16 results on '"Jian Han"'
Search Results
2. Precipitates and Particles Coarsening of 9Cr–1.7W–0.4Mo–Co Ferritic Heat-Resistant Steel after Isothermal Aging
- Author
-
Qiuzhi Gao, Yanan Zhang, Hailian Zhang, Huijun Li, Fu Qu, Jian Han, Cheng Lu, Bintao Wu, Yao Lu, and Yan Ma
- Subjects
Medicine ,Science - Abstract
Abstract The precipitates obtained by EPE technology from the 9Cr-1.7W-0.4Mo-Co ferritic heat-resistant steel subject to isothermal aging were investigated using SEM, TEM and XRD. The particle size distribution and the coarsening kinetics of M23C6 with duration of isothermal aging were also analyzed with or without consideration of Laves phase. The results show that the isolated dislocations were detected in delta ferrite interior, and the precipitates on delta ferrite and martensite boundaries are obviously larger than other locations. Fe2W-Laves phase can only be found as duration of aging time to 2000 h, and is preferential to form adjacent to M23C6 particles. The small M23C6 particles firstly coarsen, but the large M23C6 are relatively stable during short aging. The total coarsening rate of M23C6 precipitates is 9.75 × 10−28m3s−1, and the coarsening of M23C6 depends on the formation of Laves phase.
- Published
- 2017
- Full Text
- View/download PDF
3. Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells
- Author
-
Jian Han, Jia Li, Jolene Caifeng Ho, Grace Sushin Chia, Hiroyuki Kato, Sudhakar Jha, Henry Yang, Lorenz Poellinger, and Kian Leong Lee
- Subjects
Medicine ,Science - Abstract
Abstract Adaptation to hypoxia, a hallmark feature of many tumors, is an important driver of cancer cell survival, proliferation and the development of resistance to chemotherapy. Hypoxia-induced stabilization of hypoxia-inducible factors (HIFs) leads to transcriptional activation of a network of hypoxia target genes involved in angiogenesis, cell growth, glycolysis, DNA damage repair and apoptosis. Although the transcriptional targets of hypoxia have been characterized, the alternative splicing of transcripts that occurs during hypoxia and the roles they play in oncogenesis are much less understood. To identify and quantify hypoxia-induced alternative splicing events in human cancer cells, we performed whole transcriptome RNA-Seq in breast cancer cells that are known to provide robust transcriptional response to hypoxia. We found 2005 and 1684 alternative splicing events including intron retention, exon skipping and alternative first exon usage that were regulated by acute and chronic hypoxia where intron retention was the most dominant type of hypoxia-induced alternative splicing. Many of these genes are involved in cellular metabolism, transcriptional regulation, actin cytoskeleton organisation, cancer cell proliferation, migration and invasion, suggesting they may modulate or be involved in additional features of tumorigenic development that extend beyond the known functions of canonical full-length transcripts.
