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Your search keyword '"M. Tyler Nelson"' showing total 2 results
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1. Examining cellular responses to reconstituted antibody protein liquids

Author

M. Tyler Nelson, Joseph M. Slocik, Eric J. Romer, Cassandra I. Mankus, Richard T. Agans, Rajesh R. Naik, and Saber M. Hussain

Subjects
Medicine, Science
Abstract

Abstract Protein ionic liquids (PIL) are a new class of biologic stabilizers designed to protect the functionality and extend the shelf-life of biotechnological and therapeutic agents making them more readily available, and resistant to austere environments. Protein biorecognition elements such as monoclonal antibodies are commonly utilized therapeutics that require the robust stabilization offered by PILs, but biocompatibility remains an important issue. This study has focused on characterizing the biocompatibility of an antibody based PIL by exposing multiple cells types to a cationized immunoglobulin suspended in an anionic liquid (IgG-IL). The IgG-IL caused no significant alterations in cellular health for all three cell types with treatments

Published
2021
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2. Examining cellular responses to reconstituted antibody protein liquids

Author

Cassandra I. Mankus, Rajesh R. Naik, Richard Agans, Joseph M. Slocik, M. Tyler Nelson, Eric J. Romer, and Saber M. Hussain

Subjects
Cell biology, Cell type, Programmed cell death, Biocompatibility, Molecular biology, medicine.drug_class, Science, Ionic Liquids, Monoclonal antibody, Biochemistry, Article, Engineering, Nanoscience and technology, medicine, HaCaT Cells, Humans, Cytotoxicity, Caspase, Multidisciplinary, Cell Death, biology, Protein Stability, Chemistry, Biological techniques, Interleukin-8, Hep G2 Cells, Oxidants, Chemical biology, Materials science, Oxidative Stress, HaCaT, A549 Cells, Immunoglobulin G, biology.protein, Medicine, Antibody, Biotechnology
Abstract

Protein ionic liquids (PIL) are a new class of biologic stabilizers designed to protect the functionality and extend the shelf-life of biotechnological and therapeutic agents making them more readily available, and resistant to austere environments. Protein biorecognition elements such as monoclonal antibodies are commonly utilized therapeutics that require the robust stabilization offered by PILs, but biocompatibility remains an important issue. This study has focused on characterizing the biocompatibility of an antibody based PIL by exposing multiple cells types to a cationized immunoglobulin suspended in an anionic liquid (IgG-IL). The IgG-IL caused no significant alterations in cellular health for all three cell types with treatments

Published
2021

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