29 results on '"Llorca, J."'
Search Results
2. Influence of the drying mode of support on the properties of Pd/Al2O3–ZrO2 materials used for methane combustion.
- Author
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Amairia, C., Fessi, S., Mhamdi, M., Ghorbel, A., and Llorca, J.
- Subjects
ZIRCONIUM catalysts ,COMBUSTION ,ZIRCONIUM oxide ,METHANE ,SOL-gel processes ,PALLADIUM catalysts ,STEAM reforming - Abstract
This work constitutes a new trial to enhance the properties of palladium supported on alumina modified with zirconium used as catalysts for methane combustion. The effect of the support drying mode is studied. For this aim, Al
2 O3 -ZrO2 binary oxides with zirconium loading of 2 and 5% in weight were prepared using sol–gel process then dried under ordinary or supercritical conditions. Palladium with a loading of 0.5% was deposited on the support by wet impregnation. Several techniques have been used to investigate differences between the two types of the derived catalysts. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
3. Hydrogen production by Tuning the Photonic Band Gap with the Electronic Band Gap of TiO2
- Author
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Waterhouse, G. I. N., primary, Wahab, A. K., additional, Al-Oufi, M., additional, Jovic, V., additional, Anjum, D. H., additional, Sun-Waterhouse, D., additional, Llorca, J., additional, and Idriss, H., additional
- Published
- 2013
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- View/download PDF
4. Hydrogen production by Tuning the Photonic Band Gap with the Electronic Band Gap of TiO2.
- Author
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Waterhouse, G. I. N., Wahab, A. K., Al-Oufi, M., Jovic, V., Anjum, D. H., Sun-Waterhouse, D., Llorca, J., and Idriss, H.
- Subjects
PHOTONIC band gap structures ,ELECTRONIC band structure ,HYDROGEN production ,TITANIUM dioxide crystals ,PHOTOCATALYSTS ,TRANSMISSION electron microscopy ,SILVER nanoparticles - Abstract
Tuning the photonic band gap (PBG) to the electronic band gap (EBG) of Au/TiO
2 catalysts resulted in considerable enhancement of the photocatalytic water splitting to hydrogen under direct sunlight. Au/TiO2 (PBG-357 nm) photocatalyst exhibited superior photocatalytic performance under both UV and sunlight compared to the Au/TiO2 (PBG-585 nm) photocatalyst and both are higher than Au/TiO2 without the 3 dimensionally ordered macro-porous structure materials. The very high photocatalytic activity is attributed to suppression of a fraction of electron-hole recombination route due to the co-incidence of the PBG with the EBG of TiO2 These materials that maintain their activity with very small amount of sacrificial agents (down to 0.5 vol.% of ethanol) are poised to find direct applications because of their high activity, low cost of the process, simplicity and stability [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
5. Hydrogen production by Tuning the Photonic Band Gap with the Electronic Band Gap of TiO2.
- Author
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Waterhouse, G. I. N., Wahab, A. K., Al-Oufi, M., Jovic, V., Anjum, D. H., Sun-Waterhouse, D., Llorca, J., and Idriss, H.
- Subjects
- *
PHOTONIC band gap structures , *ELECTRONIC band structure , *HYDROGEN production , *TITANIUM dioxide crystals , *PHOTOCATALYSTS , *TRANSMISSION electron microscopy , *SILVER nanoparticles - Abstract
Tuning the photonic band gap (PBG) to the electronic band gap (EBG) of Au/TiO2 catalysts resulted in considerable enhancement of the photocatalytic water splitting to hydrogen under direct sunlight. Au/TiO2 (PBG-357 nm) photocatalyst exhibited superior photocatalytic performance under both UV and sunlight compared to the Au/TiO2 (PBG-585 nm) photocatalyst and both are higher than Au/TiO2 without the 3 dimensionally ordered macro-porous structure materials. The very high photocatalytic activity is attributed to suppression of a fraction of electron-hole recombination route due to the co-incidence of the PBG with the EBG of TiO2 These materials that maintain their activity with very small amount of sacrificial agents (down to 0.5 vol.% of ethanol) are poised to find direct applications because of their high activity, low cost of the process, simplicity and stability [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
6. Author Correction: BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis.
- Author
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Prieto-Peña D, Genre F, Remuzgo-Martínez S, Pulito-Cueto V, Atienza-Mateo B, Llorca J, Sevilla-Pérez B, Ortego-Centeno N, Lera-Gómez L, Leonardo MT, Peñalba A, Narváez J, Martín-Penagos L, Rodrigo E, Miranda-Filloy JA, Caminal-Montero L, Collado P, Pérez JS, Argila D, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Agirregoikoa E, Gualillo O, Martín J, Castañeda S, Blanco R, González-Gay MA, and López-Mejías R
- Published
- 2021
- Full Text
- View/download PDF
7. Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis.
