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2 results on '"Josep Clotet"'

1. Association between soluble angiotensin-converting enzyme 2 in saliva and SARS-CoV-2 infection: a cross-sectional study

Author

Samuel Bru, Pedro Brotons, Iolanda Jordan, Laia Alsina, Desiree Henares, Reyes Carballar, Mariona Fernandez de Sevilla, Irene Barrabeig, Victoria Fumado, Bàrbara Baro, Joan Marc Martínez-Láinez, Juan J. Garcia-Garcia, Quique Bassat, Albert Balaguer, Josep Clotet, Cristian Launes, and Carmen Muñoz-Almagro

Subjects
Medicine, Science
Abstract

Abstract This study aimed to investigate the association between saliva soluble angiotensin-converting enzyme 2 (sACE2) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adults. We selected a convenience sample of adults with post-acute SARS-CoV-2 infection and their household children living in quarantined family households of the metropolitan Barcelona region (Spain) during the spring 2020 pandemic national lockdown. Participants were tested for saliva sACE2 quantification by western blot and nasopharyngeal SARS-CoV-2 RT-PCR detection. A total of 161 saliva samples [82 (50.9%) from children; 79 (49.1%) from females] yielded valid western blot and RT-PCR results. Saliva sACE2 was detected in 79 (96.3%) children and 76 (96.2%) convalescent adults. Twenty (24.4%) children and 20 (25.3%) convalescent adults were positive for SARS-CoV-2 in nasopharynx by RT-PCR. SARS-CoV-2 RT-PCR-negative children had a significantly higher mean proportional level of saliva sACE2 (0.540 × 10–3%) than RT-PCR-positive children (0.192 × 10–3%, p

Published
2023
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2. The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration

Author

Stephen J. Kron, Eva Quandt, Miquel Àngel Carrasco-García, Josep Clotet, Sara Hernández-Ortega, Laura Gasa, Javier Jiménez, August Vidal, Alberto Villanueva, Pau Mezquita, Mariana P.C. Ribeiro, Abril Sánchez-Botet, and Universitat de Barcelona

Subjects
tumors, Male, 0301 basic medicine, Colorectal cancer, lcsh:Medicine, tumours, medicine.disease_cause, CNTD2, Mice, 0302 clinical medicine, Cell Movement, lcsh:Science, Cell proliferation, Cyclin, Proliferació cel·lular, Mutation, Migració cel·lular, Multidisciplinary, Colon cancer cell, Ciclines, colon cancer, cáncer de colon, 030220 oncology & carcinogenesis, Colonic Neoplasms, Female, càncer de colon, Proto-Oncogene Proteins B-raf, Mutation, Missense, Mice, Nude, 616.3, Biology, Article, 03 medical and health sciences, Downregulation and upregulation, Càncer colorectal, In vivo, Cell Line, Tumor, Cyclins, medicine, Animals, Humans, Cell migration, neoplasms, Cell Proliferation, lcsh:R, medicine.disease, digestive system diseases, 030104 developmental biology, Amino Acid Substitution, tumores, Cell culture, Cancer research, lcsh:Q, V600E
Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide, with 8–10% of these tumours presenting a BRAF (V600E) mutation. Cyclins are known oncogenes deregulated in many cancers, but the role of the new subfamily of atypical cyclins remains elusive. Here we have performed a systematic analysis of the protein expression levels of eight atypical cyclins in human CRC tumours and several cell lines, and found that CNTD2 is significantly upregulated in CRC tissue compared to the adjacent normal one. CNTD2 overexpression in CRC cell lines increases their proliferation capacity and migration, as well as spheroid formation capacity and anchorage-independent growth. Moreover, CNTD2 increases tumour growth in vivo on xenograft models of CRC with wild-type BRAF. Accordingly, CNTD2 downregulation significantly diminished the proliferation of wild-type BRAF CRC cells, suggesting that CNTD2 may represent a new prognostic factor and a promising drug target in the management of CRC.

Published
2018
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