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1,071 results on '"Henning A"'

1. From wires to waves, a novel sensor system for in vivo pressure monitoring

Author

Daniel Nilsen Wright, Mark Züchner, Eis Annavini, Manuel J. Escalona, Lena Hammerlund Teige, Lars Geir Whist Tvedt, Andreas Lervik, Henning A. Haga, Thomas Guiho, Ingelin Clausen, Thomas Glott, and Jean-Luc Boulland

Subjects
Piezoresistive pressure sensor, MICS, Implant, Pig model, Wireless, Bluetooth, Medicine, Science
Abstract

Abstract Pressure monitoring in various organs of the body is essential for appropriate diagnostic and therapeutic purposes. In almost all situations, monitoring is performed in a hospital setting. Technological advances not only promise to improve clinical pressure monitoring systems, but also engage toward the development of fully implantable systems in ambulatory patients. Such systems would not only provide longitudinal time monitoring to healthcare personnel, but also to the patient who could adjust their way-of-life in response to the measurements. In the past years, we have developed a new type of piezoresistive pressure sensor system. Different bench tests have demonstrated that it delivers precise and reliable pressure measurements in real-time. The potential of this system was confirmed by a continuous recording in a patient that lasted for almost a day. In the present study, we further characterized the functionality of this sensor system by conducting in vivo implantation experiments in nine female farm pigs. To get a step closer to a fully implantable system, we also adapted two different wireless communication solutions to the sensor system. The communication protocols are based on MICS (Medical Implant Communication System) and BLE (Bluetooth Low Energy) communication. As a proof-of-concept, implantation experiments in nine female pigs demonstrated the functionality of both systems, with a notable technical superiority of the BLE.

Published
2024
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2. Tumor cell identification and classification in esophageal adenocarcinoma specimens by hyperspectral imaging

Author

Marianne Maktabi, Yannis Wichmann, Hannes Köhler, Henning Ahle, Dietmar Lorenz, Michael Bange, Susanne Braun, Ines Gockel, Claire Chalopin, and René Thieme

Subjects
Medicine, Science
Abstract

Abstract Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Histopathological confirmation is a key step in tumor diagnosis. Therefore, simplification in decision-making by discrimination between malignant and non-malignant cells of histological specimens can be provided by combination of new imaging technology and artificial intelligence (AI). In this work, hyperspectral imaging (HSI) data from 95 patients were used to classify three different histopathological features (squamous epithelium cells, esophageal adenocarcinoma (EAC) cells, and tumor stroma cells), based on a multi-layer perceptron with two hidden layers. We achieved an accuracy of 78% for EAC and stroma cells, and 80% for squamous epithelium. HSI combined with machine learning algorithms is a promising and innovative technique, which allows image acquisition beyond Red–Green–Blue (RGB) images. Further method validation and standardization will be necessary, before automated tumor cell identification algorithms can be used in daily clinical practice.

Published
2022
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3. Synchrony and multimodality in the timing of Atlantic salmon smolt migration in two Norwegian fjords

Author

Helge B. Bjerck, Henning A. Urke, Thrond O. Haugen, Jo Arve Alfredsen, John Birger Ulvund, and Torstein Kristensen

Subjects
Medicine, Science
Abstract

Abstract The timing of the smolt migration of Atlantic salmon (Salmo salar) is a phenological trait increasingly important to the fitness of this species. Understanding when and how smolts migrate to the sea is crucial to understanding how salmon populations will be affected by both climate change and the elevated salmon lice concentrations produced by salmon farms. Here, acoustic telemetry was used to monitor the fjord migration of wild post-smolts from four rivers across two fjord systems in western Norway. Smolts began their migration throughout the month of May in all populations. Within-population, the timing of migration was multimodal with peaks in migration determined by the timing of spring floods. As a result, migrations were synchronized across populations with similar hydrology. There was little indication that the timing of migration had an impact on survival from the river mouth to the outer fjord. However, populations with longer fjord migrations experienced lower survival rates and had higher variance in fjord residency times. Explicit consideration of the multimodality inherent to the timing of smolt migration in these populations may help predict when smolts are in the fjord, as these modes seem predictable from available environmental data.