- Published
- 2017
- Full Text
- View/download PDF
4. A pilot study of non-invasive diagnostic tools to detect Helicobacter pylori infection and peptic ulcer disease
- Author
-
Liao, En-Chih, Yu, Ching-Hsiang, Lai, Jian-Han, Lin, Ching-Chung, Chen, Chih-Jen, Chang, Wen-Han, and Chien, Ding-Kuo
- Published
- 2023
- Full Text
- View/download PDF
5. Congenital collagenopathies increased the risk of inguinal hernia developing and repair: analysis from a nationwide population-based cohort study
- Author
-
Chang, Hao-Han, Juan, Yung-Shun, Li, Ching-Chia, Lee, Hsiang-Ying, and Chen, Jian-Han
- Published
- 2022
- Full Text
- View/download PDF
6. Check point to get adequate weight loss within 6-months after laparoscopic sleeve gastrectomy for morbid obesity in Asian population
- Author
-
Chen, Chung-Yen, Lee, Cheng-Hung, Lee, Hui-Ming, Yin, Wen-Yao, Chin, Wei-Leng, Lee, Ming-Hsien, and Chen, Jian-Han
- Published
- 2020
- Full Text
- View/download PDF
7. Check point to get adequate weight loss within 6-months after laparoscopic sleeve gastrectomy for morbid obesity in Asian population
- Author
-
Ming-Hsien Lee, Hui-Ming Lee, Jian-Han Chen, C. S. Chen, Wei-Leng Chin, Wen-Yao Yin, and Cheng-Hung Lee
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,lcsh:Medicine ,030209 endocrinology & metabolism ,Logistic regression ,Article ,Morbid obesity ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Patient Education as Topic ,Weight loss ,Gastrectomy ,Internal medicine ,Weight Loss ,medicine ,Humans ,Obesity ,lcsh:Science ,Life Style ,Laparoscopic sleeve gastrectomy ,Multidisciplinary ,business.industry ,lcsh:R ,medicine.disease ,Obesity, Morbid ,Treatment Outcome ,Risk factors ,Asian population ,lcsh:Q ,030211 gastroenterology & hepatology ,Female ,Laparoscopy ,medicine.symptom ,business ,Check point ,Body mass index ,Follow-Up Studies - Abstract
Purpose of this study is to develope a scoring system to predict the likelihood of excess body weight loss (EBWL) ≥ 50% 6-months after laparoscopic sleeve gastrectomy (LSG). From April 2016 to September 2018, data was collected from 160 patients (BMI ≥ 32) who underwent primary LSG with at least 6-months follow-up. They were separated into score generation (operated by one surgeon, n = 122) and validation groups (operated by 3 different surgeons, n = 38). EBWL at 6-months ≥ 50% was considered adequate weight loss. Independent variables including age, gender, initial body mass index (BMI), comorbidities, life-style habits, percentage of EBWL and percentage of total body weight loss at 1-week, 1-month, and 3-months were analyzed with mutivariate logistic regression to generate the scoring system. The system was applied to internal and external validation groups to determine efficacy. As results, between the score generation and internal validation groups, the only significant difference in patient characteristics was in exercise participation. EBWL at 1-month > 19.5% (1 point) and EBWL at 3-months > 37.7% (2 points) were identified as independent factors to predict EBWL at 6-months ≥ 50%. When scores were > 1, the system had 94.03% positive predictive value (PPV) and 81.82% negative predictive value (NPV) (AUC: 0.923). Internal validation scores > 1 had a 95.83% PPV and 85.71% NPV (AUC: 0.975). External validation results showed 88.59% PPV and 72.00% NPV (AUC: 0.802). We concluded that this scoring system provides a reliable, objective prediction of EBWL at 6-months ≥ 50%. Patients requiring more aggressive clinical follow-up and intervention can be detected as early as 1- to 3-months after LSG.
- Published
- 2020
8. Sclerite-bearing annelids from the lower Cambrian of South China
- Author
-
Jennifer F. Hoyal Cuthill, Simon Conway Morris, Jian Han, and Degan Shu
- Subjects
0301 basic medicine ,Sclerite ,China ,South china ,Paleozoic ,Annelida ,lcsh:Medicine ,Zoology ,Lagerstätte ,Article ,03 medical and health sciences ,Chaeta ,Wiwaxia ,0302 clinical medicine ,Animals ,lcsh:Science ,Phylogeny ,Multidisciplinary ,Annelid ,biology ,Fossils ,lcsh:R ,biology.organism_classification ,Biological Evolution ,030104 developmental biology ,Taxon ,Mollusca ,lcsh:Q ,030217 neurology & neurosurgery - Abstract
Cambrian annelids are strikingly diverse and reveal important details of annelid character acquisition. Their contribution, however, to a wider understanding of the evolution of the trochozoans (encompassing the annelids as well as such groups as the brachiopods and molluscs) remains limited. Thus the early annelids had been linked to a variety of cataphract Cambrian metazoans, notably Wiwaxia and the halkieriids, but recent work assigns such fossils to stem-group molluscs. Here we report two new annelids from the Lower Cambrian Chengjiang Lagerstätte, South China. Ipoliknus avitus n. gen., n. sp. is biramous with neurochaetae and notochaetae, but significantly also bears dorsal spinose sclerites and dorso-lateral dentate sclerites. Adelochaeta sinensis n. gen., n. sp. is unique amongst Cambrian polychaetes in possessing the rod-like supports of the parapodia known as aciculae. This supports phylogenetic placement of Adelochaeta as sister to some more derived aciculate Palaeozoic taxa, but in contrast Ipoliknus is recovered as the most basal of the stem-group annelids. Sclerites and chaetae of I. avitus are interpreted respectively as the remnants and derivatives of a once more extensive cataphract covering that was a characteristic of more primitive trochozoans. The two sets of chaetae (noto- and neurochaetae) and two sets of sclerites (spinose and dentate) suggest that in a pre-annelid an earlier and more complete scleritome may have consisted of four zones of sclerites. Other cataphract taxa from the Lower Palaeozoic show a variety of scleritome configurations but establishing direct links with such basal annelids as Ipoliknus at present must remain conjectural.