- Author
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Prieto-Peña D, Remuzgo-Martínez S, Genre F, Pulito-Cueto V, Atienza-Mateo B, Llorca J, Sevilla-Pérez B, Ortego-Centeno N, Marquez A, Lera-Gómez L, Leonardo MT, Peñalba A, Narváez J, Martín-Penagos L, Rodrigo E, Miranda-Filloy JA, Caminal-Montero L, Collado P, Sánchez Pérez J, de Argila D, Rubio E, León Luque M, Blanco-Madrigal JM, Galíndez-Agirregoikoa E, Gualillo O, Martín J, Castañeda S, Blanco R, González-Gay MA, and López-Mejías R
- Subjects
- Adolescent, Case-Control Studies, Child, Female, Gene Frequency, Gene Regulatory Networks, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, IgA Vasculitis etiology, Male, Polymorphism, Single Nucleotide, Signal Transduction genetics, Signal Transduction immunology, Young Adult, IgA Vasculitis genetics, IgA Vasculitis immunology, Immunoglobulin A metabolism, Interleukin-1 Receptor-Like 1 Protein genetics, Interleukin-1 Receptor-Like 1 Protein immunology, Interleukin-33 genetics, Interleukin-33 immunology
- Abstract
Cytokines signalling pathway genes are crucial factors of the genetic network underlying the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence of the interleukin (IL)33- IL1 receptor like (IL1RL)1 signalling pathway on the increased risk of several immune-mediated diseases has been described. Accordingly, we assessed whether the IL33-IL1RL1 pathway represents a novel genetic risk factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) and three within IL1RL1 (rs2310173, rs13015714 and rs2058660), that also were previously associated with several inflammatory diseases, were genotyped in 380 Caucasian IgAV patients and 845 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when IL33 and IL1RL1 variants were analysed independently. Likewise, no statistically significant differences were found in IL33 or IL1RL1 genotype and allele frequencies when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when IL33 and IL1RL1 haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that the IL33-IL1RL1 signalling pathway does not contribute to the genetic network underlying IgAV., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
8. Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.
- Author
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Papantoniou K, Castaño-Vinyals G, Espinosa A, Turner MC, Martín-Sánchez V, Casabonne D, Aragonés N, Gómez-Acebo I, Ardanaz E, Jimenez-Moleon JJ, Amiano P, Molina-Barceló A, Alguacil J, Fernández-Tardón G, Huerta JM, Hernández-Segura N, Perez-Gomez B, Llorca J, Vidán-Alli J, Olmedo-Requena R, Gil L, Castañon-López C, Pollan M, Kogevinas M, and Moreno V
- Subjects
- Aged, Body Mass Index, Case-Control Studies, Female, Humans, Male, Middle Aged, Multivariate Analysis, Spain, Colorectal Neoplasms physiopathology, Sleep physiology, Stomach Neoplasms physiopathology
- Abstract
Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR
≥9 hours : 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours : 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours : 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min : 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min : 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.- Published
- 2021
- Full Text
- View/download PDF
9. BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis.
- Author
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Prieto-Peña D, Genre F, Remuzgo-Martínez S, Pulito-Cueto V, Atienza-Mateo B, Llorca J, Sevilla-Pérez B, Ortego-Centeno N, Lera-Gómez L, Leonardo MT, Peñalba A, Narváez J, Martín-Penagos L, Rodrigo E, Miranda-Filloy JA, Caminal-Montero L, Collado P, Pérez JS, de Argila D, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Agirregoikoa E, Gualillo O, Martín J, Castañeda S, Blanco R, González-Gay MA, and López-Mejías R
- Subjects
- Adult, B-Cell Activating Factor immunology, B-Cell Activation Factor Receptor immunology, Female, Humans, Male, Tumor Necrosis Factor Ligand Superfamily Member 13 immunology, Autoimmune Diseases genetics, Autoimmune Diseases immunology, B-Cell Activating Factor genetics, B-Cell Activation Factor Receptor genetics, Immunoglobulin A immunology, Polymorphism, Single Nucleotide, Tumor Necrosis Factor Ligand Superfamily Member 13 genetics, Vasculitis genetics, Vasculitis immunology
- Abstract
BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV.
- Published
- 2021
- Full Text
- View/download PDF
10. Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study.
