1. Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.
- Author
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Hathout, Yetrib, Liang, Chen, Ogundele, Michael, Xu, Ganggang, Tawalbeh, Shefa, Dang, Utkarsh, Hoffman, Eric, Gordish-Dressman, Heather, Conklin, Laurie, van den Anker, John, Clemens, Paula, Mah, Jean, Henricson, Erik, and McDonald, Craig
- Subjects
Biomarkers ,Blood Proteins ,Case-Control Studies ,Cell Adhesion Molecules ,Child ,Child ,Preschool ,Cross-Sectional Studies ,Extracellular Matrix Proteins ,Glucocorticoids ,Humans ,Muscular Dystrophy ,Duchenne - Abstract
Extensive biomarker discoveries for DMD have occurred in the past 7 years, and a vast array of these biomarkers were confirmed in independent cohorts and across different laboratories. In these previous studies, glucocorticoids and age were two major confounding variables. In this new study, using SomaScan technology and focusing on a subset of young DMD patients who were not yet treated with glucocorticoids, we identified 108 elevated and 70 decreased proteins in DMD relative to age matched healthy controls (p value
- Published
- 2019