- Published
- 2018
9. Precipitates and Particles Coarsening of 9Cr–1.7W–0.4Mo–Co Ferritic Heat-Resistant Steel after Isothermal Aging
- Author
-
Bintao Wu, Yan Ma, Huijun Li, Yao Lu, Fu Qu, Hailian Zhang, Cheng Lu, Jian Han, Qiuzhi Gao, and Yanan Zhang
- Subjects
010302 applied physics ,Heat resistant ,Multidisciplinary ,Materials science ,Science ,Kinetics ,02 engineering and technology ,Laves phase ,021001 nanoscience & nanotechnology ,01 natural sciences ,Isothermal process ,Article ,Ferrite (iron) ,Martensite ,0103 physical sciences ,Particle-size distribution ,Medicine ,Composite material ,0210 nano-technology - Abstract
The precipitates obtained by EPE technology from the 9Cr-1.7W-0.4Mo-Co ferritic heat-resistant steel subject to isothermal aging were investigated using SEM, TEM and XRD. The particle size distribution and the coarsening kinetics of M23C6 with duration of isothermal aging were also analyzed with or without consideration of Laves phase. The results show that the isolated dislocations were detected in delta ferrite interior, and the precipitates on delta ferrite and martensite boundaries are obviously larger than other locations. Fe2W-Laves phase can only be found as duration of aging time to 2000 h, and is preferential to form adjacent to M23C6 particles. The small M23C6 particles firstly coarsen, but the large M23C6 are relatively stable during short aging. The total coarsening rate of M23C6 precipitates is 9.75 × 10−28m3s−1, and the coarsening of M23C6 depends on the formation of Laves phase.
- Published
- 2017
10. Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx
- Author
-
Ping Han, Jian Han, Mengke Li, Jiazhi Liao, Jiayi He, Wei Tu, Mei Liu, Yunwu Wang, Dean Tian, Jingmei Liu, and Jin Gong
- Subjects
Liver Cirrhosis ,Transcriptional Activation ,0301 basic medicine ,MAPK/ERK pathway ,Hepatitis B virus ,MAP Kinase Signaling System ,medicine.medical_treatment ,Mice, Transgenic ,Article ,Cell Line ,Mice ,03 medical and health sciences ,Paracrine signalling ,Hepatitis B, Chronic ,Fibrosis ,Cell Line, Tumor ,Paracrine Communication ,Hepatic Stellate Cells ,medicine ,Animals ,Humans ,Viral Regulatory and Accessory Proteins ,Author Correction ,Cell Proliferation ,Platelet-Derived Growth Factor ,Multidisciplinary ,Interleukin-6 ,Chemistry ,Growth factor ,Connective Tissue Growth Factor ,Matrix Attachment Region Binding Proteins ,SATB1 ,medicine.disease ,digestive system diseases ,Up-Regulation ,Mice, Inbred C57BL ,CTGF ,HBx ,030104 developmental biology ,Liver ,Hepatocytes ,Trans-Activators ,Cancer research ,Hepatic stellate cell ,HeLa Cells - Abstract
Chronic hepatitis B virus (HBV) infection is a major cause of chronic liver diseases, but its involvement in hepatic fibrogenesis remains unclear. Special AT-rich binding protein 1 (SATB1) has been implicated in reprogramming chromatin organization and transcription profiles in many cancers and non-cancer-related conditions. We found that hepatic SATB1 expression was significantly up-regulated in fibrotic tissues from chronic hepatitis B virus (HBV)-infected patients and HBV transgenic (HBV-Tg) mouse model. Knockdown of SATB1 in the liver significantly alleviated CCl4-induced fibrosis in HBV-Tg mouse model. Moreover, we suggested HBV encoded x protein (HBx) induced SATB1 expression through activation of JNK and ERK pathways. Enforced expression of SATB1 in hepatocytes promoted the activation and proliferation of hepatic stellate cells (HSCs) by secretion of connective tissue growth factor (CTGF), Interleukin-6 (IL-6) and platelet derived growth factor-A (PDGF-AA). Our findings demonstrated that HBx upregulated hepatic SATB1 which exerted pro-fibrotic effects by paracrine activation of stellate cells in HBV-related fibrosis.
