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497 results on '"Lukasz A"'

1. Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsy

Author

Valentino D’Onofrio, Lotte Keulen, Annelore Vandendriessche, Jasperina Dubois, Reinoud Cartuyvels, Marie-Elena Vanden Abeele, Judith Fraussen, Patrick Vandormael, Veerle Somers, Ruth Achten, Amélie Dendooven, Ann Driessen, Lukasz Augsburg, Niels Hellings, Martin Lammens, Jan Vanrusselt, and Janneke Cox

Subjects
Medicine, Science
Abstract

Abstract The WHO defines different COVID-19 disease stages in which the pathophysiological mechanisms differ. We evaluated the characteristics of these COVID-19 disease stages. Forty-four PCR-confirmed COVID-19 patients were included in a prospective minimal invasive autopsy cohort. Patients were classified into mild-moderate (n = 4), severe-critical (n = 32) and post-acute disease (n = 8) and clinical, radiological, histological, microbiological and immunological data were compared. Classified according to Thoracic Society of America, patients with mild-moderate disease had no typical COVID-19 images on CT-Thorax versus 71.9% with typical images in severe-critical disease and 87.5% in post-acute disease (P

Published
2022
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2. Biophysical properties of a tau seed

Author

Zhiqiang Hou, Dailu Chen, Bryan D. Ryder, and Lukasz A. Joachimiak

Subjects
Medicine, Science
Abstract

Abstract Pathogenesis of tauopathies involves conversion of tau monomer into pathological tau conformers that serve as templates to recruit native tau into growing assemblies. Small soluble tau seeds have been proposed to drive pathological tau assembly in vitro, in cells and in vivo. We have previously described the isolation of monomeric pathogenic tau seeds derived from recombinant samples and tauopathy tissues but in-depth biophysical characterization of these species has not been done. Here we describe a chromatographic method to isolate recombinant soluble tau seeds derived from heparin treatment. We used biochemical and biophysical approaches to show that the seeds are predominantly monomeric and have the capacity to nucleate aggregation of inert forms of tau in vitro and in cells. Finally, we used crosslinking mass spectrometry to identify the topological changes in tau as it converts from an inert state to a pathogenic seed. Future studies will reveal the relationship between soluble seeds and structural polymorphs derived from tauopathies to help diagnose and develop therapeutics targeting specific tauopathies.

Published
2021
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20. Influence of Bi doping on the electronic structure of (Ga,Mn)As epitaxial layers

Author

Yastrubchak, Oksana, Tataryn, Nataliia, Gluba, Lukasz, Mamykin, Sergii, Sadowski, Janusz, Andrearczyk, Tomasz, Domagala, Jaroslaw Z., Kondratenko, Olga, Romanyuk, Volodymyr, Fedchenko, Olena, Lytvynenko, Yaryna, Tkach, Olena, Vasilyev, Dmitry, Babenkov, Sergey, Medjanik, Katerina, Gas, Katarzyna, Sawicki, Maciej, Wosinski, Tadeusz, Schönhense, Gerd, and Elmers, Hans-Joachim

Published
2023
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24. Evaluation of semiochemical based push-pull strategy for population suppression of ambrosia beetle vectors of laurel wilt disease in avocado.

Author

Rivera, Monique J, Martini, Xavier, Conover, Derrick, Mafra-Neto, Agenor, Carrillo, Daniel, and Stelinski, Lukasz L

Abstract

Ambrosia beetles (Coleoptera: Curculionidae: Scolytinae and Platypodinae) bore into tree xylem to complete their life cycle, feeding on symbiotic fungi. Ambrosia beetles are a threat to avocado where they have been found to vector a symbiotic fungus, Raffaelea lauricola, the causal agent of the laurel wilt disease. We assessed the repellency of methyl salicylate and verbenone to two putative laurel wilt vectors in avocado, Xyleborus volvulus (Fabricius) and Xyleborus bispinatus (Eichhoff), under laboratory conditions. Then, we tested the same two chemicals released from SPLAT flowable matrix with and without low-dose ethanol dispensers for manipulation of ambrosia beetle populations occurring in commercial avocado. The potential active space of repellents was assessed by quantifying beetle catch on traps placed 'close' (~5-10 cm) and 'far' (~1-1.5 m) away from repellent dispensers. Ambrosia beetles collected on traps associated with all in-field treatments were identified to species to assess beetle diversity and community variation. Xyleborus volvulus was not repelled by methyl salicylate (MeSA) or verbenone in laboratory assays, while X. bispinatus was repelled by MeSA but not verbenone. Ambrosia beetle trap catches were reduced in the field more when plots were treated with verbenone dispensers (SPLAT) co-deployed with low-dose ethanol dispensers than when treated with verbenone alone. Beetle diversity was highest on traps deployed with low-dose ethanol lures. The repellent treatments and ethanol lures significantly altered the species composition of beetles captured in experiment plots. Our results indicate that verbenone co-deployed with ethanol lures holds potential for manipulating ambrosia beetle vectors via push-pull management in avocado. This tactic could discourage immigration and/or population establishment of ambrosia beetles in commercial avocado and function as an additional tool for management programs of laurel wilt.