Published
2021
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4. Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimers disease.

Author

Martinelli, Filippo, Heinken, Almut, Henning, Ann-Kristin, Ulmer, Maria, Hensen, Tim, González, Antonio, Arnold, Matthias, Asthana, Sanjay, Budde, Kathrin, Engelman, Corinne, Estaki, Mehrbod, Grabe, Hans-Jörgen, Heston, Margo, Johnson, Sterling, Kastenmüller, Gabi, Martino, Cameron, McDonald, Daniel, Rey, Federico, Kilimann, Ingo, Peters, Olive, Wang, Xiao, Spruth, Eike, Schneider, Anja, Fliessbach, Klaus, Wiltfang, Jens, Hansen, Niels, Glanz, Wenzel, Buerger, Katharina, Janowitz, Daniel, Laske, Christoph, Munk, Matthias, Spottke, Annika, Roy, Nina, Nauck, Matthias, Teipel, Stefan, Kaddurah-Daouk, Rima, Bendlin, Barbara, Hertel, Johannes, Thiele, Ines, and Knight, Rob

Subjects
Alzheimer’s disease, Co-metabolism, Constraint-based modelling, Formate, Host-microbiome, Metabolic modelling, Metabolomics, Microbiome, Pathways, Humans, Alzheimer Disease, Microbiota, Gastrointestinal Microbiome, Genomics, Formates
Abstract

In this study, we aimed to understand the potential role of the gut microbiome in the development of Alzheimers disease (AD). We took a multi-faceted approach to investigate this relationship. Urine metabolomics were examined in individuals with AD and controls, revealing decreased formate and fumarate concentrations in AD. Additionally, we utilised whole-genome sequencing (WGS) data obtained from a separate group of individuals with AD and controls. This information allowed us to create and investigate host-microbiome personalised whole-body metabolic models. Notably, AD individuals displayed diminished formate microbial secretion in these models. Additionally, we identified specific reactions responsible for the production of formate in the host, and interestingly, these reactions were linked to genes that have correlations with AD. This study suggests formate as a possible early AD marker and highlights genetic and microbiome contributions to its production. The reduced formate secretion and its genetic associations point to a complex connection between gut microbiota and AD. This holistic understanding might pave the way for novel diagnostic and therapeutic avenues in AD management.

Published
2024

18. Large-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)

Author

Weber, Andrea, van Hees, Vincent T., Stein, Michael J., Gastell, Sylvia, Steindorf, Karen, Herbolsheimer, Florian, Ostrzinski, Stefan, Pischon, Tobias, Brandes, Mirko, Krist, Lilian, Marschollek, Michael, Greiser, Karin Halina, Nimptsch, Katharina, Brandes, Berit, Jochem, Carmen, Sedlmeier, Anja M., Berger, Klaus, Brenner, Hermann, Buck, Christoph, Castell, Stefanie, Dörr, Marcus, Emmel, Carina, Fischer, Beate, Flexeder, Claudia, Harth, Volker, Hebestreit, Antje, Heise, Jana-Kristin, Holleczek, Bernd, Keil, Thomas, Koch-Gallenkamp, Lena, Lieb, Wolfgang, Meinke-Franze, Claudia, Michels, Karin B., Mikolajczyk, Rafael, Kluttig, Alexander, Obi, Nadia, Peters, Annette, Schmidt, Börge, Schipf, Sabine, Schulze, Matthias B., Teismann, Henning, Waniek, Sabina, Willich, Stefan N., Leitzmann, Michael F., and Baurecht, Hansjörg

Published
2024
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27. Membrane estrogen receptor α signaling modulates the sensitivity to estradiol treatment in a dose- and tissue- dependent manner.

