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280 results on '"Lee, Sun"'

8. Clinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome

Author

Kim, Dong-Min, Yu, Byung Jun, Kim, Da Young, Seo, Jun-Won, Yun, Na-Ra, Kim, Choon Mee, Kim, Young Keun, Jung, Sook In, Kim, Uh Jin, Kim, Seong Eun, Kim, Hyun ah, Kim, Eu Suk, Hur, Jian, Lee, Sun Hee, Jeong, Hye Won, Heo, Jung Yeon, Jung, Dong Sik, Kim, Jieun, Park, Sun Hee, Kwak, Yee Gyung, Lee, Sujin, Lim, Seungjin, and Chatterjee, Shilpa

Published
2023
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11. Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation.

Author

Han, Dasol, Kwon, Mookwang, Lee, Sun Min, Pleasure, Samuel J, and Yoon, Keejung

Subjects
Astrocytes, Animals, Humans, Glial Fibrillary Acidic Protein, Ciliary Neurotrophic Factor, Oncogene Proteins, Transcription, Genetic, Embryonic Development, Bone Morphogenetic Protein 4
Abstract

Although astrocytes have gained increased recognition as an important regulator in normal brain function and pathology, the mechanisms underlying their genesis are not well understood. In this study, we show that constitutive YAP activation by in utero introduction of a non-degradable form of the YAP gene (YAP 5SA) causes productive GFAP+ cell generation at late embryonic periods, and this activity is nuclear localization- and TEAD transcription factor-dependent. Moreover, we found that the GFAP+ cells were not YAP 5SA-expressing cells themselves but cells in the vicinity in vivo. Conditioned medium prepared from YAP 5SA-expressing cells induced GFAP+ cell production in vitro, suggesting that a soluble factor(s) was mediating the astrogenic activity of YAP 5SA. Indeed, YAP 5SA expression greatly increased CNTF and BMP4 transcription in neural progenitor cells, and a neutralizing antibody against CNTF reduced the astrogenic effects of YAP 5SA-conditioned medium. Furthermore, the YAP 5SA-expressing cells were identified as FN1+ mesenchymal cells which are responsible for the precocious astrogenesis. These results suggest a novel molecular mechanism by which YAP activation can induce astrogenesis in a non-cell autonomous manner.

Published
2020

12. High energy electron beam stimulated nanowelding of silver nanowire networks encapsulated with graphene for flexible and transparent electrodes.

Author

Lee, Su, Lee, Young, Lim, Yi, Han, Jin, Jeon, In, Bae, Garam, Yoon, Yeoheung, Song, Wooseok, Myung, Sung, Lim, Jongsun, An, Ki-Seok, and Lee, Sun

Abstract

Low-dimensional nanostructures and their complementary hybridization techniques are in the vanguard of technological advances for applications in transparent and flexible nanoelectronics due to the intriguing electrical properties related to their atomic structure. In this study, we demonstrated that welding of Ag nanowires (NWs) encapsulated in graphene was stimulated by flux-optimized, high-energy electron beam irradiation (HEBI) under ambient conditions. This methodology can inhibit the oxidation of Ag NWs which is induced by the inevitably generated reactive ozone as well as improve of their electrical conductivity. We have systematically explored the effects of HEBI on Ag NWs and graphene. The optimized flux for HEBI welding of the Ag NWs with graphene was 150 kGy, which decreased the sheet resistance of the graphene/Ag NWs to 12 Ohm/sq. Following encapsulation with graphene, the initial chemical states of the Ag NWs were well-preserved after flux-tuned HEBI, whereas graphene underwent local HEBI-induced defect generation near the junction area. We further employed resonant Raman spectroscopy to follow the structural evolution of the sacrificial graphene in the hybrid film after HEBI. Notably, the sheet resistance of the welded Ag NWs encapsulated with graphene after HEBI was well-maintained even after 85 days.

Published
2019

15. Different clinical characteristics and impact of carbapenem-resistance on outcomes between Acinetobacter baumannii and Pseudomonas aeruginosa bacteraemia: a prospective observational study

Author

Lee, Chan Mi, Kim, Young-Jun, Jung, Sook-In, Kim, Seong Eun, Park, Wan Beom, Choe, Pyoeng Gyun, Kim, Eu Suk, Kim, Chung-Jong, Choi, Hee Jung, Lee, Shinwon, Lee, Sun Hee, Jung, Younghee, Bang, Ji Hwan, Cheon, Shinhye, Kwak, Yee Gyung, Kang, Yu Min, Park, Kyung-Hwa, Song, Kyoung-Ho, and Kim, Hong Bin

Published
2022
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27. Comparison of RT-PCR, RT-nested PCRs, and real-time PCR for diagnosis of severe fever with thrombocytopenia syndrome: a prospective study

Author

Jalal, Sehrish, Hwang, Seong Yeon, Kim, Choon-Mee, Kim, Dong-Min, Yun, Na Ra, Seo, Jun-Won, Young Kim, Da, Jung, Sook In, Kim, Uh Jin, Kim, Seong Eun, Kim, Hyun ah, Kim, Eu Suk, Hur, Jian, Kim, Young Keun, Jeong, Hye Won, Heo, Jung Yeon, Jung, Dong Sik, Kim, Jieun, Park, Sun Hee, Kwak, Yee Gyung, Lee, Sujin, Lim, Seungjin, and Lee, Sun Hee

Published
2021
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48. Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model

Author

Lee Sun, Ren-Huei Shiu, Rui Han, Hao Chi, Chung-Chuan Lo, Hui-Yun Chang, Tzu-Min Wei, Tzu-Kang Sang, and Chien-Ping Hsieh

Subjects
0301 basic medicine, Male, Hyperphosphorylation, lcsh:Medicine, Diseases, tau Proteins, Pathogenesis, Cleavage (embryo), Article, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, medicine, Genetics, Animals, Humans, Axon, Phosphorylation, Cytotoxicity, lcsh:Science, Actin, Neurons, Multidisciplinary, Chemistry, Neurodegeneration, lcsh:R, Neurofibrillary Tangles, medicine.disease, Subcellular localization, Axons, Cell biology, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Tauopathies, Soma, lcsh:Q, Drosophila, Female, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Neuroscience
Abstract

Hyperphosphorylated and truncated tau variants are enriched in neuropathological aggregates in diseases known as tauopathies. However, whether the interaction of these posttranslational modifications affects tau toxicity as a whole remains unresolved. By expressing human tau with disease-related Ser/Thr residues to simulate hyperphosphorylation, we show that despite severe neurodegeneration in full-length tau, with the truncation at Asp421, the toxicity is ameliorated. Cytological and biochemical analyses reveal that hyperphosphorylated full-length tau distributes in the soma, the axon, and the axonal terminal without evident distinction, whereas the Asp421-truncated version is mostly restricted from the axonal terminal. This discrepancy is correlated with the fact that fly expressing hyperphosphorylated full-length tau, but not Asp421-cleaved one, develops axonopathy lesions, including axonal spheroids and aberrant actin accumulations. The reduced presence of hyperphosphorylated tau in the axonal terminal is corroborated with the observation that flies expressing Asp421-truncated variants showed less motor deficit, suggesting synaptic function is preserved. The Asp421 cleavage of tau is a proteolytic product commonly found in the neurofibrillary tangles. Our finding suggests the coordination of different posttranslational modifications on tau may have an unexpected impact on the protein subcellular localization and cytotoxicity, which may be valuable when considering tau for therapeutic purposes.

Published
2020

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