1. Kallikrein proteoforms and reproductive parameters in stallion are conditioned by climate
- Author
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Renato Lima Senra, Camilo José Ramírez-López, Marcos Jorge Magalhães-Júnior, João Gabriel da Silva Neves, Edvaldo Barros, Bruna Waddington, Simone Eliza Facioni Guimarães, José Domingos Guimarães, and Maria Cristina Baracat-Pereira
- Subjects
Medicine ,Science - Abstract
Abstract Horses are seasonal polyoestrous animals, and the photoperiod is the main factor modulating their reproductive activity. There is no consensus on the andrological and biochemical factors that influence breeding seasonality. To assess the involvement of climate in reproduction, Mangalarga Marchador stallions were monitored over 1 year regarding semen quality and seminal plasma proteome. Here, we show that kallikrein (KLKs) proteoforms in seminal plasma are involved in climate conditioning of reproduction. During the breeding season, greater abundance and different types of KLKs occurred simultaneously to lower sperm motility, greater semen volumes and higher concentrations of glucose and cholesterol. Considering that vasodilation due to activation of the kallikrein-kinin system and the consequent inhibition of the renin-angiotensin system may be associated with lower sperm motility, unravelling the involvement of KLK proteoforms in reproductive seasonality is a priority in horse breeding.
- Published
- 2022
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