- Author
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Gómez-Acebo I, Dierssen-Sotos T, Mirones M, Pérez-Gómez B, Guevara M, Amiano P, Sala M, Molina AJ, Alonso-Molero J, Moreno V, Suarez-Calleja C, Molina-Barceló A, Alguacil J, Marcos-Gragera R, Fernández-Ortiz M, Sanz-Guadarrama O, Castaño-Vinyals G, Gil-Majuelo L, Moreno-Iribas C, Aragonés N, Kogevinas M, Pollán M, and Llorca J
- Subjects
- Adult, Aged, Breast Neoplasms metabolism, Breast Neoplasms mortality, Disease-Free Survival, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Staging, Retrospective Studies, Spain epidemiology, Survival Rate, Breast Neoplasms drug therapy, Chemotherapy, Adjuvant, Models, Biological
- Abstract
The St Gallen Conference endorsed in 2013 a series of recommendations on early breast cancer treatment. The main purpose of this article is to ascertain the clinical factors associated with St Gallen-2013 recommendations accomplishment. A cohort of 1152 breast cancer cases diagnosed with pathological stage < 3 in Spain between 2008 and 2013 was begun and then followed-up until 2017/2018. Data on patient and tumour characteristics were obtained from medical records, as well as their first line treatment. First line treatments were classified in three categories, according on whether they included the main St Gallen-2013 recommendations, more than those recommended or less than those recommended. Multinomial logistic regression models were carried out to identify factors associated with this classification and Weibull regression models were used to find out the relationship between this classification and survival. About half of the patients were treated according to St Gallen recommendations; 21% were treated over what was recommended and 33% received less treatment than recommended. Factors associated with treatment over the recommendations were stage II (relative risk ratio [RRR] = 4.2, 2.9-5.9), cancer positive to either progesterone (RRR = 8.1, 4.4-14.9) or oestrogen receptors (RRR = 5.7, 3.0-11.0). Instead, factors associated with lower probability of treatment over the recommendations were age (RRR = 0.7 each 10 years, 0.6-0.8), poor differentiation (RRR = 0.09, 0.04-0.19), HER2 positive (RRR = 0.46, 0.26-0.81) and triple negative cancer (RRR = 0.03, 0.01-0.11). Patients treated less than what was recommended in St Gallen had cancers in stage 0 (RRR = 21.6, 7.2-64.5), poorly differentiated (RRR = 1.9, 1.2-2.9), HER2 positive (RRR = 3.4, 2.4-4.9) and luminal B-like subtype (RRR = 3.6, 2.6-5.1). Women over 65 years old had a higher probability of being treated less than what was recommended if they had luminal B-like, HER2 or triple negative cancer. Treatment over St Gallen was associated with younger women and less severe cancers, while treatment under St Gallen was associated with older women, more severe cancers and cancers expressing HER2 receptors.
- Published
- 2021
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- View/download PDF
11. Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis.
- Author
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Genre F, Rueda-Gotor J, Remuzgo-Martínez S, Pulito-Cueto V, Corrales A, Mijares V, Lera-Gómez L, Portilla V, Expósito R, Mata C, Blanco R, Llorca J, Hernández-Hernández V, Vicente E, Fernández-Carballido C, Martínez-Vidal MP, Castro-Corredor D, Anino-Fernández J, Rodríguez-Lozano C, Gualillo O, Quevedo-Abeledo JC, Castañeda S, Ferraz-Amaro I, López-Mejías R, and González-Gay MÁ
- Subjects
- Adult, Biomarkers blood, Cardiovascular Diseases etiology, Cardiovascular Diseases genetics, Case-Control Studies, Cytokines genetics, Female, GPI-Linked Proteins blood, GPI-Linked Proteins genetics, Humans, Lectins genetics, Linkage Disequilibrium genetics, Male, Middle Aged, Polymorphism, Single Nucleotide genetics, Risk Factors, Spondylarthritis genetics, Cardiovascular Diseases blood, Cytokines blood, Lectins blood, Spondylarthritis blood
- Abstract
Cardiovascular (CV) disease is the main cause of mortality in axial spondyloarthritis (axSpA). CV risk is enhanced by dysregulation of adipokines. Low omentin levels were associated with metabolic dysfunction and CV disease in conditions different from axSpA. Accordingly, we evaluated the genetic and functional implication of omentin in CV risk and subclinical atherosclerosis in a cohort of 385 axSpA patients. Subclinical atherosclerosis was evaluated by carotid ultrasound. Omentin rs12409609, in linkage disequilibrium with a polymorphism associated with CV risk, was genotyped in 385 patients and 84 controls. Serum omentin levels were also determined. omentin mRNA expression was assessed in a subgroup of individuals. Serum and mRNA omentin levels were lower in axSpA compared to controls. Low serum omentin levels were related to male sex, obesity, inflammatory bowel disease (IBD) and high atherogenic index. rs12409609 minor allele was associated with low omentin mRNA expression in axSpA. No association was observed with subclinical atherosclerosis at the genetic or functional level. In conclusion, in our study low omentin serum levels were associated with CV risk factors in axSpA. Furthermore, rs12409609 minor allele may be downregulating the expression of omentin. These data support a role of omentin as a CV risk biomarker in axSpA.
- Published
- 2020
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12. Author Correction: Validating a breast cancer score in Spanish women. The MCC-Spain study.
- Author
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Dierssen-Sotos T, Gómez-Acebo I, Palazuelos C, Fernández-Navarro P, Altzibar JM, González-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tardón A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Castaño-Vinyals G, Ederra M, Vilorio-Marqués L, Amiano P, Pérez-Gómez B, Aragonés N, Kogevinas M, Pollán M, and Llorca J
- Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2020
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- View/download PDF
13. Influence of MUC5B gene on antisynthetase syndrome.
- Author
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López-Mejías R, Remuzgo-Martínez S, Genre F, Pulito-Cueto V, Rozas SMF, Llorca J, Fernández DI, Cuesta VMM, Ortego-Centeno N, Gómez NP, Mera-Varela A, Martínez-Barrio J, López-Longo FJ, Mijares V, Lera-Gómez L, Usetti MP, Laporta R, Pérez V, Gafas AP, González MAA, Calvo-Alén J, Romero-Bueno F, Sanchez-Pernaute O, Nuno L, Bonilla G, Balsa A, Hernández-González F, Grafia I, Prieto-González S, Narvaez J, Trallero-Araguas E, Selva-O'Callaghan A, Gualillo O, Castañeda S, Cavagna L, Cifrian JM, and González-Gay MA
- Subjects
- Adult, Female, Follow-Up Studies, Humans, Incidence, Lung Diseases, Interstitial epidemiology, Male, Middle Aged, Myositis complications, Polymorphism, Single Nucleotide, Promoter Regions, Genetic genetics, Lung Diseases, Interstitial genetics, Mucin-5B genetics, Myositis genetics
- Abstract
MUC5B rs35705950 (G/T) is strongly associated with idiopathic pulmonary fibrosis (IPF) and also contributes to the risk of interstitial lung disease (ILD) in rheumatoid arthritis (RA-ILD) and chronic hypersensitivity pneumonitis (CHP). Due to this, we evaluated the implication of MUC5B rs35705950 in antisynthetase syndrome (ASSD), a pathology characterised by a high ILD incidence. 160 patients with ASSD (142 with ILD associated with ASSD [ASSD-ILD+]), 232 with ILD unrelated to ASSD (comprising 161 IPF, 27 RA-ILD and 44 CHP) and 534 healthy controls were genotyped. MUC5B rs35705950 frequency did not significantly differ between ASSD-ILD+ patients and healthy controls nor when ASSD patients were stratified according to the presence/absence of anti Jo-1 antibodies or ILD. No significant differences in MUC5B rs35705950 were also observed in ASSD-ILD+ patients with a usual interstitial pneumonia (UIP) pattern when compared to those with a non-UIP pattern. However, a statistically significant decrease of MUC5B rs35705950 GT, TT and T frequencies in ASSD-ILD+ patients compared to patients with ILD unrelated to ASSD was observed. In summary, our study does not support a role of MUC5B rs35705950 in ASSD. It also indicates that there are genetic differences between ILD associated with and that unrelated to ASSD.
- Published
- 2020
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14. Hollow PdAg-CeO 2 heterodimer nanocrystals as highly structured heterogeneous catalysts.
- Author
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Patarroyo J, Delgado JA, Merkoçi F, Genç A, Sauthier G, Llorca J, Arbiol J, Bastus NG, Godard C, Claver C, and Puntes V
- Abstract
In the present work, hollow PdAg-CeO
2 heterodimer nanocrystals (NCs) were prepared and tested as catalysts for the selective hydrogenation of alkynes. These nanostructures combine for the first time the beneficial effect of alloying Pd with Ag in a single NC hollow domain with the formation of active sites at the interface with the CeO2 counterpart in an additive manner. The PdAg-CeO2 NCs display excellent alkene selectivity for aliphatic alkynes. For the specific case of hydrogenation of internal alkynes such as 4-octyne, very low over-hydrogenation and isomerization products were observed over a full conversion regime, even after prolonged reaction times. These catalytic properties were remarkably superior in comparison to standard catalysts. The promotion of Ag on the moderation of the reactivity of the Pd phase, in combination with the creation of interfacial sites with the CeO2 moiety in the same nanostructure, is pointed as the responsible of such a remarkable catalytic performance.- Published
- 2019
- Full Text
- View/download PDF
15. Mendelian randomization analysis rules out disylipidaemia as colorectal cancer cause.
- Author
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Ibáñez-Sanz G, Díez-Villanueva A, Riera-Ponsati M, Fernández-Villa T, Fernández Navarro P, Bustamante M, Llorca J, Amiano P, Ascunce N, Fernández-Tardón G, Salcedo Bellido I, Salas D, Capelo Álvarez R, Crous-Bou M, Ortega-Valín L, Pérez-Gómez B, Castaño-Vinyals G, Palazuelos C, Altzibar JM, Ardanaz E, Tardón A, Jiménez Moleón JJ, Olmos Juste V, Aragonés N, Pollán M, Kogevinas M, and Moreno V
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Incidence, Male, Middle Aged, Prognosis, Risk Factors, Spain epidemiology, Young Adult, Colorectal Neoplasms epidemiology, Dyslipidemias physiopathology, Lipids analysis, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide
- Abstract
Dyslipidemia and statin use have been associated with colorectal cancer (CRC), but prospective studies have shown mixed results. We aimed to determine whether dyslipidemia is causally linked to CRC risk using a Mendelian randomization approach and to explore the association of statins with CRC. A case-control study was performed including 1336 CRC cases and 2744 controls (MCC-Spain). Subjects were administered an epidemiological questionnaire and were genotyped with an array which included polymorphisms associated with blood lipids levels, selected to avoid pleiotropy. Four genetic lipid scores specific for triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), or total cholesterol (TC) were created as the count of risk alleles. The genetic lipid scores were not associated with CRC. The ORs per 10 risk alleles, were for TG 0.91 (95%CI: 0.72-1.16, p = 0.44), for HDL 1.14 (95%CI: 0.95-1.37, p = 0.16), for LDL 0.97 (95%CI: 0.81-1.16, p = 0.73), and for TC 0.98 (95%CI: 0.84-1.17, p = 0.88). The LDL and TC genetic risk scores were associated with statin use, but not the HDL or TG. Statin use, overall, was a non-significant protective factor for CRC (OR 0.84; 95%CI: 0.70-1.01, p = 0.060), but lipophilic statins were associated with a CRC risk reduction (OR 0.78; 95%CI 0.66-0.96, p = 0.018). Using the Mendelian randomization approach, our study does not support the hypothesis that lipid levels are associated with the risk of CRC. This study does not rule out, however, a possible protective effect of statins in CRC by a mechanism unrelated to lipid levels.
