1. Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer.
- Author
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Spurr, Liam F. and Pitroda, Sean P.
- Subjects
- *
NON-small-cell lung carcinoma , *ANEUPLOIDY , *TREATMENT effectiveness , *GENE amplification - Abstract
Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in patients with non-small cell lung cancer (NSCLC). We identify a dose–response relationship between aneuploidy score and patient outcomes. In two independent NSCLC cohorts (n = 659 patients), we demonstrate a novel association between elevated aneuploidy and non-smoking-associated oncogenic driver mutations. Lastly, we report enrichment of TERT amplification and immune-suppressive phenotypes of highly aneuploid NSCLC. Taken together, our findings emphasize a potentially critical role for tumor aneuploidy in guiding immunotherapy treatment strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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