- Published
- 2016
11. Experimental Trapped-ion Quantum Simulation of the Kibble-Zurek dynamics in momentum space
- Author
-
Jin-Ming Cui, Jian Wang, Wei-Min Lv, Adolfo del Campo, Yong-Jian Han, Zhao Wang, Le Luo, Guo Guangcan, Dong-Yang Cao, Chuan-Feng Li, and Yun-Feng Huang
- Subjects
Condensed Matter::Quantum Gases ,Physics ,Quantum Physics ,Multidisciplinary ,FOS: Physical sciences ,Quantum simulator ,Position and momentum space ,Space (mathematics) ,01 natural sciences ,Article ,010305 fluids & plasmas ,Ion ,Quantum mechanics ,0103 physical sciences ,Ising model ,Quantum Physics (quant-ph) ,010306 general physics ,Ground state ,Quantum ,Scaling - Abstract
The Kibble-Zurek mechanism is the paradigm to account for the nonadiabatic dynamics of a system across a continuous phase transition. Its study in the quantum regime is hindered by the requisite of ground state cooling. We report the experimental quantum simulation of critical dynamics in the transverse-field Ising model by a set of Landau-Zener crossings in pseudo-momentum space, that can be probed with high accuracy using a single trapped ion. We test the Kibble-Zurek mechanism in the quantum regime in the momentum space and find the measured scaling of excitations is in accordance with the theoretical prediction., Comment: 10 pages, 3 figures Published in Scientific Reports, http://www.nature.com/articles/srep33381
- Published
- 2016
- Full Text
- View/download PDF
12. Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients
- Author
-
Miranda Byrne-Steele, Lili Wang, Dongni Hou, Jie Liu, Tianlei Ying, Tao Li, Eric J. Seeley, Xinjun Tang, Jieming Qu, Zhiyong Zhang, Xiuhong Xi, Chunxue Bai, Chunlin Wang, Qin Wang, Cuicui Chen, Jian Zhou, Jian Han, Jianqing Xu, Yuanlin Song, and Shuihua Lu
- Subjects
0301 basic medicine ,Multidisciplinary ,T cell ,Repertoire ,Biology ,medicine.disease_cause ,Virology ,Influenza A virus subtype H5N1 ,Virus ,Deep sequencing ,Article ,03 medical and health sciences ,030104 developmental biology ,Immune system ,medicine.anatomical_structure ,Immunology ,medicine ,biology.protein ,Antibody ,human activities ,B cell - Abstract
Specific changes in immune repertoires at genetic level responding to the lethal H7N9 virus are still poorly understood. We performed deep sequencing on the T and B cells from patients recently infected with H7N9 to explore the correlation between clinical outcomes and immune repertoire alterations. T and B cell repertoires display highly dynamic yet distinct clonotype alterations. During infection, T cell beta chain repertoire continues to contract while the diversity of immunoglobulin heavy chain repertoire recovers. Patient recovery is correlated to the diversity of T cell and B cell repertoires in different ways – higher B cell diversity and lower T cell diversity are found in survivors. The sequences clonally related to known antibodies with binding affinity to H7 hemagglutinin could be identified from survivors. These findings suggest that utilizing deep sequencing may improve prognostication during influenza infection and could help in development of antibody discovery methodologies for the treatment of virus infection.