- Published
- 2019
- Full Text
- View/download PDF
16. A join point regression analysis of trends in mortality due to osteoporosis in Spain.
- Author
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Dragomirescu I, Llorca J, Gómez-Acebo I, and Dierssen-Sotos T
- Subjects
- Age Distribution, Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Osteoporosis complications, Osteoporotic Fractures etiology, Regression Analysis, Sex Distribution, Sex Factors, Spain epidemiology, Mortality trends, Osteoporosis mortality, Osteoporotic Fractures mortality
- Abstract
Osteoporosis is a major health problem in terms of fracture probability and disability. The aim of this ecological study is to identify the temporal trends in osteoporosis mortality in Spain from 1999 to 2015. Data on the Spanish population and number of deaths due to osteoporosis were obtained from the Spanish National Institute for Statistics. Age-adjusted mortality rates were estimated. Join point regression was used to identify the years when changes in mortality s and annual percentage change in mortality rates took place. Women presented a greater mortality rate decrease (p < 0.001), though this mortality difference by sex was reduced by half at the end of the period. The higher the age, the faster the mortality rate declined in women, while no clear pattern could be identified in men. In women, significant changes in trends were identified in three age groups (50-54, 60-64 and 80-84 years old). A sustained decrease in osteoporosis-associated mortality was found in women aged 75-79 and ≥85 years and men aged 60-64. In conclusion, mortality caused by osteoporosis in Spain is decreasing faster in the older age ranges especially in women.
- Published
- 2019
- Full Text
- View/download PDF
17. Association of circulating calprotectin with lipid profile in axial spondyloarthritis.
- Author
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Genre F, Rueda-Gotor J, Remuzgo-Martínez S, Corrales A, Mijares V, Expósito R, Mata C, Portilla V, Blanco R, Hernández JL, Llorca J, Gualillo O, López-Mejías R, and González-Gay MA
- Subjects
- Adult, Atherosclerosis pathology, Biomarkers blood, C-Reactive Protein metabolism, Carotid Arteries pathology, Carotid Intima-Media Thickness, Cholesterol, HDL blood, Female, Humans, Inflammation pathology, Male, Middle Aged, Spondylarthritis pathology, Ultrasonography, Atherosclerosis blood, Inflammation blood, Leukocyte L1 Antigen Complex blood, Lipids blood, Spondylarthritis blood
- Abstract
Calprotectin (CPT) is released during inflammation, also in the context of atherosclerosis. The link between CPT and the atherosclerotic process was evaluated in several diseases. However, studies in axial spondyloarthritis (axSpA), associated with a high incidence of subclinical atherosclerosis, are scarce. Therefore, we assessed the association of CPT with subclinical atherosclerosis and metabolic risk factors in axSpA. CPT serum levels were measured by enzyme-linked immunosorbent assay in 163 axSpA patients and 63 controls. Subclinical atherosclerosis was determined in patients by carotid ultrasonography (assessing the presence/absence of carotid plaques and carotid intima-media thickness [cIMT]). Data on inflammation, disease activity, lipid profile and treatment were collected to evaluate its relationship with CPT. axSpA patients evidenced lower CPT levels than controls. CPT showed no association with plaques or cIMT in axSpA. CPT and HDL-cholesterol negatively correlated, while a positive association of CPT with the atherogenic index was disclosed. Additionally, axSpA patients with C-reactive protein values at diagnosis higher than 3 mg/L displayed higher CPT levels. Our study shows no relationship between CPT and markers of subclinical atherosclerosis in axSpA. Nevertheless, it demonstrates an association of CPT with adverse lipid profiles and inflammatory biomarkers, which could further influence on the development of atherosclerosis.
- Published
- 2018
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18. Vitamin D exposure and Risk of Breast Cancer: a meta-analysis.
