7 results on '"Bon-Nyeo Koo"'
Search Results
2. Propofol prevents further prolongation of QT interval during liver transplantation
- Author
-
Seung Hyun Kim, Jae Geun Lee, Hyang Mi Ju, SuYoun Choi, Hyukjin Yang, and Bon-Nyeo Koo
- Subjects
Medicine ,Science - Abstract
Abstract Here, we aimed to compare the effects of two anesthetic methods (desflurane inhalation anesthesia vs. propofol-based total intravenous anesthesia (TIVA)] on corrected QT interval (QTc) values during living donor liver transplantation. Altogether, 120 patients who underwent living donor liver transplantation were randomized to either the desflurane or TIVA group. The primary outcome was intraoperative QTc change. Other electrocardiogram, hemodynamic findings and postoperative outcomes were examined as secondary outcomes. QTc values were prolonged intraoperatively in both groups; however, the change was smaller in the TIVA group than in the desflurane group (PGroup × Time 500 ms in the desflurane group than in the TIVA group (63.3% vs. 28.3%, P
- Published
- 2022
- Full Text
- View/download PDF
3. Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice
- Author
-
So Yeong Cheon, Bon-Nyeo Koo, So Yeon Kim, Eun Hee Kam, Junhyun Nam, and Eun Jung Kim
- Subjects
Medicine ,Science - Abstract
Abstract Postoperative delirium is a common neuropsychiatric syndrome resulting a high postsurgical mortality rate and decline in postdischarge function. Extensive research has been performed on both human and animal delirium-like models due to their clinical significance, focusing on systematic inflammation and consequent neuroinflammation playing a key role in the pathogenesis of postoperative cognitive dysfunctions. Since animal models are widely utilized for pathophysiological study of neuropsychiatric disorders, this study aimed at examining the validity of the scopolamine-induced delirium-like mice model with respect to the neuroinflammatory hypothesis of delirium. Male C57BL/6 mice were treated with intraperitoneal scopolamine (2 mg/kg). Neurobehavioral tests were performed to evaluate the changes in cognitive functions, including learning and memory, and the level of anxiety after surgery or scopolamine treatment. The levels of pro-inflammatory cytokines (IL-1β, IL-18, and TNF-α) and inflammasome components (NLRP3, ASC, and caspase-1) in different brain regions were measured. Gene expression profiles were also examined using whole-genome RNA sequencing analyses to compare gene expression patterns of different mice models. Scopolamine treatment showed significant increase in the level of anxiety and impairments in memory and cognitive function associated with increased level of pro-inflammatory cytokines and NLRP3 inflammasome components. Genetic analysis confirmed the different expression patterns of genes involved in immune response and inflammation and those related with the development of the nervous system in both surgery and scopolamine-induced mice models. The scopolamine-induced delirium-like mice model successfully showed that analogous neuropsychiatric changes coincides with the neuroinflammatory hypothesis for pathogenesis of delirium.
- Published
- 2021
- Full Text
- View/download PDF
4. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS
- Author
-
Seiji Yamamoto, Masashi Muramatsu, Erika Azuma, Masashi Ikutani, Yoshinori Nagai, Hiroshi Sagara, Bon-Nyeo Koo, Satomi Kita, Erin O’Donnell, Tsuyoshi Osawa, Hiroyuki Takahashi, Ken-ichi Takano, Mitsuko Dohmoto, Michiya Sugimori, Isao Usui, Yasuhide Watanabe, Noboru Hatakeyama, Takahiro Iwamoto, Issei Komuro, Kiyoshi Takatsu, Kazuyuki Tobe, Shumpei Niida, Naoyuki Matsuda, Masabumi Shibuya, and Masakiyo Sasahara
- Subjects
Medicine ,Science - Abstract
Abstract Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericytes and the mechanism of their recruitment remain unknown. Here, we show a new source of cerebrovascular pericytes during neurogenesis. In the CNS of embryonic day 10.5 mouse embryos, CD31+F4/80+ hematopoietic lineage cells were observed in the avascular region around the dorsal midline of the developing midbrain. These cells expressed additional macrophage markers such as CD206 and CD11b. Moreover, the CD31+F4/80+ cells phagocytosed apoptotic cells as functionally matured macrophages, adhered to the newly formed subventricular vascular plexus, and then divided into daughter cells. Eventually, these CD31+F4/80+ cells transdifferentiated into NG2/PDGFRβ/desmin-expressing cerebrovascular pericytes, enwrapping and associating with vascular endothelial cells. These data indicate that a subset of cerebrovascular pericytes derive from mature macrophages in the very early phase of CNS vascular development, which in turn are recruited from sites of embryonic hematopoiesis such as the yolk sac by way of blood flow.
