Search

Your search keyword '"Lyytikäinen, Leo‐Pekka"' showing total 19 results
Start Over Author "Lyytikäinen, Leo‐Pekka" Journal scientific reports
19 results on '"Lyytikäinen, Leo‐Pekka"'

2. Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

Author

Weng, Lu-Chen, Lunetta, Kathryn L, Müller-Nurasyid, Martina, Smith, Albert Vernon, Thériault, Sébastien, Weeke, Peter E, Barnard, John, Bis, Joshua C, Lyytikäinen, Leo-Pekka, Kleber, Marcus E, Martinsson, Andreas, Lin, Henry J, Rienstra, Michiel, Trompet, Stella, Krijthe, Bouwe P, Dörr, Marcus, Klarin, Derek, Chasman, Daniel I, Sinner, Moritz F, Waldenberger, Melanie, Launer, Lenore J, Harris, Tamara B, Soliman, Elsayed Z, Alonso, Alvaro, Paré, Guillaume, Teixeira, Pedro L, Denny, Joshua C, Shoemaker, M Benjamin, Van Wagoner, David R, Smith, Jonathan D, Psaty, Bruce M, Sotoodehnia, Nona, Taylor, Kent D, Kähönen, Mika, Nikus, Kjell, Delgado, Graciela E, Melander, Olle, Engström, Gunnar, Yao, Jie, Guo, Xiuqing, Christophersen, Ingrid E, Ellinor, Patrick T, Geelhoed, Bastiaan, Verweij, Niek, Macfarlane, Peter, Ford, Ian, Heeringa, Jan, Franco, Oscar H, Uitterlinden, André G, Völker, Uwe, Teumer, Alexander, Rose, Lynda M, Kääb, Stefan, Gudnason, Vilmundur, Arking, Dan E, Conen, David, Roden, Dan M, Chung, Mina K, Heckbert, Susan R, Benjamin, Emelia J, Lehtimäki, Terho, März, Winfried, Smith, J Gustav, Rotter, Jerome I, van der Harst, Pim, Jukema, J Wouter, Stricker, Bruno H, Felix, Stephan B, Albert, Christine M, and Lubitz, Steven A

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Heart Disease, Cardiovascular, Prevention, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Age Factors, Aged, Atrial Fibrillation, Body Mass Index, Chromosomes, Human, Pair 4, Epistasis, Genetic, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypertension, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Reproducibility of Results, Risk Factors, Sex Characteristics
Abstract

It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10-5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10-8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk.

Published
2017

5. Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes

Author

Mononen, Nina, Lyytikäinen, Leo-Pekka, Seppälä, Ilkka, Mishra, Pashupati P., Juonala, Markus, Waldenberger, Melanie, Klopp, Norman, Illig, Thomas, Leiviskä, Jaana, Loo, Britt-Marie, Laaksonen, Reijo, Oksala, Niku, Kähönen, Mika, Hutri-Kähönen, Nina, Raitakari, Olli, Lehtimäki, Terho, and Raitoharju, Emma