- Author
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Estébanez N, Gómez-Acebo I, Palazuelos C, Llorca J, and Dierssen-Sotos T
- Subjects
- Breast Neoplasms prevention & control, Case-Control Studies, Female, Humans, Odds Ratio, Premenopause, Protective Agents administration & dosage, Risk Factors, Vitamins administration & dosage, Breast Neoplasms pathology, Calcifediol administration & dosage, Calcitriol administration & dosage, Vitamin D administration & dosage
- Abstract
The relationship between vitamin D and breast cancer is still controversial. The present meta-analysis examines the effects of the 25(OH)D, 1,25(OH)2D and vitamin D intake on breast cancer risk. For this purpose, a PubMed, Scopus and Web of Science-databases search was conducted including all papers published with the keywords "breast cancer" and "vitamin D" with at least one reported relative risk (RR) or odds ratio (OR). In total sixty eight studies published between 1998 and 2018 were analyzed. Information about type of study, hormonal receptors and menopausal status was retrieved. Pooled OR or RR were estimated by weighting individual OR/RR by the inverse of their variance Our study showed a protective effect between 25 (OH) D and breast cancer in both cohort studies (RR = 0.85, 95%CI:0.74-0.98) and case-control studies (OR = 0.65, 95%CI: 0.56-0.76). However, analyzing by menopausal status, the protective vitamin D - breast cancer association persisted only in the premenopausal group (OR = 0.67, 95%CI: 0.49-0.92) when restricting the analysis to nested case-control studies. No significant association was found for vitamin D intake or 1,25(OH)2D., Conclusion: This systematic review suggests a protective relationship between circulating vitamin D (measured as 25(OH) D) and breast cancer development in premenopausal women.
- Published
- 2018
- Full Text
- View/download PDF
19. Validating a breast cancer score in Spanish women. The MCC-Spain study.
- Author
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Dierssen-Sotos T, Gómez-Acebo I, Palazuelos C, Fernández-Navarro P, Altzibar JM, González-Donquiles C, Ardanaz E, Bustamante M, Alonso-Molero J, Vidal C, Bayo-Calero J, Tardón A, Salas D, Marcos-Gragera R, Moreno V, Rodriguez-Cundin P, Castaño-Vinyals G, Ederra M, Vilorio-Marqués L, Amiano P, Pérez-Gómez B, Aragonés N, Kogevinas M, Pollán M, and Llorca J
- Subjects
- Area Under Curve, Breast Neoplasms genetics, Case-Control Studies, Female, Genetic Predisposition to Disease genetics, Genetic Testing methods, Humans, Logistic Models, Models, Statistical, Polymorphism, Single Nucleotide genetics, ROC Curve, Reproducibility of Results, Risk Factors, Spain epidemiology, White People genetics, Breast Neoplasms epidemiology, Mass Screening methods, Risk Assessment methods
- Abstract
A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores. Score performances were tested via the area under the ROC curve (AUROC), net reclassification index (NRI) and integrated discrimination improvement (IDI). Compared with non-modifiable and modifiable factor scores, GRS92 had higher discrimination power (AUROC: 0.6195, 0.5885 and 0.5214, respectively). Adding the non-modifiable factor score to GRS92 improved patient classification by 23.6% (NRI = 0.236), while the modifiable factor score only improved it by 7.2%. The full model AUROC reached 0.6244. A simulation study showed the ability of the full model for identifying women at high risk for breast cancer. In conclusion, a model combining genetic and risk factors can be used for stratifying women by their breast cancer risk, which can be applied to individualizing genetic counseling and screening recommendations.
- Published
- 2018
- Full Text
- View/download PDF
20. Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study.
- Author
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Ibáñez-Sanz G, Díez-Villanueva A, Vilorio-Marqués L, Gracia E, Aragonés N, Olmedo-Requena R, Llorca J, Vidán J, Amiano P, Nos P, Fernández-Tardón G, Rada R, Chirlaque MD, Guinó E, Dávila-Batista V, Castaño-Vinyals G, Pérez-Gómez B, Mirón-Pozo B, Dierssen-Sotos T, Etxeberria J, Molinuevo A, Álvarez-Cuenllas B, Kogevinas M, Pollán M, and Moreno V
- Subjects
- Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Case-Control Studies, Colorectal Neoplasms prevention & control, Dietary Supplements, Female, Humans, Male, Middle Aged, Chondroitin Sulfates administration & dosage, Colorectal Neoplasms epidemiology, Glucosamine administration & dosage
- Abstract
A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28-0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47-1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62-0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs.
- Published
- 2018
- Full Text
- View/download PDF
21. Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis.
- Author
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Remuzgo-Martínez S, Genre F, Castañeda S, Corrales A, Moreno-Fresneda P, Ubilla B, Mijares V, Portilla V, González-Vela J, Pina T, Ocejo-Vinyals G, Irure-Ventura J, Blanco R, Martín J, Llorca J, López-Mejías R, and González-Gay MA
- Subjects
- Adult, Aged, Arthritis, Rheumatoid genetics, Biomarkers blood, CSK Tyrosine-Protein Kinase, Case-Control Studies, Female, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatase, Non-Receptor Type 22 genetics, src-Family Kinases genetics, Arthritis, Rheumatoid blood, Down-Regulation, Protein Tyrosine Phosphatase, Non-Receptor Type 22 blood, src-Family Kinases blood
- Abstract
Several protein tyrosine phosphatase non-receptor 22 (PTPN22) single-nucleotide polymorphisms (SNPs) have been significantly related with rheumatoid arthritis (RA) susceptibility. Nevertheless, its potential influence on PTPN22 expression in RA has not been completely elucidated. Furthermore, PTPN22 binds to C-Src tyrosine kinase (CSK) forming a key complex in autoimmunity. However, the information of CSK gene in RA is scarce. In this study, we analyzed the relative PTPN22 and CSK expression in peripheral blood from 89 RA patients and 43 controls to determine if the most relevant PTPN22 (rs2488457, rs2476601 and rs33996649) and CSK (rs34933034 and rs1378942) polymorphisms may influence on PTPN22 and CSK expression in RA. The association between PTPN22 and CSK expression in RA patients and their clinical characteristics was also evaluated. Our study shows for the first time a marked down-regulation of PTPN22 expression in RA patients carrying the risk alleles of PTPN22 rs2488457 and rs2476601 compared to controls (p = 0.004 and p = 0.007, respectively). Furthermore, CSK expression was significantly lower in RA patients than in controls (p < 0.0001). Interestingly, a reduced PTPN22 expression was disclosed in RA patients with ischemic heart disease (p = 0.009). The transcriptional suppression of this PTPN22/CSK complex may have a noteworthy clinical relevance in RA patients.
