Search

Your search keyword '"Lee, Hyun Ju"' showing total 12 results
Start Over Author "Lee, Hyun Ju" Journal scientific reports
12 results on '"Lee, Hyun Ju"'

10. Author Correction: Neuronal activity regulates DROSHA via autophagy in spinal muscular atrophy

Author

Gonçalves, Inês do Carmo G., primary, Brecht, Johanna, additional, Thelen, Maximilian P., additional, Rehorst, Wiebke A., additional, Peters, Miriam, additional, Lee, Hyun Ju, additional, Motameny, Susanne, additional, Torres-Benito, Laura, additional, Ebrahimi-Fakhari, Darius, additional, Kononenko, Natalia L., additional, Altmüller, Janine, additional, Vilchez, David, additional, Sahin, Mustafa, additional, Wirth, Brunhilde, additional, and Kye, Min Jeong, additional

Published
2018
Full Text
View/download PDF

12. Intravitreal TSG-6 suppresses laser-induced choroidal neovascularization by inhibiting CCR2+ monocyte recruitment.

Author

Kim SJ, Lee HJ, Yun JH, Ko JH, Choi DY, and Oh JY

Subjects
Animals, Bruch Membrane radiation effects, Cell Adhesion Molecules genetics, Cell Adhesion Molecules metabolism, Choroid metabolism, Choroidal Neovascularization etiology, Choroidal Neovascularization metabolism, Cytokines metabolism, Disease Models, Animal, Lasers, Monocytes metabolism, Rats, Recombinant Proteins biosynthesis, Recombinant Proteins isolation & purification, Recombinant Proteins pharmacology, Retina drug effects, Retina metabolism, Vascular Endothelial Growth Factor A metabolism, Cell Adhesion Molecules pharmacology, Choroid drug effects, Choroidal Neovascularization pathology, Monocytes cytology, Receptors, CCR2 metabolism
Abstract

Choroidal neovascularization (CNV) is the hallmark of wet age-related macular degeneration (AMD), one of the leading causes of blindness in the elderly. Although the pathogenesis of CNV is not clear, a number of studies show that ocular-infiltrating macrophages and inflammation play a critical role in the development of CNV. TNFα-stimulated gene/protein (TSG)-6 is a multifunctional endogenous protein that has anti-inflammatory activities partly by regulating macrophage activation. Therefore, we here investigated the therapeutic potential of TSG-6 in a rat model of CNV induced by laser photocoagulation. Time course analysis showed that the expression of VEGF and pro-inflammatory cytokines in the choroid was up-regulated early after laser injury, and gradually decreased to baseline over 14 days. An intravitreal injection of TSG-6 suppressed the expression of VEGF and pro-inflammatory cytokines including CCL2, and reduced the size of CNV. Also, the number of Iba(+) and CCR2(+) cells including infiltrating macrophages was markedly lower in the CNV lesion of TSG-6-treated eyes. Further analysis identified CCR2(+) CD11b(+) CD11c(+) cells and CCR2(+) CD11b(-)CD11c(+) cells as the cell populations that were increased by laser injury and reduced by TSG-6 treatment. Together, the results demonstrate that TSG-6 inhibits inflammation and CCR2(+) monocyte recruitment into the choroid, and suppresses the development of CNV.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results