Published
2019
Full Text
View/download PDF

8. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Author

Gorski, Mathias, van der Most, Peter J., Teumer, Alexander, Chu, Audrey Y., Li, Man, Mijatovic, Vladan, Nolte, Ilja M., Cocca, Massimiliano, Taliun, Daniel, Gomez, Felicia, Li, Yong, Tayo, Bamidele, Tin, Adrienne, Feitosa, Mary F., Aspelund, Thor, Attia, John, Biffar, Reiner, Bochud, Murielle, Boerwinkle, Eric, Borecki, Ingrid, Bottinger, Erwin P., Chen, Ming-Huei, Chouraki, Vincent, Ciullo, Marina, Coresh, Josef, Cornelis, Marilyn C., Curhan, Gary C., d’Adamo, Adamo Pio, Dehghan, Abbas, Dengler, Laura, Ding, Jingzhong, Eiriksdottir, Gudny, Endlich, Karlhans, Enroth, Stefan, Esko, Tõnu, Franco, Oscar H., Gasparini, Paolo, Gieger, Christian, Girotto, Giorgia, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hancock, Stephen J., Harris, Tamara B., Helmer, Catherine, Höllerer, Simon, Hofer, Edith, Hofman, Albert, Holliday, Elizabeth G., Homuth, Georg, Hu, Frank B., Huth, Cornelia, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Imboden, Medea, Johansson, Åsa, Kähönen, Mika, König, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kumar, Ashish, Kutalik, Zoltan, Lambert, Jean-Charles, Launer, Lenore J., Lehtimäki, Terho, de Borst, Martin H., Navis, Gerjan, Swertz, Morris, Liu, Yongmei, Lohman, Kurt, Loos, Ruth J. F., Lu, Yingchang, Lyytikäinen, Leo-Pekka, McEvoy, Mark A., Meisinger, Christa, Meitinger, Thomas, Metspalu, Andres, Metzger, Marie, Mihailov, Evelin, Mitchell, Paul, Nauck, Matthias, Oldehinkel, Albertine J., Olden, Matthias, WJH Penninx, Brenda, Pistis, Giorgio, Pramstaller, Peter P., Probst-Hensch, Nicole, Raitakari, Olli T., Rettig, Rainer, Ridker, Paul M., Rivadeneira, Fernando, Robino, Antonietta, Rosas, Sylvia E., Ruderfer, Douglas, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia, Schmidt, Helena, Schmidt, Reinhold, Scott, Rodney J., Sedaghat, Sanaz, Smith, Albert V., Sorice, Rossella, Stengel, Benedicte, Stracke, Sylvia, Strauch, Konstantin, Toniolo, Daniela, Uitterlinden, Andre G., Ulivi, Sheila, Viikari, Jorma S., Völker, Uwe, Vollenweider, Peter, Völzke, Henry, Vuckovic, Dragana, Waldenberger, Melanie, Jin Wang, Jie, Yang, Qiong, Chasman, Daniel I., Tromp, Gerard, Snieder, Harold, Heid, Iris M., Fox, Caroline S., Köttgen, Anna, Pattaro, Cristian, Böger, Carsten A., and Fuchsberger, Christian

Published
2017
Full Text
View/download PDF

9. Genetic Relationship between Schizophrenia and Nicotine Dependence

Author

Chen, Jingchun, Bacanu, S. A., Yu, H., Zhao, Z., Jia, P., Kendler, K. S., Kranzler, H. R., Gelernter, J., Farrer, L., Minica, C., Pool, R., Milaneschi, Y., Boomsma, D. I., Penninx, B. W., Tyndale, R. F., Ware, J. J., Vink, J. M., Kaprio, Jaakko, Munafo, M., Chen, X., Loukola, Anu, Mangino, M., Menni, C., Chen, J., Peterson, R., Auro, Kirsi, Lyytikäinen, Leo-Pekka, Wedenoja, Juho, Stiby, A. I., Hemani, G., Willemsen, G., Hottenga, J. J., Korhonen, Tellervo, Heliövaara, Markku, Perola, Markus, Rose, R., Paternoster, L., Timpson, N., Wassenaar, C. A., Zhu, A. Z., Smith, G. D., Raitakari, Olli, Lehtimäki, Terho, Kähönen, Mika, Koskinen, Seppo, Spector, T., Salomaa, Veikko, Taylor, M., Maes, H., Riley, B., Sherva, R., Maher, B., Vanyukov, M., Biological Psychology, EMGO+ - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Sociology and Social Gerontology, Psychiatry, EMGO - Mental health, Amsterdam Neuroscience - Complex Trait Genetics, Institute for Molecular Medicine Finland, Department of Public Health, and Genetic Epidemiology