- Published
- 2017
- Full Text
- View/download PDF
5. A randomised trial evaluating the effect of intraoperative iron administration
- Author
-
Eun Jung Kim, Young-Soo Jung, Jaewoo Song, Bon Nyeo Koo, and Bora Lee
- Subjects
Adult ,Male ,Blood management ,Anemia ,Iron ,medicine.medical_treatment ,Orthognathic surgery ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Reticulocyte production index ,Article ,Hemoglobins ,Young Adult ,03 medical and health sciences ,Medical research ,0302 clinical medicine ,Reticulocyte Count ,medicine ,Humans ,Infusions, Intravenous ,lcsh:Science ,Saline ,Intraoperative Care ,Multidisciplinary ,Anemia, Iron-Deficiency ,Orthognathic Surgical Procedures ,business.industry ,lcsh:R ,Perioperative ,Iron deficiency ,medicine.disease ,Risk factors ,030220 oncology & carcinogenesis ,Anesthesia ,Ferritins ,Ferric ,Female ,lcsh:Q ,business ,medicine.drug - Abstract
Perioperative anaemia increases postoperative morbidity and mortality, and iron deficiency is anaemia’s most common cause in surgical patients. Preoperative intravenous iron increases postoperative haemoglobin; however, data regarding intraoperative intravenous iron’s effectiveness are inadequate. This study examined intraoperative intravenous iron’s effects on postoperative haemoglobin levels in adults. Fifty-seven healthy subjects (aged 19–40 years) scheduled for bimaxillary orthognathic surgery were assigned randomly to the iron (n = 28) or control (n = 29) groups. The iron group received intravenous ferric derisomaltose (1,000 mg) after anaesthetic induction. The control group received an identical volume of intravenous normal saline. The primary outcome was postoperative haemoglobin level. Secondary outcomes included other postoperative haematologic and iron parameters. Laboratory data were obtained preoperatively and at 1 day, 2 weeks, and 4 weeks postoperatively. Haemoglobin was higher in the iron group 2 weeks postoperatively (12.9 g/dL vs. 12.2 g/dL), but the between-group difference was not significant after adjustment for multiple testing. However, the reticulocyte production index was significantly higher in the iron group 2 weeks postoperatively. Intraoperative intravenous iron maintains postoperative haemoglobin values in patients undergoing bimaxillary orthognathic surgery by increasing haematopoietic function and iron bioavailability and therefore appears to be a useful strategy for blood management.