- Published
- 2017
- Full Text
- View/download PDF
22. Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study.
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Gómez-Acebo I, Dierssen-Sotos T, Fernandez-Navarro P, Palazuelos C, Moreno V, Aragonés N, Castaño-Vinyals G, Jiménez-Monleón JJ, Ruiz-Cerdá JL, Pérez-Gómez B, Ruiz-Dominguez JM, Molero JA, Pollán M, Kogevinas M, and Llorca J
- Subjects
- Adult, Aged, Aged, 80 and over, Genotype, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, ROC Curve, Risk Factors, Spain epidemiology, Young Adult, Environmental Exposure, Genetic Predisposition to Disease, Models, Statistical, Prostatic Neoplasms epidemiology
- Abstract
Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model.
- Published
- 2017
- Full Text
- View/download PDF
23. A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis.
- Author
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López-Mejías R, Carmona FD, Castañeda S, Genre F, Remuzgo-Martínez S, Sevilla-Perez B, Ortego-Centeno N, Llorca J, Ubilla B, Mijares V, Pina T, Miranda-Filloy JA, Navas Parejo A, de Argila D, Aragües M, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, Jayne D, Blanco R, Martín J, and González-Gay MA
- Subjects
- Humans, Logistic Models, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Histocompatibility Antigens Class II genetics, Immunoglobulin A immunology, Vasculitis genetics, Vasculitis immunology
- Abstract
The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on the genetic component of this vasculitis we performed the first genome-wide association study (GWAS) on this condition. 308 IgA vasculitis patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation of GWAS data was performed using the 1000 Genomes Project Phase III dataset as reference panel. After quality control filters and GWAS imputation, 285 patients and 1,006 controls remained in the datasets and were included in further analysis. Additionally, the human leukocyte antigen (HLA) region was comprehensively studied by imputing classical alleles and polymorphic amino acid positions. A linkage disequilibrium block of polymorphisms located in the HLA class II region surpassed the genome-wide level of significance (OR = 0.56, 95% CI = 0.46-0.68). Although no polymorphic amino acid positions were associated at the genome-wide level of significance, P-values of potential relevance were observed for the positions 13 and 11 of HLA-DRB1 (P = 6.67E-05, P = 1.88E-05, respectively). Outside the HLA, potential associations were detected, but none of them were close to the statistical significance. In conclusion, our study suggests that IgA vasculitis is an archetypal HLA class II disease.
- Published
- 2017
- Full Text
- View/download PDF
24. Corrigendum: Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study.
- Author
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Ibáñez-Sanz G, Díez-Villanueva A, Alonso MH, Rodríguez-Moranta F, Pérez-Gómez B, Bustamante M, Martin V, Llorca J, Amiano P, Ardanaz E, Tardón A, Jiménez-Moleón JJ, Peiró R, Alguacil J, Navarro C, Guinó E, Binefa G, Fernández-Navarro P, Espinosa A, Dávila-Batista V, Molina AJ, Palazuelos C, Castaño-Vinyals G, Aragonés N, Kogevinas M, Pollán M, and Moreno V
- Published
- 2017
- Full Text
- View/download PDF
25. Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study.
- Author
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Ibáñez-Sanz G, Díez-Villanueva A, Alonso MH, Rodríguez-Moranta F, Pérez-Gómez B, Bustamante M, Martin V, Llorca J, Amiano P, Ardanaz E, Tardón A, Jiménez-Moleón JJ, Peiró R, Alguacil J, Navarro C, Guinó E, Binefa G, Fernández-Navarro P, Espinosa A, Dávila-Batista V, Molina AJ, Palazuelos C, Castaño-Vinyals G, Aragonés N, Kogevinas M, Pollán M, and Moreno V
- Subjects
- Case-Control Studies, Gene Frequency, Humans, Models, Statistical, Polymorphism, Single Nucleotide, Risk Assessment, Spain epidemiology, Colorectal Neoplasms epidemiology, Colorectal Neoplasms genetics, Environmental Exposure
- Abstract
Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5
th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.- Published
- 2017
- Full Text
- View/download PDF
26. Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis.
