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Your search keyword '"Hu, Cheng"' showing total 19 results
Start Over Author "Hu, Cheng" Journal scientific reports
19 results on '"Hu, Cheng"'

2. In-situ twistable bilayer graphene

Author

Hu, Cheng, Wu, Tongyao, Huang, Xinyue, Dong, Yulong, Chen, Jiajun, Zhang, Zhichun, Lyu, Bosai, Ma, Saiqun, Watanabe, Kenji, Taniguchi, Takashi, Xie, Guibai, Li, Xiaojun, Liang, Qi, and Shi, Zhiwen

Published
2022
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8. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes

Author

Peng, Danfeng, primary, Wang, Jie, additional, Zhang, Rong, additional, Jiang, Feng, additional, Tam, Claudia H. T., additional, Jiang, Guozhi, additional, Wang, Tao, additional, Chen, Miao, additional, Yan, Jing, additional, Wang, Shiyun, additional, Yan, Dandan, additional, He, Zhen, additional, Ma, Ronald C. W., additional, Bao, Yuqian, additional, Hu, Cheng, additional, and Jia, Weiping, additional

Published
2017
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11. Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension

Author

Liu, Xin, primary, Hu, Cheng, additional, Bao, Minghui, additional, Li, Jing, additional, Liu, Xiaoyan, additional, Tan, Xuerui, additional, Zhou, Yong, additional, Chen, Yequn, additional, Wu, Shouling, additional, Chen, Shuohua, additional, Zhang, Rong, additional, Jiang, Feng, additional, Jia, Weiping, additional, Wang, Xingyu, additional, Yang, Xinchun, additional, and Cai, Jun, additional

Published
2016
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12. A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals

Author

Zhao, Linjing, primary, Ni, Yan, additional, Ma, Xiaojing, additional, Zhao, Aihua, additional, Bao, Yuqian, additional, Liu, Jiajian, additional, Chen, Tianlu, additional, Xie, Guoxiang, additional, Panee, Jun, additional, Su, Mingming, additional, Yu, Herbert, additional, Wang, Congrong, additional, Hu, Cheng, additional, Jia, Weiping, additional, and Jia, Wei, additional

Published
2016
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15. Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population

Author

Wang, Tao, primary, Ma, Xiaojing, additional, Peng, Danfeng, additional, Zhang, Rong, additional, Sun, Xue, additional, Chen, Miao, additional, Yan, Jing, additional, Wang, Shiyun, additional, Yan, Dandan, additional, He, Zhen, additional, Jiang, Feng, additional, Bao, Yuqian, additional, Hu, Cheng, additional, and Jia, Weiping, additional

Published
2016
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17. A variant of PSMD6 is associated with the therapeutic efficacy of oral antidiabetic drugs in Chinese type 2 diabetes patients

Author

Chen, Miao, primary, Hu, Cheng, additional, Zhang, Rong, additional, Jiang, Feng, additional, Wang, Jie, additional, Peng, Danfeng, additional, Tang, Shanshan, additional, Sun, Xue, additional, Yan, Jing, additional, Wang, Shiyun, additional, Wang, Tao, additional, Bao, Yuqian, additional, and Jia, Weiping, additional

Published
2015
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18. Stiff substrates enhance cultured neuronal network activity

Author

Zhang, Quan-You, primary, Zhang, Yan-Yan, additional, Xie, Jing, additional, Li, Chen-Xu, additional, Chen, Wei-Yi, additional, Liu, Bai-Lin, additional, Wu, Xiao-an, additional, Li, Shu-Na, additional, Huo, Bo, additional, Jiang, Lin-Hua, additional, and Zhao, Hu-Cheng, additional

Published
2014
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19. Stiff substrates enhance cultured neuronal network activity.

Author

Quan-You Zhang, Yan-Yan Zhang, Jing Xie, Chen-Xu Li, Wei-Yi Chen, Bai-Lin Liu, Xiao-an Wu, Shu-Na Li, Bo Huo, Lin-Hua Jiang, and Hu-Cheng Zhao

Subjects
BIOMECHANICS, BIOCHEMICAL substrates, BRANCHING (Botany), CELL imaging, SYNAPTOGENESIS, NERVE tissue proteins
Abstract

isThe mechanical property of extracellular matrix and cell-supporting substrates is known to modulate neuronal growth, differentiation, extension and branching. Here we show that substrate stiffness is an important microenvironmental cue, to which mouse hippocampal neurons respond and integrate into synapse formation and transmission in cultured neuronal network. Hippocampal neurons were cultured on polydimethylsiloxane substrates fabricated to have similar surface properties but a 10-fold difference in Young's modulus. Voltage-gated Ca2+ channel currents determined by patch-clamp recording were greater in neurons on stiff substrates than on soft substrates. Ca2+ oscillations in cultured neuronal network monitored using time-lapse single cell imaging increased in both amplitude and frequency among neurons on stiff substrates. Consistently, synaptic connectivity recorded by paired recording was enhanced between neurons on stiff substrates. Furthermore, spontaneous excitatory postsynaptic activity became greater and more frequent in neurons on stiff substrates. Evoked excitatory transmitter release and excitatory postsynaptic currents also were heightened at synapses between neurons on stiff substrates. Taken together, our results provide compelling evidence to show that substrate stiffness is an important biophysical factor modulating synapse connectivity and transmission in cultured hippocampal neuronal network. Such information is useful in designing instructive scaffolds or supporting substrates for neural tissue engineering. [ABSTRACT FROM AUTHOR]

Published
2014
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