Subjects
Male, Netherlands Twin Register (NTR), 0301 basic medicine, Genome-wide association study, Brain and Behaviour, Bioinformatics, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Polymorphism (computer science), Gene Regulatory Networks, Cotinine, RISK, Genetics, Multidisciplinary, Tobacco and Alcohol, COMMON VARIANTS, BIPOLAR DISORDER, Tobacco Use Disorder, 3142 Public health care science, environmental and occupational health, FALSE DISCOVERY RATE, 3. Good health, Schizophrenia, Female, LONG-TERM POTENTIATION, SMOKERS, Signal Transduction, Fagerstrom Test for Nicotine Dependence, RBFOX1, Biology, Polymorphism, Single Nucleotide, Risk Assessment, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, mental disorders, medicine, Humans, SMOKING-BEHAVIOR, TOBACCO SMOKING, Bipolar disorder, GENOME-WIDE ASSOCIATION, Gene, RECEPTOR SUBUNIT GENE, ta1184, medicine.disease, ta3124, 030104 developmental biology, chemistry, 3111 Biomedicine, Developmental Psychopathology, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

It is well known that most schizophrenia patients smoke cigarettes. There are different hypotheses postulating the underlying mechanisms of this comorbidity. We used summary statistics from large meta-analyses of plasma cotinine concentration (COT), Fagerström test for nicotine dependence (FTND) and schizophrenia to examine the genetic relationship between these traits. We found that schizophrenia risk scores calculated at P-value thresholds of 5 × 10−3 and larger predicted FTND and cigarettes smoked per day (CPD), suggesting that genes most significantly associated with schizophrenia were not associated with FTND/CPD, consistent with the self-medication hypothesis. The COT risk scores predicted schizophrenia diagnosis at P-values of 5 × 10−3 and smaller, implying that genes most significantly associated with COT were associated with schizophrenia. These results implicated that schizophrenia and FTND/CPD/COT shared some genetic liability. Based on this shared liability, we identified multiple long non-coding RNAs and RNA binding protein genes (DA376252, BX089737, LOC101927273, LINC01029, LOC101928622, HY157071, DA902558, RBFOX1 and TINCR), protein modification genes (MANBA, UBE2D3, and RANGAP1) and energy production genes (XYLB, MTRF1 and ENOX1) that were associated with both conditions. Further analyses revealed that these shared genes were enriched in calcium signaling, long-term potentiation and neuroactive ligand-receptor interaction pathways that played a critical role in cognitive functions and neuronal plasticity.

Published
2016

10. Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm – The Tampere Vascular Study

Author

Sulkava, Miska, primary, Raitoharju, Emma, additional, Mennander, Ari, additional, Levula, Mari, additional, Seppälä, Ilkka, additional, Lyytikäinen, Leo-Pekka, additional, Järvinen, Otso, additional, Illig, Thomas, additional, Klopp, Norman, additional, Mononen, Nina, additional, Laaksonen, Reijo, additional, Kähönen, Mika, additional, Oksala, Niku, additional, and Lehtimäki, Terho, additional

