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Start Over Author "Li, Weiqin" Journal scientific reports
12 results on '"Li, Weiqin"'

3. Corrigendum: Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis

Author

Wang, Yunan, Kayoumu, Abudurexiti, Lu, Guotao, Xu, Pengfei, Qiu, Xu, Chen, Liye, Qi, Rong, Huang, Shouxiong, Li, Weiqin, Wang, Yuhui, and Liu, George

Subjects
Taurocholic Acid, Ethanol, Mesocricetus, Fatty Acids, Arginine, Corrigenda, Severity of Illness Index, Article, Injections, Disease Models, Animal, Pancreatitis, Amylases, Animals, Humans, Ceruletide, Peroxidase
Abstract

The hamster has been shown to share a variety of metabolic similarities with humans. To replicate human acute pancreatitis with hamsters, we comparatively studied the efficacy of common methods, such as the peritoneal injections of caerulein, L-arginine, the retrograde infusion of sodium taurocholate, and another novel model with concomitant administration of ethanol and fatty acid. The severity of pancreatitis was evaluated by serum amylase activity, pathological scores, myeloperoxidase activity, and the expression of inflammation factors in pancreas. The results support that the severity of pathological injury is consistent with the pancreatitis induced in mice and rat using the same methods. Specifically, caerulein induced mild edematous pancreatitis accompanied by minimal lung injury, while L-arginine induced extremely severe pancreatic injury including necrosis and neutrophil infiltration. Infusion of Na-taurocholate into the pancreatic duct induced necrotizing pancreatitis in the head of pancreas and lighter inflammation in the distal region. The severity of acute pancreatitis induced by combination of ethanol and fatty acids was between the extent of caerulein and L-arginine induction, with obvious inflammatory cells infiltration. In view of the advantages in lipid metabolism features, hamster models are ideally suited for the studies of pancreatitis associated with altered metabolism in humans.

Published
2016

4. The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis

Author

de Carvalho, Aline Martins, primary, Shao, Ping, additional, Liu, Huikun, additional, Cheng, Han-Ling, additional, Zheng, Yan, additional, Leng, Junhong, additional, Li, Weiqin, additional, Huang, Tao, additional, Wang, Tiange, additional, Wang, Leishen, additional, Zhang, Shuang, additional, Hu, Gang, additional, and Qi, Lu, additional

Published
2017
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7. Physical Activity, TV Watching Time, Sleeping, and Risk of Obesity and Hyperglycemia in the Offspring of Mothers with Gestational Diabetes Mellitus

Author

Zhang, Tao, primary, Wang, Peng, additional, Liu, Huikun, additional, Wang, Leishen, additional, Li, Weiqin, additional, Leng, Junhong, additional, Li, Nan, additional, Zhang, Shuang, additional, Qi, Lu, additional, Tuomilehto, Jaakko, additional, Yu, Zhijie, additional, Yang, Xilin, additional, and Hu, Gang, additional

Published
2017
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8. Development of a novel model of hypertriglyceridemic acute pancreatitis in mice

Author

Pan, Yiyuan, primary, Li, Yong, additional, Gao, Lin, additional, Tong, Zhihui, additional, Ye, Bo, additional, Liu, Shufeng, additional, Li, Baiqiang, additional, Chen, Yizhe, additional, Yang, Qi, additional, Meng, Lei, additional, Wang, Yuhui, additional, Liu, George, additional, Lu, Guotao, additional, Li, Weiqin, additional, and Li, Jieshou, additional

Published
2017
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9. Hypothalamic activation is essential for endotoxemia-induced acute muscle wasting

Author

Duan, Kaipeng, primary, Chen, Qiyi, additional, Cheng, Minhua, additional, Zhao, Chenyan, additional, Lin, Zhiliang, additional, Tan, Shanjun, additional, Xi, Fengchan, additional, Gao, Tao, additional, Shi, Jialiang, additional, Shen, Juanhong, additional, Li, Weiqin, additional, Yu, Wenkui, additional, Li, Jieshou, additional, and Li, Ning, additional

Published
2016
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