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Your search keyword '"Graves, Martin J"' showing total 8 results
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8 results on '"Graves, Martin J"'

7. Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer

Author

Deen, Surrin S., Priest, Andrew N., McLean, Mary A., Gill, Andrew B., Brodie, Cara, Crawford, Robin, Latimer, John, Baldwin, Peter, Earl, Helena M., Parkinson, Christine, Smith, Sarah, Hodgkin, Charlotte, Patterson, Ilse, Addley, Helen, Freeman, Susan, Moyle, Penny, Jimenez-Linan, Mercedes, Graves, Martin J., Sala, Evis, Brenton, James D., and Gallagher, Ferdia A.

Published
2019
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8. The effect of gadolinium-based contrast agent administration on magnetic resonance fingerprinting-based T1 relaxometry in patients with prostate cancer.

Author

Sushentsev, Nikita, Kaggie, Joshua D., Buonincontri, Guido, Schulte, Rolf F., Graves, Martin J., Gnanapragasam, Vincent J., and Barrett, Tristan

Subjects
CONTRAST media, HUMAN fingerprints, PROSTATE cancer, GADOLINIUM, MAGNETIC resonance imaging
Abstract

Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity to motion. MRF has shown promise in improving the diagnosis of clinically significant prostate cancer but requires further validation as part of a prostate multiparametric (mp) MRI protocol. mpMRI protocol mandates the inclusion of dynamic contrast enhanced (DCE) imaging, known for its significant T1 shortening effect. MRF could be used to measure both pre- and post-contrast T1 values, but its utility must be assessed. In this proof-of-concept study, we sought to evaluate the variation in MRF T1 measurements post gadolinium-based contrast agent (GBCA) injection and the utility of such T1 measurements to differentiate peripheral and transition zone tumours from normal prostatic tissue. We found that the T1 variation in all tissues increased considerably post-GBCA following the expected significant T1 shortening effect, compromising the ability of MRF T1 to identify transition zone lesions. We, therefore, recommend performing MRF T1 prior to DCE imaging to maintain its benefit for improving detection of both peripheral and transition zone lesions while reducing additional scanning time. Demonstrating the effect of GBCA on MRF T1 relaxometry in patients also paves the way for future clinical studies investigating the added value of post-GBCA MRF in PCa, including its dynamic analysis as in DCE-MRF. [ABSTRACT FROM AUTHOR]

Published
2020
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