Published
2017
Full Text
View/download PDF

11. Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Author

Gorski, Mathias, primary, Most, Peter J. van der, additional, Teumer, Alexander, additional, Chu, Audrey Y., additional, Li, Man, additional, Mijatovic, Vladan, additional, Nolte, Ilja M., additional, Cocca, Massimiliano, additional, Taliun, Daniel, additional, Gomez, Felicia, additional, Li, Yong, additional, Tayo, Bamidele, additional, Tin, Adrienne, additional, Feitosa, Mary F., additional, Aspelund, Thor, additional, Attia, John, additional, Biffar, Reiner, additional, Bochud, Murielle, additional, Boerwinkle, Eric, additional, Borecki, Ingrid, additional, Bottinger, Erwin P., additional, Chen, Ming-Huei, additional, Chouraki, Vincent, additional, Ciullo, Marina, additional, Coresh, Josef, additional, Cornelis, Marilyn C., additional, Curhan, Gary C., additional, Adamo, Adamo Pio d’, additional, Dehghan, Abbas, additional, Dengler, Laura, additional, Ding, Jingzhong, additional, Eiriksdottir, Gudny, additional, Endlich, Karlhans, additional, Enroth, Stefan, additional, Esko, Tõnu, additional, Franco, Oscar H., additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Girotto, Giorgia, additional, Gottesman, Omri, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hancock, Stephen J., additional, Harris, Tamara B., additional, Helmer, Catherine, additional, Höllerer, Simon, additional, Hofer, Edith, additional, Hofman, Albert, additional, Holliday, Elizabeth G., additional, Homuth, Georg, additional, Hu, Frank B., additional, Huth, Cornelia, additional, Hutri-Kähönen, Nina, additional, Hwang, Shih-Jen, additional, Imboden, Medea, additional, Johansson, Åsa, additional, Kähönen, Mika, additional, König, Wolfgang, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kumar, Ashish, additional, Kutalik, Zoltan, additional, Lambert, Jean-Charles, additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, de Borst, Martin H., additional, Navis, Gerjan, additional, Swertz, Morris, additional, Liu, Yongmei, additional, Lohman, Kurt, additional, Loos, Ruth J. F., additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, McEvoy, Mark A., additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Metzger, Marie, additional, Mihailov, Evelin, additional, Mitchell, Paul, additional, Nauck, Matthias, additional, Oldehinkel, Albertine J., additional, Olden, Matthias, additional, WJH Penninx, Brenda, additional, Pistis, Giorgio, additional, Pramstaller, Peter P., additional, Probst-Hensch, Nicole, additional, Raitakari, Olli T., additional, Rettig, Rainer, additional, Ridker, Paul M., additional, Rivadeneira, Fernando, additional, Robino, Antonietta, additional, Rosas, Sylvia E., additional, Ruderfer, Douglas, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sala, Cinzia, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Scott, Rodney J., additional, Sedaghat, Sanaz, additional, Smith, Albert V., additional, Sorice, Rossella, additional, Stengel, Benedicte, additional, Stracke, Sylvia, additional, Strauch, Konstantin, additional, Toniolo, Daniela, additional, Uitterlinden, Andre G., additional, Ulivi, Sheila, additional, Viikari, Jorma S., additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Vuckovic, Dragana, additional, Waldenberger, Melanie, additional, Wang, Jie Jin, additional, Yang, Qiong, additional, Chasman, Daniel I., additional, Tromp, Gerard, additional, Snieder, Harold, additional, Heid, Iris M., additional, Fox, Caroline S., additional, Köttgen, Anna, additional, Pattaro, Cristian, additional, Böger, Carsten A., additional, and Fuchsberger, Christian, additional

Published
2017
Full Text
View/download PDF

12. Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques – Tampere Vascular Study

Author

Sulkava, Miska, primary, Raitoharju, Emma, additional, Levula, Mari, additional, Seppälä, Ilkka, additional, Lyytikäinen, Leo-Pekka, additional, Mennander, Ari, additional, Järvinen, Otso, additional, Zeitlin, Rainer, additional, Salenius, Juha-Pekka, additional, Illig, Thomas, additional, Klopp, Norman, additional, Mononen, Nina, additional, Laaksonen, Reijo, additional, Kähönen, Mika, additional, Oksala, Niku, additional, and Lehtimäki, Terho, additional

Published
2017
Full Text
View/download PDF

13. Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study

Author

Raitoharju, Emma, primary, Seppälä, Ilkka, additional, Lyytikäinen, Leo-Pekka, additional, Viikari, Jorma, additional, Ala-Korpela, Mika, additional, Soininen, Pasi, additional, Kangas, Antti J., additional, Waldenberger, Melanie, additional, Klopp, Norman, additional, Illig, Thomas, additional, Leiviskä, Jaana, additional, Loo, Britt-Marie, additional, Oksala, Niku, additional, Kähönen, Mika, additional, Hutri-Kähönen, Nina, additional, Laaksonen, Reijo, additional, Raitakari, Olli, additional, and Lehtimäki, Terho, additional

