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1,425 results on '"LI, Yan"'

27. High speed photo-mediated ultrasound therapy integrated with OCTA.

Author

Li, Yan, Song, Yuchen, Li, Runze, Jia, Wangcun, Zhang, Fengyi, Hu, Xiaoming, Chou, Lidek, Zhou, Qifa, and Chen, Zhongping

Subjects
Animals, Rabbits, Tomography, Optical Coherence, Fluorescein Angiography, Ultrasonic Therapy, Lasers, Biomedical Imaging, Cardiovascular
Abstract

Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually. Here, we report the development of a high speed PUT system based on a 50-kHz pulsed laser to achieve faster treatment, decreasing the treatment time by a factor of 20. Furthermore, we integrated it with optical coherence tomography angiography (OCTA) for real time monitoring. The feasibility of the proposed OCTA-guided PUT was validated through in vivo rabbit experiments. The addition of OCTA to PUT allows for quantitative prescreening and real time monitoring of treatment response, thereby enabling implementation of individualized treatment strategies.

Published
2022

48. Intravascular polarization-sensitive optical coherence tomography based on polarization mode delay

Author

Li, Yan, Moon, Sucbei, Jiang, Yuchen, Qiu, Saijun, and Chen, Zhongping

Subjects
Bioengineering, Breast Cancer, Cancer, Biomedical Imaging, Generic health relevance, Birefringence, Coronary Vessels, Refraction, Ocular, Tendons, Tomography, Optical Coherence
Abstract

Intravascular polarization-sensitive optical coherence tomography (IV-PSOCT) provides depth-resolved tissue birefringence which can be used to evaluate the mechanical stability of a plaque. In our previous study, we reported a new strategy to construct polarization-sensitive optical coherence tomography in a microscope platform. Here, we demonstrated that this technology can be implemented in an endoscope platform, which has many clinical applications. A conventional intravascular OCT system can be modified for IV-PSOCT by introducing a 12-m polarization-maintaining fiber-based imaging probe. Its two polarization modes separately produce OCT images of polarization detection channels spatially distinguished by an image separation of 2.7 mm. We experimentally validated our IV-PSOCT with chicken tendon, chicken breast, and coronary artery as the image samples. We found that the birefringent properties can be successfully visualized by our IV-PSOCT.

Published
2022

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