1. Impact of Anemia and Dual Antiplatelet Therapy on Mortality in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents
- Author
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Ling Zhang, Dayi Hu, Jinguo Fu, Xian Wang, Huili Wang, Lufeng Ma, Jun Zhang, Yuan Yang, Shouyan Zhang, and Rongjing Ding
- Subjects
Male ,medicine.medical_specialty ,Anemia ,medicine.medical_treatment ,Renal function ,Coronary Artery Disease ,Kaplan-Meier Estimate ,Severity of Illness Index ,Article ,Hemoglobins ,Percutaneous Coronary Intervention ,Internal medicine ,hemic and lymphatic diseases ,Severity of illness ,medicine ,Humans ,cardiovascular diseases ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Multidisciplinary ,Aspirin ,business.industry ,Proportional hazards model ,Percutaneous coronary intervention ,Retrospective cohort study ,Drug-Eluting Stents ,Middle Aged ,medicine.disease ,Thrombocytopenia ,Surgery ,Conventional PCI ,Female ,Hemoglobin ,business ,Platelet Aggregation Inhibitors ,Follow-Up Studies ,Glomerular Filtration Rate - Abstract
The objective was to assess the impact of baseline anemia on all-cause mortality and whether 12-month dual antiplatelet therapy (DAPT) affects 1-year mortality linked to anemia in patients after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). 4109 enrolled patients divided into three groups based on their pre-procedural hemoglobin (Hb) level: Hb P = 0.017; HR 3.93, 95% CI 1.11 to 13.98, P = 0.034) and in long-term mortality between anemia and no anemia groups (HR 1.82, 95% CI 1.17 to 2.83, P = 0.008 for mild anemia; HR 3.19,95% CI 1.29 to 7.86, P = 0.012 for moderate-severe anemia). There was not significant interaction between 12-month DAPT and anemia on mortality in anemic patients (P for interaction > 0.05). Anemia shows association with increased all-cause mortality in patients undergoing PCI. Twelve-month DAPT does not show synergy with anemia to increase the risk of all-cause 1-year mortality in anemic patients after PCI.
- Published
- 2015
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