Published
2020

28. High efficacy of intensive immunochemotherapy for primary mediastinal B-cell lymphoma with prolonged follow up

Author

Romejko-Jarosinska, Joanna, Ostrowska, Beata, Dabrowska-Iwanicka, Anna, Domanska-Czyz, Katarzyna, Rymkiewicz, Grzegorz, Paszkiewicz-Kozik, Ewa, Konecki, Robert, Borawska, Anna, Druzd-Sitek, Agnieszka, Lampka, Elzbieta, Osiadacz, Wlodzimierz, Osowiecki, Michal, Popławska, Lidia, Swierkowska, Monika, Targonski, Lukasz, Tajer, Joanna, Lapinska, Grazyna, Smorczewska, Malwina, and Walewski, Jan

Published
2022
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39. Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsy

Author

D’Onofrio, Valentino, Keulen, Lotte, Vandendriessche, Annelore, Dubois, Jasperina, Cartuyvels, Reinoud, Vanden Abeele, Marie-Elena, Fraussen, Judith, Vandormael, Patrick, Somers, Veerle, Achten, Ruth, Dendooven, Amélie, Driessen, Ann, Augsburg, Lukasz, Hellings, Niels, Lammens, Martin, Vanrusselt, Jan, and Cox, Janneke

Published
2022
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40. An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12.

Author

Keasar, Chen, McGuffin, Liam J, Wallner, Björn, Chopra, Gaurav, Adhikari, Badri, Bhattacharya, Debswapna, Blake, Lauren, Bortot, Leandro Oliveira, Cao, Renzhi, Dhanasekaran, BK, Dimas, Itzhel, Faccioli, Rodrigo Antonio, Faraggi, Eshel, Ganzynkowicz, Robert, Ghosh, Sambit, Ghosh, Soma, Giełdoń, Artur, Golon, Lukasz, He, Yi, Heo, Lim, Hou, Jie, Khan, Main, Khatib, Firas, Khoury, George A, Kieslich, Chris, Kim, David E, Krupa, Pawel, Lee, Gyu Rie, Li, Hongbo, Li, Jilong, Lipska, Agnieszka, Liwo, Adam, Maghrabi, Ali Hassan A, Mirdita, Milot, Mirzaei, Shokoufeh, Mozolewska, Magdalena A, Onel, Melis, Ovchinnikov, Sergey, Shah, Anand, Shah, Utkarsh, Sidi, Tomer, Sieradzan, Adam K, Ślusarz, Magdalena, Ślusarz, Rafal, Smadbeck, James, Tamamis, Phanourios, Trieber, Nicholas, Wirecki, Tomasz, Yin, Yanping, Zhang, Yang, Bacardit, Jaume, Baranowski, Maciej, Chapman, Nicholas, Cooper, Seth, Defelicibus, Alexandre, Flatten, Jeff, Koepnick, Brian, Popović, Zoran, Zaborowski, Bartlomiej, Baker, David, Cheng, Jianlin, Czaplewski, Cezary, Delbem, Alexandre Cláudio Botazzo, Floudas, Christodoulos, Kloczkowski, Andrzej, Ołdziej, Stanislaw, Levitt, Michael, Scheraga, Harold, Seok, Chaok, Söding, Johannes, Vishveshwara, Saraswathi, Xu, Dong, Foldit Players consortium, and Crivelli, Silvia N

Subjects
Foldit Players consortium, Humans, Caspases, Computational Biology, Protein Conformation, Models, Molecular, Software, Caspase 12, Models, Molecular, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test the strengths and weaknesses of their computational methods. CASP has significantly advanced the field but many hurdles still remain, which may require new ideas and collaborations. In 2012 a web-based effort called WeFold, was initiated to promote collaboration within the CASP community and attract researchers from other fields to contribute new ideas to CASP. Members of the WeFold coopetition (cooperation and competition) participated in CASP as individual teams, but also shared components of their methods to create hybrid pipelines and actively contributed to this effort. We assert that the scale and diversity of integrative prediction pipelines could not have been achieved by any individual lab or even by any collaboration among a few partners. The models contributed by the participating groups and generated by the pipelines are publicly available at the WeFold website providing a wealth of data that remains to be tapped. Here, we analyze the results of the 2014 and 2016 pipelines showing improvements according to the CASP assessment as well as areas that require further adjustments and research.

Published
2018

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