- Author
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López-Mejías R, Corrales A, Vicente E, Robustillo-Villarino M, González-Juanatey C, Llorca J, Genre F, Remuzgo-Martínez S, Dierssen-Sotos T, Miranda-Filloy JA, Huaranga MA, Pina T, Blanco R, Alegre-Sancho JJ, Raya E, Mijares V, Ubilla B, Ferraz-Amaro I, Gómez-Vaquero C, Balsa A, López-Longo FJ, Carreira P, González-Álvaro I, Ocejo-Vinyals JG, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Castañeda S, Martín J, and González-Gay MA
- Subjects
- Female, Humans, Male, Middle Aged, Risk Factors, Spain, Arthritis, Rheumatoid genetics, Atherosclerosis complications, Atherosclerosis genetics, Coronary Artery Disease complications, Coronary Artery Disease genetics, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide genetics
- Abstract
A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.
- Published
- 2017
- Full Text
- View/download PDF
27. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.
- Author
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López-Mejías R, Genre F, Remuzgo-Martínez S, González-Juanatey C, Robustillo-Villarino M, Llorca J, Corrales A, Vicente E, Miranda-Filloy JA, Magro C, Tejera-Segura B, Ramírez Huaranga MA, Pina T, Blanco R, Alegre-Sancho JJ, Raya E, Mijares V, Ubilla B, Mínguez Sánchez MD, Gómez-Vaquero C, Balsa A, Pascual-Salcedo D, López-Longo FJ, Carreira P, González-Álvaro I, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Ferraz-Amaro I, Castañeda S, Martín J, and González-Gay MA
- Subjects
- Aged, Arthritis, Rheumatoid epidemiology, Atherosclerosis diagnostic imaging, Atherosclerosis epidemiology, Cardiovascular Diseases diagnostic imaging, Cardiovascular Diseases epidemiology, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, White People, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid genetics, Atherosclerosis blood, Atherosclerosis genetics, C-Reactive Protein genetics, Cardiovascular Diseases blood, Cardiovascular Diseases genetics
- Abstract
Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.
- Published
- 2016
- Full Text
- View/download PDF
28. Expression of osteoprotegerin and its ligands, RANKL and TRAIL, in rheumatoid arthritis.
- Author
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Remuzgo-Martínez S, Genre F, López-Mejías R, Ubilla B, Mijares V, Pina T, Corrales A, Blanco R, Martín J, Llorca J, and González-Gay MA
- Subjects
- Antirheumatic Agents administration & dosage, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid pathology, Female, Humans, Male, Myocardial Ischemia blood, Myocardial Ischemia drug therapy, Myocardial Ischemia pathology, Arthritis, Rheumatoid blood, Gene Expression Regulation, Osteoprotegerin blood, RANK Ligand blood, TNF-Related Apoptosis-Inducing Ligand blood
- Abstract
Osteoprotegerin (OPG), receptor activator of nuclear factor-ΚB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) have been involved in rheumatoid arthritis (RA) pathophysiology. In this study, we assessed messenger RNA (mRNA) expression of these molecules by qPCR in peripheral blood from 26 patients with RA (12 of them with ischemic heart disease -IHD) and 10 healthy controls. Correlation coefficients between OPG, RANKL and TRAIL expression levels in RA patients and their clinical and demographic characteristics were also evaluated. Whereas OPG and OPG/TRAIL ratio expression were significantly increased in RA patients compared to controls (fold change = 1.79, p = 0.013 and 2.07, p = 0.030, respectively), RANKL/OPG ratio was significantly decreased (fold change = 0.50, p = 0.020). No significant differences were found between patients and controls in RANKL and TRAIL expression. Interestingly, TRAIL expression was significantly higher in RA patients with IHD compared to those without IHD (fold change = 1.46, p = 0.033). Moreover, biologic disease-modifying antirheumatic drugs (DMARDs) significantly decreased RANKL expression in RA patients (p = 0.016). Our study supports an important role of OPG and TRAIL in RA. Furthermore, it highlights an effect of biologic DMARDs in the modulation of RANKL.
- Published
- 2016
- Full Text
- View/download PDF
29. Macroscopic CNT fibres inducing non-epitaxial nucleation and orientation of semicrystalline polymers.
- Author
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Yue H, Monreal-Bernal A, Fernández-Blázquez JP, Llorca J, and Vilatela JJ
- Abstract
In the presence of macroscopic fibres of carbon nanotubes (CNT), various semicrystalline polymers are shown to present accelerated crystallisation through the formation of a transcrystalline (TC) layer perpendicular to the fibre axis. From differential scanning calorimetry, polarized optical microscopy and X-ray diffraction we establish this to be due to much faster nucleation rates at the fibre surface. The formation of a TC layers is demonstrated for polyvinyldene fluoride, isotactic polypropylene and poly(lactic acid) in spite of the large differences in their chemistry and structure unit cells, suggesting that epitaxy in terms of lattice type or size matching is not a prerequisite. For the three polymers as well as poly(ether ether ketone), the TC layer is identically oriented with the chain axis in the lamella parallel to the CNTs, as observed by wide and small angle X-ray scattering. These results point to polymer chain orientation at the point of adsorption and the formation of a mesomorphic layer as possible steps in the fast nucleation of oriented lamella, with wetting of the CNT fibre surface by the molten semi-crystalline polymer a key condition for heterogeneous nucleation to take place.
- Published
- 2015
- Full Text
- View/download PDF
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