Published
2016
Full Text
View/download PDF

14. No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis

Author

Loley, Christina, primary, Alver, Maris, additional, Assimes, Themistocles L., additional, Bjonnes, Andrew, additional, Goel, Anuj, additional, Gustafsson, Stefan, additional, Hernesniemi, Jussi, additional, Hopewell, Jemma C., additional, Kanoni, Stavroula, additional, Kleber, Marcus E., additional, Lau, King Wai, additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, Nelson, Christopher P., additional, Nikpay, Majid, additional, Qu, Liming, additional, Salfati, Elias, additional, Scholz, Markus, additional, Tukiainen, Taru, additional, Willenborg, Christina, additional, Won, Hong-Hee, additional, Zeng, Lingyao, additional, Zhang, Weihua, additional, Anand, Sonia S., additional, Beutner, Frank, additional, Bottinger, Erwin P., additional, Clarke, Robert, additional, Dedoussis, George, additional, Do, Ron, additional, Esko, Tõnu, additional, Eskola, Markku, additional, Farrall, Martin, additional, Gauguier, Dominique, additional, Giedraitis, Vilmantas, additional, Granger, Christopher B., additional, Hall, Alistair S., additional, Hamsten, Anders, additional, Hazen, Stanley L., additional, Huang, Jie, additional, Kähönen, Mika, additional, Kyriakou, Theodosios, additional, Laaksonen, Reijo, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Magnusson, Patrik K. E., additional, Marouli, Eirini, additional, Mihailov, Evelin, additional, Morris, Andrew P., additional, Nikus, Kjell, additional, Pedersen, Nancy, additional, Rallidis, Loukianos, additional, Salomaa, Veikko, additional, Shah, Svati H., additional, Stewart, Alexandre F. R., additional, Thompson, John R., additional, Zalloua, Pierre A., additional, Chambers, John C., additional, Collins, Rory, additional, Ingelsson, Erik, additional, Iribarren, Carlos, additional, Karhunen, Pekka J., additional, Kooner, Jaspal S., additional, Lehtimäki, Terho, additional, Loos, Ruth J. F., additional, März, Winfried, additional, McPherson, Ruth, additional, Metspalu, Andres, additional, Reilly, Muredach P., additional, Ripatti, Samuli, additional, Sanghera, Dharambir K., additional, Thiery, Joachim, additional, Watkins, Hugh, additional, Deloukas, Panos, additional, Kathiresan, Sekar, additional, Samani, Nilesh J., additional, Schunkert, Heribert, additional, Erdmann, Jeanette, additional, and König, Inke R., additional

Published
2016
Full Text
View/download PDF

15. Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Author

Seppälä, Ilkka, primary, Kleber, Marcus E., additional, Bevan, Steve, additional, Lyytikäinen, Leo-Pekka, additional, Oksala, Niku, additional, Hernesniemi, Jussi A., additional, Mäkelä, Kari-Matti, additional, Rothwell, Peter M., additional, Sudlow, Cathie, additional, Dichgans, Martin, additional, Mononen, Nina, additional, Vlachopoulou, Efthymia, additional, Sinisalo, Juha, additional, Delgado, Graciela E., additional, Laaksonen, Reijo, additional, Koskinen, Tuomas, additional, Scharnagl, Hubert, additional, Kähönen, Mika, additional, Markus, Hugh S., additional, März, Winfried, additional, and Lehtimäki, Terho, additional

Published
2016
Full Text
View/download PDF

16. Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2

Author

Ware, Jennifer J., primary, Chen, Xiangning, additional, Vink, Jacqueline, additional, Loukola, Anu, additional, Minica, Camelia, additional, Pool, Rene, additional, Milaneschi, Yuri, additional, Mangino, Massimo, additional, Menni, Cristina, additional, Chen, Jingchun, additional, Peterson, Roseann E., additional, Auro, Kirsi, additional, Lyytikäinen, Leo-Pekka, additional, Wedenoja, Juho, additional, Stiby, Alexander I., additional, Hemani, Gibran, additional, Willemsen, Gonneke, additional, Hottenga, Jouke Jan, additional, Korhonen, Tellervo, additional, Heliövaara, Markku, additional, Perola, Markus, additional, Rose, Richard J., additional, Paternoster, Lavinia, additional, Timpson, Nic, additional, Wassenaar, Catherine A., additional, Zhu, Andy Z. X., additional, Davey Smith, George, additional, T. Raitakari, Olli, additional, Lehtimäki, Terho, additional, Kähönen, Mika, additional, Koskinen, Seppo, additional, Spector, Timothy, additional, Penninx, Brenda W. J. H., additional, Salomaa, Veikko, additional, Boomsma, Dorret I., additional, Tyndale, Rachel F., additional, Kaprio, Jaakko, additional, and Munafò, Marcus R., additional