Author

Jiang, Yiwen, Horkeby, Karin, Henning, Petra, Wu, Jianyao, Lawenius, Lina, Engdahl, Cecilia, Gupta, Priti, Movérare-Skrtic, Sofia, Nilsson, Karin H, Levin, Ellis, Ohlsson, Claes, and Lagerquist, Marie K

Subjects
Bone and Bones, Uterus, Animals, Humans, Mice, Estradiol, Estrogen Receptor alpha, Ovariectomy, Signal Transduction, Bone Density, Female, Genetics, Estrogen, Contraception/Reproduction, Aging, Nutrition, Cancer, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being
Abstract

Estradiol (E2) affects both reproductive and non-reproductive tissues, and the sensitivity to different doses of E2 varies between tissues. Membrane estrogen receptor α (mERα)-initiated signaling plays a tissue-specific role in mediating E2 effects, however, it is unclear if mERα signaling modulates E2 sensitivity. To determine this, we treated ovariectomized C451A females, lacking mERα signaling, and wildtype (WT) littermates with physiological (0.05 μg/mouse/day (low); 0.6 μg/mouse/day (medium)) or supraphysiological (6 μg/mouse/day (high)) doses of E2 (17β-estradiol-3-benzoate) for three weeks. Low-dose treatment increased uterus weight in WT, but not C451A mice, while non-reproductive tissues (gonadal fat, thymus, trabecular and cortical bone) were unaffected in both genotypes. Medium-dose treatment increased uterus weight and bone mass and decreased thymus and gonadal fat weights in WT mice. Uterus weight was also increased in C451A mice, but the response was significantly attenuated (- 85%) compared to WT mice, and no effects were triggered in non-reproductive tissues. High-dose treatment effects in thymus and trabecular bone were significantly blunted (- 34% and - 64%, respectively) in C451A compared to WT mice, and responses in cortical bone and gonadal fat were similar between genotypes. Interestingly, the high dose effect in uterus was enhanced (+ 26%) in C451A compared to WT mice. In conclusion, loss of mERα signaling reduces the sensitivity to physiological E2 treatment in both non-reproductive tissues and uterus. Furthermore, the E2 effect after high-dose treatment in uterus is enhanced in the absence of mERα, suggesting a protective effect of mERα signaling in this tissue against supraphysiological E2 levels.

Published
2023

28. Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients

Author

Klussmann, Jens Peter, Grosheva, Maria, Meiser, Peter, Lehmann, Clara, Nagy, Eszter, Szijártó, Valéria, Nagy, Gábor, Konrat, Robert, Flegel, Michael, Holzer, Frank, Groß, Dorothea, Steinmetz, Charlotte, Scherer, Barbara, Gruell, Henning, Schlotz, Maike, Klein, Florian, de Aragão, Paula Aguiar, Morr, Henning, Al Saleh, Helal, Bilstein, Andreas, Russo, Belisa, Müller-Scholtz, Susanne, Acikel, Cengizhan, Sahin, Hacer, Werkhäuser, Nina, Allekotte, Silke, and Mösges, Ralph

Published
2023
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35. Simultaneous bright- and dark-field X-ray microscopy at X-ray free electron lasers

Author

Dresselhaus-Marais, Leora E., Kozioziemski, Bernard, Holstad, Theodor S., Ræder, Trygve Magnus, Seaberg, Matthew, Nam, Daewoong, Kim, Sangsoo, Breckling, Sean, Choi, Sungwook, Chollet, Matthieu, Cook, Philip K., Folsom, Eric, Galtier, Eric, Gonzalez, Arnulfo, Gorkhover, Tais, Guillet, Serge, Haldrup, Kristoffer, Howard, Marylesa, Katagiri, Kento, Kim, Seonghan, Kim, Sunam, Kim, Sungwon, Kim, Hyunjung, Knudsen, Erik Bergbäck, Kuschel, Stephan, Lee, Hae Ja, Lin, Chuanlong, McWilliams, R. Stewart, Nagler, Bob, Nielsen, Martin Meedom, Ozaki, Norimasa, Pal, Dayeeta, Pablo Pedro, Ricardo, Saunders, Alison M., Schoofs, Frank, Sekine, Toshimori, Simons, Hugh, van Driel, Tim, Wang, Bihan, Yang, Wenge, Yildirim, Can, Poulsen, Henning Friis, and Eggert, Jon H.

Published
2023
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