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7. A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells.

Author

Zhang, Saiyang, Li, Tingyu, Zhang, Li, Wang, Xiangyu, Dong, Hangqi, Li, Lili, Fu, Dongjun, Li, Yongchun, Zi, Xiaolin, Liu, Hong-Min, Zhang, Yanbing, Xu, Hongde, and Jin, Cheng-Yun

Subjects
Cell Line, Tumor, Mitochondria, Animals, Humans, Mice, Stomach Neoplasms, Disease Models, Animal, Reactive Oxygen Species, Chalcone, Caspases, Xenograft Model Antitumor Assays, Signal Transduction, Apoptosis, Cell Proliferation, Cell Survival, Receptors, TNF-Related Apoptosis-Inducing Ligand, Membrane Potential, Mitochondrial, Biomarkers, Cell Line, Tumor, Disease Models, Animal, Membrane Potential, Mitochondrial, Receptors, TNF-Related Apoptosis-Inducing Ligand
Abstract

A new series of etherification chalcone derivatives were designed and synthesized through Willimison etherification and Claisen-Schmidt condensation. Among them, compound 2-c which was given chemical name of S17, has been successfully screened out as the most potent one on gastric cancer cell line(MGC803) through the investigation for their effects against the growth of five cancer cell lines (EC109, HepG2, MCF7, MGC803, SKNSH). S17 exhibited strong anti-proliferative activity on other two gastric cancer cells (HGC27 and SGC7901), but less cytotoxicity to non-malignant gastric epithelial cells GES1. S17 potently killed gastric cancer cells with causing modulation of Bcl-2 family proteins and activation of caspase 9/3 cascade. S17 also up-regulated DR5 expression and DR5 knockdown partially reversed S17-induced apoptosis, caspase activation and MMP decrease. S17 robustly induced generation of ROS with Keap/Nrf2 pathway activated and the application of ROS scavenger N-acetyl cysteine (NAC) completely blocked these effects by S17 in MGC803 cells. Intraperitoneal administration of S17 significantly inhibited the growth of MGC803 cells in vivo in a xenograft mouse model without observed toxicity. These results indicated that S17 is a leadbrominated chalcone derivate and deserves further investigation for prevention and treatment of gastric cancer.

Published
2017

18. Transcriptional insights into the pyramided resistance to rice bacterial blight

Author

Li Lili, Li Lun, Lihong Chen, Weixiong Zhang, Junfei Zhou, Fang Zhiwei, Lu Long, Wenxue Zhai, Lifen Gao, Tiantian Li, and Hai Peng

Subjects
0301 basic medicine, Xanthomonas, Science, Plant disease resistance, Biology, Article, Transcriptome, 03 medical and health sciences, Gene Expression Regulation, Plant, Gene expression, Blight, Gene, Genotyping, Disease Resistance, Plant Diseases, Genetics, Multidisciplinary, Gene Expression Profiling, food and beverages, Oryza, R gene, 030104 developmental biology, Genetic marker, Medicine
Abstract

The pyramiding of resistance (R) genes provides broad-spectrum and durable resistance to plant diseases. However, the genetic basis for bacterial blight (BB) resistance remains unclear. The BB R gene pyramided line IRBB54, which expresses xa5 and Xa21, possessed a higher level of resistance than both single R gene lines. Large-scale genotyping of genetic markers in this study revealed similar genetic backgrounds among the near-isogenic lines (NILs), suggesting that resistance in the resistant NILs was mainly conferred by the individual R genes or the interaction between them. Transcriptome analysis demonstrated that more than 50% of the differentially expressed genes (DEGs), and more than 70% of the differentially expressed functions, were shared between IRBB54 and IRBB5 or IRBB21. Most of the DEGs in the resistant NILs were downregulated and are predicted to function in cellular and biological process. The DEGs common among the resistant NILs mainly showed non-additive expression patterns and enrichment in stress-related pathways. The differential expression of agronomic trait-controlled genes in the resistant NILs, especially in IRBB54, indicated the existence of potential side-effects resulting from gene pyramiding. Our findings contribute to the understanding of R gene pyramiding, as well as its effects on targeted and non-targeted trait(s).