- Published
- 2020
6. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS
- Author
-
Masakiyo Sasahara, Noboru Hatakeyama, Naoyuki Matsuda, Hiroshi Sagara, Mitsuko Dohmoto, Bon Nyeo Koo, Shumpei Niida, Isao Usui, Erin O'Donnell, Seiji Yamamoto, Yasuhide Watanabe, Kiyoshi Takatsu, Masashi Ikutani, Satomi Kita, Ken-ichi Takano, Erika Azuma, Kazuyuki Tobe, Tsuyoshi Osawa, Michiya Sugimori, Issei Komuro, Yoshinori Nagai, Takahiro Iwamoto, Masabumi Shibuya, Masashi Muramatsu, and Hiroyuki Takahashi
- Subjects
Central Nervous System ,0301 basic medicine ,CD31 ,Science ,Biology ,Article ,Mice ,03 medical and health sciences ,medicine ,Animals ,Macrophage ,Yolk sac ,Mice, Knockout ,Multidisciplinary ,Macrophages ,Neurogenesis ,Mesenchymal stem cell ,Neural crest ,Embryonic stem cell ,Capillaries ,Cell biology ,Phenotype ,030104 developmental biology ,medicine.anatomical_structure ,Cell Tracking ,Cell Transdifferentiation ,Immunology ,Medicine ,Pericytes ,Biomarkers ,Homeostasis - Abstract
Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericytes and the mechanism of their recruitment remain unknown. Here, we show a new source of cerebrovascular pericytes during neurogenesis. In the CNS of embryonic day 10.5 mouse embryos, CD31+F4/80+ hematopoietic lineage cells were observed in the avascular region around the dorsal midline of the developing midbrain. These cells expressed additional macrophage markers such as CD206 and CD11b. Moreover, the CD31+F4/80+ cells phagocytosed apoptotic cells as functionally matured macrophages, adhered to the newly formed subventricular vascular plexus, and then divided into daughter cells. Eventually, these CD31+F4/80+ cells transdifferentiated into NG2/PDGFRβ/desmin-expressing cerebrovascular pericytes, enwrapping and associating with vascular endothelial cells. These data indicate that a subset of cerebrovascular pericytes derive from mature macrophages in the very early phase of CNS vascular development, which in turn are recruited from sites of embryonic hematopoiesis such as the yolk sac by way of blood flow.
- Published
- 2017
7. Cell-penetrating interactomic inhibition of nuclear factor-kappa B in a mouse model of postoperative cognitive dysfunction
- Author
-
Bon Nyeo Koo, Ji-Hyun Jeong, Chun-Chang Ho, Diane Da-Hyun Lee, Eun Jung Kim, So Yeong Cheon, Jeongmin Kim, Sang Won Lee, Seungsoo Chung, and Eun Hee Kam
- Subjects
0301 basic medicine ,Male ,Cell ,Anti-Inflammatory Agents ,lcsh:Medicine ,Inflammation ,Hippocampal formation ,Systemic inflammation ,Bioinformatics ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Postoperative Complications ,medicine ,Animals ,Cognitive Dysfunction ,Cognitive decline ,lcsh:Science ,Mice, Inbred ICR ,Multidisciplinary ,business.industry ,lcsh:R ,Transcription Factor RelA ,medicine.disease ,Pathophysiology ,Recombinant Proteins ,Peripheral ,030104 developmental biology ,medicine.anatomical_structure ,lcsh:Q ,medicine.symptom ,business ,Postoperative cognitive dysfunction ,030217 neurology & neurosurgery - Abstract
Some patients experience impaired cognitive functioning after surgery, a phenomenon referred to as postoperative cognitive dysfunction (POCD). Signs of POCD are closely associated with the development of systemic or hippocampal inflammation. However, the precise pathophysiological mechanisms of prevention/treatment options for POCD still remain unclear. After injury, the transcriptional factor nuclear factor-kappa B (NF-κB) is thought to regulate or stimulate inflammation amplification. Therefore, we designed a cell-penetrating fusion protein called nt-p65-TMD, which inhibits NF-κB p65 activation by translocating into the nucleus. In the present study, we discovered that nt-p65-TMD exerted effects on surgery-induced cognitive impairment in mice. Specifically, nt-p65-TMD exhibited strong immunoregulatory properties that were able to reduce surgery-induced elevations in cerebrovascular integrity impairment, subsequent peripheral immune-cell recruitment, and inflammation amplification, which ultimately lead to cognitive decline. The nt-p65-TMD has the unique ability to regulate and reduce systemic inflammation and inflammation amplification, suggesting a new strategy for preventing development of cognitive decline that occurs in POCD.
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.