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20 results on '"Hu, Zhibin"'

3. Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese

Author

Zhang, Ying, Li, Yuanfeng, Wu, Miantao, Cao, Pengbo, Liu, Xiaomin, Ren, Qian, Zhai, Yun, Xie, Bobo, Hu, Yanling, Hu, Zhibin, Bei, Jinxin, Ping, Jie, Liu, Xinyi, Yu, Yinghua, Guo, Bingqian, Lu, Hui, Liu, Guanjun, Zhang, Haitao, Cui, Ying, Mo, Zengnan, Shen, Hongbing, Zeng, Yi-Xin, He, Fuchu, Zhang, Hongxing, and Zhou, Gangqiao

Published
2017
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5. The sex ratio of singleton and twin delivery offspring in assisted reproductive technology in China

Author

Chen, Mengxi, primary, Du, Jiangbo, additional, Zhao, Jing, additional, Lv, Hong, additional, Wang, Yifeng, additional, Chen, XiaoJiao, additional, Zhang, Junqiang, additional, Hu, Lingmin, additional, Jin, Guangfu, additional, Shen, Hongbing, additional, Hu, Zhibin, additional, Xiong, Fang, additional, Chen, Li, additional, and Ling, Xiufeng, additional

Published
2017
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6. Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis

Author

Taylor, Amy E, Lu, Feng, Carslake, David J, Hu, Zhibin, Qian, Yun, Liu, Sijun, Chen, Jiaping, Chen, Hongbin, and Davey Smith, George

Subjects
Adult, Male, China, Alcohol Drinking, Blood Pressure, Brain and Behaviour, Article, Cohort Studies, Sex Factors, Asian People, Risk Factors, Odds Ratio, Humans, Alleles, Triglycerides, Aged, Aldehyde Dehydrogenase, Mitochondrial, Tobacco and Alcohol, Cholesterol, HDL, Aldehyde Dehydrogenase, Mendelian Randomization Analysis, Middle Aged, Logistic Models, Diabetes Mellitus, Type 2, Case-Control Studies, Linear Models, Female
Abstract

Observational studies suggest that moderate alcohol consumption may be protective for cardiovascular disease, but results may be biased by confounding and reverse causality. Mendelian randomization, which uses genetic variants as proxies for exposures, can minimise these biases and therefore strengthen causal inference. Using a genetic variant in the ALDH2 gene associated withalcohol consumption, rs671, we performed a Mendelian randomization analysis in 1,712 diabetes cases and 2,076 controls from Nantong, China. Analyses were performed using linear and logistic regression, stratified by sex and diabetes status. The A allele of rs671 was strongly associated with reduced odds of being an alcohol drinker in all groups, but prevalence of alcohol consumptionamongst females was very low. The A allele was associated with reduced systolic and diastolic blood pressure and decreased total and HDL cholesterol in males. The A allele was also associated with decreased triglyceride levels, but only robustly in diabetic males. There was no strong evidence for associations between rs671 and any outcomes in females. Our results suggest that associations of alcohol consumption with blood pressure and HDL-cholesterol are causal. Alcohol also appeared to have adverse effects on triglyceride levels, although this may be restricted to diabetics.

Published
2015
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8. Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia

Author

Lu, Chuncheng, primary, Wen, Yang, additional, Hu, Weiyue, additional, Lu, Feng, additional, Qin, Yufeng, additional, Wang, Ying, additional, Li, Shilin, additional, Yang, Shuping, additional, Lin, Yuan, additional, Wang, Cheng, additional, Jin, Li, additional, Shen, Hongbing, additional, Sha, Jiahao, additional, Wang, Xinru, additional, Hu, Zhibin, additional, and Xia, Yankai, additional

Published
2016
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10. Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia

Author

Zhou, Ran, primary, Wang, Rong, additional, Qin, Yufeng, additional, Ji, Juan, additional, Xu, Miaofei, additional, Wu, Wei, additional, Chen, Minjian, additional, Wu, Di, additional, Song, Ling, additional, Shen, Hongbing, additional, Sha, Jiahao, additional, Miao, Dengshun, additional, Hu, Zhibin, additional, Xia, Yankai, additional, Lu, Chuncheng, additional, and Wang, Xinru, additional

Published
2015
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11. Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study