Published
2016
Full Text
View/download PDF

17. Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque

Author

Fan, Yue-Mei, primary, Hernesniemi, Jussi, additional, Oksala, Niku, additional, Levula, Mari, additional, Raitoharju, Emma, additional, Collings, Auni, additional, Hutri-Kähönen, Nina, additional, Juonala, Markus, additional, Marniemi, Jukka, additional, Lyytikäinen, Leo-Pekka, additional, Seppälä, Ilkka, additional, Mennander, Ari, additional, Tarkka, Matti, additional, Kangas, Antti J., additional, Soininen, Pasi, additional, Salenius, Juha Pekka, additional, Klopp, Norman, additional, Illig, Thomas, additional, Laitinen, Tomi, additional, Ala-Korpela, Mika, additional, Laaksonen, Reijo, additional, Viikari, Jorma, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, and Lehtimäki, Terho, additional

Published
2014
Full Text
View/download PDF

18. Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.

Author

Yue-Mei Fan, Hernesniemi, Jussi, Oksala, Niku, Levula, Mari, Raitoharju, Emma, Collings, Auni, Hutri-Kähönen, Nina, Juonala, Markus, Marniemi, Jukka, Lyytikäinen, Leo-Pekka, Seppälä, Ilkka, Mennander, Ari, Tarkka, Matti, Kangas, Antti J., Soininen, Pasi, Salenius, Juha Pekka, Klopp, Norman, Illig, Thomas, Laitinen, Tomi, and Ala-Korpela, Mika

Subjects
TRANSCRIPTION factors, LIPOPROTEINS, METABOLISM, ATHEROSCLEROTIC plaque, ATHEROSCLEROSIS, LIPIDS, MESSENGER RNA
Abstract

Upstream transcription factor 1 (USF1) allelic variants significantly influence future risk of cardiovascular disease and overall mortality in females. We investigated sex-specific effects of USF1 gene allelic variants on serum indices of lipoprotein metabolism, early markers of asymptomatic atherosclerosis and their changes during six years of follow-up. In addition, we investigated the cis-regulatory role of these USF1 variants in artery wall tissues in Caucasians. In the Cardiovascular Risk in Young Finns Study, 1,608 participants (56% women, aged 31.9 ± 4.9) with lipids and cIMT data were included. For functional study, whole genome mRNA expression profiling was performed in 91 histologically classified atherosclerotic samples. In females, serum total, LDL cholesterol and apoB levels increased gradually according to USF1 rs2516839 genotypes TT

Published
2014
Full Text
View/download PDF

19. Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

Author

Gorski M, Most PJV, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger EP, Chen MH, Chouraki V, Ciullo M, Coresh J, Cornelis MC, Curhan GC, Adamo AP, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco OH, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock SJ, Harris TB, Helmer C, Höllerer S, Hofer E, Hofman A, Holliday EG, Homuth G, Hu FB, Huth C, Hutri-Kähönen N, Hwang SJ, Imboden M, Johansson Å, Kähönen M, König W, Kramer H, Krämer BK, Kumar A, Kutalik Z, Lambert JC, Launer LJ, Lehtimäki T, de Borst MH, Navis G, Swertz M, Liu Y, Lohman K, Loos RJF, Lu Y, Lyytikäinen LP, McEvoy MA, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel AJ, Olden M, Wjh Penninx B, Pistis G, Pramstaller PP, Probst-Hensch N, Raitakari OT, Rettig R, Ridker PM, Rivadeneira F, Robino A, Rosas SE, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmidt R, Scott RJ, Sedaghat S, Smith AV, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden AG, Ulivi S, Viikari JS, Völker U, Vollenweider P, Völzke H, Vuckovic D, Waldenberger M, Wang JJ, Yang Q, Chasman DI, Tromp G, Snieder H, Heid IM, Fox CS, Köttgen A, Pattaro C, Böger CA, and Fuchsberger C

Abstract

This corrects the article DOI: 10.1038/srep45040.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results