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1,002 results on '"LIU, Wei"'

1. Dynamics analysis of green supply chain under the conditions of demand uncertainty and blockchain technology

Author

Liu-wei Zhao, Shuai Jin, and Peng Gao

Subjects
Green Supply Chain, Blockchain Technology, Demand Uncertainty, Blockchain Acceptance, Green Uncertainty, Medicine, Science
Abstract

Abstract This research investigates the implications of incorporating blockchain technology into the process of making decisions for green supply chains, particularly under conditions of demand uncertainty. A model was formulated to encompass both environmentally friendly products enabled by blockchain technology and those without such enabling technology. The study further explores the optimal method of introducing green input in a duopoly market using game theory. It also examines how consumer uncertainty about green products and acceptance of the technical parameters of blockchain influence this strategy. The findings suggest that increased consumer uncertainty can, in some instances, motivate manufacturers to enhance the eco-friendliness of their products and improve supply chain performance. However, the universal adoption of blockchain does not necessarily ensure better results; on the contrary, it may compromise product sustainability while enhancing supply chain profitability. Moreover, research has indicated that products enabled by blockchain typically have lower prices, thereby offering potential benefits to consumers when acceptance of sustainable energy solutions is high or uncertain. Additionally, this paper analyzes the impact of changes in green supply chain decision-making on system reliability. This involves exploring the relationship between decision parameters and consumer reluctance towards sustainable products and the adoption of blockchain technology. To ensure stable market competition in dynamic complex systems, research shows that feedback control technology can effectively regulate unpredictable behavior.

Published
2024
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46. Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

Author

Liu, Wei-Liang, Hsu, Chia-Wei, Chan, Shih-Peng, Yen, Pei-Shi, Su, Matthew P, Li, Jian-Chiuan, Li, Hsing-Han, Cheng, Lie, Tang, Cheng-Kang, Ko, Shih-Hsun, Tsai, Huai-Kuang, Tsai, Zing Tsung-Yeh, Akbari, Omar S, Failloux, Anna-Bella, and Chen, Chun-Hong

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Vaccine Related, Emerging Infectious Diseases, Biodefense, Biotechnology, Infectious Diseases, Rare Diseases, Vector-Borne Diseases, Prevention, Genetics, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Aedes, Animals, Animals, Genetically Modified, Cell Line, Cricetinae, Cricetulus, Dengue, Dengue Virus, Fibroblasts, Mosquito Control, Mosquito Vectors, RNA, Small Interfering, Serogroup, Transposases, Viral Load
Abstract

The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated to the mosquito's salivary glands for amplification. Thus, blocking virus infection or replication in the tissues of the mosquito may be a viable strategy for reducing the incidence of DENV transmission to humans. Here we used the mariner Mos1 transposase to create an Aedes aegypti line that expresses virus-specific miRNA hairpins capable of blocking DENV replication. These microRNA are driven by the blood-meal-inducible carboxypeptidase A promoter or by the polyubiquitin promoter. The transgenic mosquitoes exhibited significantly lower infection rates and viral titers for most DENV serotypes 7 days after receiving an infectious blood meal. The treatment was also effective at day 14 post infection after a second blood meal had been administered. In viral transmission assay, we found there was significantly reduced transmission in these lines. These transgenic mosquitoes were effective in silencing most of the DENV genome; such an approach may be employed to control a dengue fever epidemic.

Published
2021

47. Metabolomics for early detection of stress in freshwater alga Poterioochromonas malhamensis exposed to silver nanoparticles.

Author

Liu, Wei, Majumdar, Sanghamitra, Li, Weiwei, Keller, Arturo A, and Slaveykova, Vera I

Abstract

Silver nanoparticles (AgNPs) are one of the most used engineered nanomaterials. Despite progress in assessing their environmental implications, knowledge gaps exist concerning the metabolic perturbations induced by AgNPs on phytoplankton, essential organisms in global biogeochemical cycles and food-web dynamics. We combine targeted metabolomics, biouptake and physiological response studies to elucidate metabolic perturbations in alga Poterioochromonas malhamensis induced by AgNPs and dissolved Ag. We show time-dependent perturbation of the metabolism of amino acids, nucleotides, fatty acids, tricarboxylic acids, photosynthesis and photorespiration by both Ag-treatments. The results suggest that dissolved Ag ions released by AgNPs are the major toxicity driver; however, AgNPs internalized in food vacuoles contributed to the perturbation of amino acid metabolism, TCA cycle and oxidative stress. The metabolic perturbations corroborate the observed physiological responses. We highlight the potential of metabolomics as a tool for understanding the molecular basis for these metabolic and physiological changes, and for early detection of stress.

Published
2020

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