Published
2018

22. Expansion and stress responses of AP2/EREBP superfamily in Brachypodium Distachyon

Author

Guangxiao Yang, Jiapeng Han, Weixiong Zhang, Junfei Zhou, Guangyuan He, Li Lun, Lihong Chen, Li Lili, Hai Peng, Shenglong Tan, and Xiaomin Deng

Subjects
0301 basic medicine, Subfamily, DNA, Plant, Article, 03 medical and health sciences, Stress, Physiological, Gene family, Gene, Plant Proteins, Homeodomain Proteins, 2. Zero hunger, Genetics, Multidisciplinary, biology, Gene Expression Profiling, Intron, Nuclear Proteins, food and beverages, biology.organism_classification, Biological Evolution, DNA-Binding Proteins, Gene expression profiling, 030104 developmental biology, Brachypodium distachyon, Tandem exon duplication, Functional divergence, Brachypodium
Abstract

APETALA2/ethylene-responsive element binding protein (AP2/EREBP) transcription factors constitute one of the largest and most conserved gene families in plant and play essential roles in growth, development and stress response. Except a few members, the AP2/EREBP family has not been characterized in Brachypodium distachyon, a model plant of Poaceae. We performed a genome-wide study of this family in B. distachyon by phylogenetic analyses, transactivation assays and transcript profiling. A total of 149 AP2/EREBP genes were identified and divided into four subfamilies, i.e., ERF (ethylene responsive factor), DREB (dehydration responsive element binding gene), RAV (related to ABI3/VP) and AP2. Tandem duplication was a major force in expanding B. distachyon AP2/EREBP (BdAP2/EREBP) family. Despite a significant expansion, genomic organizations of BdAP2/EREBPs were monotonous as the majority of them, except those of AP2 subfamily, had no intron. An analysis of transcription activities of several closely related and duplicated BdDREB genes showed their functional divergence and redundancy in evolution. The expression of BdAP2/EREBPs in different tissues and the expression of DREB/ERF subfamilies in B. distachyon, wheat and rice under abiotic stresses were investigated by next-generation sequencing and microarray profiling. Our results are valuable for further function analysis of stress tolerant AP2/EREBP genes in B. distachyon.

Published
2016

24. Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation

Author

Li, Can, primary, Zhang, Jie, additional, Wu, Hao, additional, Li, Lili, additional, Yang, Caiting, additional, Song, Shushu, additional, Peng, Peike, additional, Shao, Miaomiao, additional, Zhang, Mingming, additional, Zhao, Junjie, additional, Zhao, Ran, additional, Wu, Weicheng, additional, Ruan, Yuanyuan, additional, Wang, Lan, additional, and Gu, Jianxin, additional

Published
2017
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25. Decreased expression of STING predicts poor prognosis in patients with gastric cancer

Author

Song, Shushu, primary, Peng, Peike, additional, Tang, Zhaoqing, additional, Zhao, Junjie, additional, Wu, Weicheng, additional, Li, Haojie, additional, Shao, Miaomiao, additional, Li, Lili, additional, Yang, Caiting, additional, Duan, Fangfang, additional, Zhang, Mingming, additional, Zhang, Jie, additional, Wu, Hao, additional, Li, Can, additional, Wang, Xuefei, additional, Wang, Hongshan, additional, Ruan, Yuanyuan, additional, and Gu, Jianxin, additional

Published
2017
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26. High expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer

Author

Yang, Caiting, primary, Peng, Peike, additional, Li, Lili, additional, Shao, Miaomiao, additional, Zhao, Junjie, additional, Wang, Lan, additional, Duan, Fangfang, additional, Song, Shushu, additional, Wu, Hao, additional, Zhang, Jie, additional, Zhao, Ran, additional, Jia, Dongwei, additional, Zhang, Mingming, additional, Wu, Weicheng, additional, Li, Can, additional, Rong, Yefei, additional, Zhang, Lei, additional, Ruan, Yuanyuan, additional, and Gu, Jianxin, additional

