 262 SARS-CoV-2 patients with differing levels of clinical severity; we found an association of serum sFlt-1 (ROC AUC 0.902, decision threshold > 90.3 pg/mL, p p 24.8 U/mL, p

Published
2021

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