Author

Wen, Juan, primary, Song, Ci, additional, Jiang, Deke, additional, Jin, Tianbo, additional, Dai, Juncheng, additional, Zhu, Liguo, additional, An, Jiaze, additional, Liu, Yao, additional, Ma, Shijie, additional, Qin, Na, additional, Liang, Cheng, additional, Chen, Jiaping, additional, Jiang, Yue, additional, Yang, Linlin, additional, Liu, Jibin, additional, Liu, Li, additional, Geng, Tingting, additional, Chen, Chao, additional, Jiang, Jie, additional, Chen, Jianguo, additional, Zhu, Fengcai, additional, Zhu, Yefei, additional, Yu, Long, additional, Shen, Hongbing, additional, Zhai, Xiangjun, additional, Xu, Jianfeng, additional, and Hu, Zhibin, additional

Published
2015
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12. Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN

Author

Ji, Juan, primary, Qin, Yufeng, additional, Ren, Jing, additional, Lu, Chuncheng, additional, Wang, Rong, additional, Dai, Xiuliang, additional, Zhou, Ran, additional, Huang, Zhenyao, additional, Xu, Miaofei, additional, Chen, Minjian, additional, Wu, Wei, additional, Song, Ling, additional, Shen, Hongbing, additional, Hu, Zhibin, additional, Miao, Dengshun, additional, Xia, Yankai, additional, and Wang, Xinru, additional

Published
2015
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13. Evaluation of regulatory genetic variants in POU5F1 and risk of congenital heart disease in Han Chinese

Author

Lin, Yuan, primary, Ding, Chenyue, additional, Zhang, Kai, additional, Ni, Bixian, additional, Da, Min, additional, Hu, Liang, additional, Hu, Yuanli, additional, Xu, Jing, additional, Wang, Xiaowei, additional, Chen, Yijiang, additional, Mo, Xuming, additional, Cui, Yugui, additional, Shen, Hongbing, additional, Sha, Jiahao, additional, Liu, Jiayin, additional, and Hu, Zhibin, additional

Published
2015
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16. Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene

Author

Wang, Qian, primary, Liu, Chao, additional, Tang, Chaoming, additional, Guo, Huiping, additional, Liu, Yujiao, additional, Wang, Lina, additional, Zhao, Haichao, additional, Shang, Yongliang, additional, Wen, Yang, additional, Lin, Yuan, additional, Zhou, Tao, additional, Zhou, Zuomin, additional, Dong, Wen, additional, Hu, Zhibin, additional, Guo, Xuejiang, additional, Sha, Jiahao, additional, and Li, Wei, additional

Published
2015
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20. Systematical analyses of variants in CTCF-binding sites identified a novel lung cancer susceptibility locus among Chinese population.

Author

Zhou, Wen, Sun, Jie, Hu, Zhibin, Shen, Hongbing, Shen, Wei, Liu, Jia, Dai, Juncheng, Jin, Guangfu, Lin, Dongxin, Ma, Hongxia, Zhu, Meng, and Wang, Cheng

Subjects
ZINC-finger proteins, ZINC-finger protein genetics, BINDING sites, LUNG cancer risk factors, HEALTH of Chinese people
Abstract

Genome-wide association studies identified genetic susceptibility variants mostly lie outside of protein-coding regions. It suggested variants located at transcriptional regulatory region should play an important role in cancer carcinogenesis including lung cancer. In the present study, we systematically investigated the associations between the variants in the binding sites of an extensive transcription factor CTCF and lung cancer risk in Chinese population. A two-stage case-control design was conducted to evaluate the variants located at the uniform CTCF ChIP-seq peaks in a Chinese population (2,331 vs 3,077; 1,115 vs 1,346). The ChIP-seq data for CTCF, specified on lung cancer cell line A549, were downloaded from ENCODE database. Imputation was performed to increase the genome coverage in the CTCF binding regions. Three variants in CTCF binding sites were found to associate with lung cancer risk in the first stage. Further replication revealed a novel single nucleotide polymorphism rs60507107 was significantly associated with increased risk of lung cancer in two stages (Additive model: OR = 1.19, 95%CI = 1.11-1.27, P = 6.98 × 10−7). Our results indicate that rs60507107 in the binding site of CTCF is associated with an increased risk of lung cancer. This may further advance our understanding of regulatory DNA sequences in cancer development. [ABSTRACT FROM AUTHOR]

Published
2015
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