Published
2016
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27. High Hepsin expression predicts poor prognosis in Gastric Cancer

Author

Zhang, Mingming, primary, Zhao, Junjie, additional, Tang, Wenyi, additional, Wang, Yanru, additional, Peng, Peike, additional, Li, Lili, additional, Song, Shushu, additional, Wu, Hao, additional, Li, Can, additional, Yang, Caiting, additional, Wang, Xuefei, additional, Zhang, Chunyi, additional, and Gu, Jianxin, additional

Published
2016
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28. Rice Xa21 primed genes and pathways that are critical for combating bacterial blight infection

Author

Zhihui Xia, Wenxue Zhai, Junfei Zhou, Tiantian Li, Zheng Chen, Lifen Gao, Fang Zhiwei, Weixiong Zhang, Hai Peng, Li Lili, and Lihong Chen

Subjects
Cytokinins, Time Factors, Plant disease resistance, Protein Serine-Threonine Kinases, Oryza, Article, Transcriptome, Xanthomonas oryzae, Plant Growth Regulators, Gene Expression Regulation, Plant, Cluster Analysis, Gene, Disease Resistance, Plant Diseases, Plant Proteins, 2. Zero hunger, Genetics, Regulation of gene expression, Multidisciplinary, Oryza sativa, biology, Gene Expression Profiling, food and beverages, biology.organism_classification, Gene expression profiling, Phenotype, Signal Transduction
Abstract

Rice bacterial blight (BB) is a devastating rice disease. The Xa21 gene confers a broad and persistent resistance against BB. We introduced Xa21 into Oryza sativa L ssp indica (rice 9311), through multi-generation backcrossing and generated a nearly isogenic, blight-resistant 9311/Xa21 rice. Using next-generation sequencing, we profiled the transcriptomes of both varieties before and within four days after infection of bacterium Xanthomonas oryzae pv. oryzae. The identified differentially expressed (DE) genes and signaling pathways revealed insights into the functions of Xa21. Surprisingly, before infection 1,889 genes on 135 of the 316 signaling pathways were DE between the 9311/Xa21 and 9311 plants. These Xa21-mediated basal pathways included mainly those related to the basic material and energy metabolisms and many related to phytohormones such as cytokinin, suggesting that Xa21 triggered redistribution of energy, phytohormones and resources among essential cellular activities before invasion. Counter-intuitively, after infection, the DE genes between the two plants were only one third of that before the infection; other than a few stress-related pathways, the affected pathways after infection constituted a small subset of the Xa21-mediated basal pathways. These results suggested that Xa21 primed critically important genes and signaling pathways, enhancing its resistance against bacterial infection.

Published
2015

32. Decreased expression of Calpain-9 predicts unfavorable prognosis in patients with gastric cancer

Author

Peng, Peike, primary, Wu, Weicheng, additional, Zhao, Junjie, additional, Song, Shushu, additional, Wang, Xuefei, additional, Jia, Dongwei, additional, Shao, Miaomiao, additional, Zhang, Mingming, additional, Li, Lili, additional, Wang, Lan, additional, Duan, Fangfang, additional, Zhao, Ran, additional, Yang, Caiting, additional, Wu, Hao, additional, Zhang, Jie, additional, Shen, Zhenbin, additional, Ruan, Yuanyuan, additional, and Gu, Jianxin, additional

Published
2016
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35. A metabolomics study delineating geographical location-associated primary metabolic changes in the leaves of growing tobacco plants by GC-MS and CE-MS

Author

Zhao, Yanni, primary, Zhao, Jieyu, additional, Zhao, Chunxia, additional, Zhou, Huina, additional, Li, Yanli, additional, Zhang, Junjie, additional, Li, Lili, additional, Hu, Chunxiu, additional, Li, Wenzheng, additional, Peng, Xiaojun, additional, Lu, Xin, additional, Lin, Fucheng, additional, and Xu, Guowang, additional

Published
2015
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