- Published
- 2016
13. Experimental Demonstration of a Hybrid-Quantum-Emitter Producing Individual Entangled Photon Pairs in the Telecom Band
- Author
-
Geng Chen, Bi-Heng Liu, Guo-Wei Zha, Chuan-Feng Li, Zhi-Chuan Niu, Wen-Hao Zhang, Zi-Huai Zhang, Guang-Can Guo, Ying Yu, Ni Haiqiao, De-Yong He, Jian-Shun Tang, Yang Zou, Zong-Quan Zhou, and Yong-Jian Han
- Subjects
Physics ,Multidisciplinary ,Photon ,business.industry ,Lithium niobate ,Nanowire ,Physics::Optics ,02 engineering and technology ,Quantum entanglement ,021001 nanoscience & nanotechnology ,01 natural sciences ,Article ,chemistry.chemical_compound ,chemistry ,Spontaneous parametric down-conversion ,Quantum dot ,Single-photon source ,0103 physical sciences ,010306 general physics ,0210 nano-technology ,Telecommunications ,business ,Entanglement witness - Abstract
Quantum emitters generating individual entangled photon pairs (IEPP) have significant fundamental advantages over schemes that suffer from multiple photon emission, or schemes that require post-selection techniques or the use of photon-number discriminating detectors. Quantum dots embedded within nanowires (QD-NWs) represent one of the most promising candidate for quantum emitters that provide a high collection efficiency of photons. However, a quantum emitter that generates IEPP in the telecom band is still an issue demanding a prompt solution. Here, we demonstrate in principle that IEPPs in the telecom band can be created by combining a single QD-NW and a nonlinear crystal waveguide. The QD-NW system serves as the single photon source, and the emitted visible single photons are split into IEPPs at approximately 1.55 μm through the process of spontaneous parametric down conversion (SPDC) in a periodically poled lithium niobate (PPLN) waveguide. The compatibility of the QD-PPLN interface is the determinant factor in constructing this novel hybrid-quantum-emitter (HQE). Benefiting from the desirable optical properties of QD-NWs and the extremely high nonlinear conversion efficiency of PPLN waveguides, we successfully generate IEPPs in the telecom band with the polarization degree of freedom. The entanglement of the generated photon pairs is confirmed by the entanglement witness. Our experiment paves the way to producing HQEs inheriting the advantages of multiple systems.
- Published
- 2016
- Full Text
- View/download PDF
14. A sclerite-bearing stem group entoproct from the early Cambrian and its implications
- Author
-
Xingliang Zhang, Guoxiang Li, Aodhán D. Butler, Lars E. Holmer, Zhifei Zhang, Jian Han, Dongjing Fu, Graham E. Budd, Degan Shu, Glenn A. Brock, Jianni Liu, Haizhou Wang, and Christian B. Skovsted
- Subjects
Holdfast ,Sclerite ,Time Factors ,Multidisciplinary ,biology ,Fossils ,Phylum ,Lophotrochozoa ,Anatomy ,biology.organism_classification ,Biological Evolution ,Invertebrates ,Article ,Calyx ,Paleontology ,Body plan ,Naturvetenskap ,Microscopy, Electron, Scanning ,Animals ,Protostome ,Cotyledion ,Natural Sciences - Abstract
The Lophotrochozoa includes disparate tentacle-bearing sessile protostome animals, which apparently appeared in the Cambrian explosion, but lack an uncontested fossil record. Here we describe abundant well preserved material of Cotyledion tylodes Luo et Hu, 1999, from the Cambrian (Series 2) Chengjiang deposits, reinterpreted here as a stem-group entoproct. The entoproct affinity is supported by the sessile body plan and interior soft anatomy. The body consists of an upper calyx and a lower elongate stalk with a distal holdfast. The soft anatomy includes a U-shaped gut with a mouth and aboral anus ringed by retractable marginal tentacles. Cotyledion differs from extant entoprocts in being larger and having the calyx and the stalk covered by numerous loosely-spaced external sclerites. The description of entoprocts from the Chengjiang biota traces the ancestry of yet another lophotrochozoan phylum back to the Cambrian radiation and has important implications for the earliest evolution of lophotrochozoans.
- Published
- 2013
15. A pilot study of non-invasive diagnostic tools to detect Helicobacter pylori infection and peptic ulcer disease
- Author
-
En-Chih Liao, Ching-Hsiang Yu, Jian-Han Lai, Ching-Chung Lin, Chih-Jen Chen, Wen-Han Chang, and Ding-Kuo Chien
- Subjects
Medicine ,Science - Abstract
Abstract Helicobacter pylori (H. pylori) infection can lead to various digestive system diseases, making accurate diagnosis crucial. However, not all available tests are equally non-invasive and sensitive. This study aimed to compare the efficacy of non-invasive and invasive diagnostic tools for H. pylori infection and assess their correlation with esophagogastroduodenoscopic (EGD) findings. The study utilized the Campylobacter-Like Organism (CLO) test, serum anti-HP IgG blood test, and C-13-urea breath test (UBT) to diagnose H. pylori infection. A total of 100 patients with peptic ulcer symptoms, including 45 males and 55 females, were recruited for the study. Symptomatic patients between the ages of 20–70, eligible for EGD examination, were enrolled. Each diagnostic test and any combination of two positive tests were considered the reference standard and compared against the other diagnostic methods. Additionally, the relationship between these diagnostic tests and EGD findings was evaluated. Among the participants, 74.0% were diagnosed with peptic ulcer disease through EGD. The UBT demonstrated the highest Youden's index, ranging from 58 to 100%, against all the non-invasive tests. The IgG blood test displayed the highest sensitivity at 100%, with a specificity of 60–70%. On the other hand, the CLO test exhibited the highest specificity at 100% and a sensitivity of 50–85%. Furthermore, only the CLO test showed a significant association with esophageal ulcers (p-value = 0.01). The IgG blood test holds promise as a primary screening tool due to its exceptional sensitivity. While the UBT is relatively expensive, its non-invasive nature and high sensitivity and specificity make it a potential standalone diagnostic test for H. pylori infection. Moreover, the noteworthy negative correlation between the CLO test and esophageal ulcers provides evidence of the differing effects of H. pylori infection on antral-predominant and corpus-predominant gastritis.
- Published
- 2023
- Full Text
- View/download PDF
16. Congenital collagenopathies increased the risk of inguinal hernia developing and repair: analysis from a nationwide population-based cohort study
- Author
-
Hao-Han Chang, Yung-Shun Juan, Ching-Chia Li, Hsiang-Ying Lee, and Jian-Han Chen
- Subjects
Medicine ,Science - Abstract
Abstract Herein, we aimed to explore whether male patients with congenital collagen diseases had a higher risk of inguinal herniation than patients without these diseases. Data were retrospectively collected from the National Health Insurance Research Database of Taiwan. The study cohort included 1,801 male patients diagnosed with congenital collagen diseases based on the ICD-9 CM diagnostic codes; after propensity score matching, the control group comprised 6,493 men without congenital collagen diseases. The primary endpoint was inguinal hernia repair during the observation period. During a median follow-up period of 133.9 months, the risk of inguinal herniation in the collagen group was significantly higher than that in the control group (HR = 2.237, 95% CI 1.646–3.291, p
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.