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13 results on '"Bejarano P"'

4. Tumor infiltrating lymphocytes (TILs) are a prognosis biomarker in Colombian patients with triple negative breast cancer.

Author

Huertas-Caro, Carlos, Ramírez, Mayra, Rey-Vargas, Laura, Bejarano-Rivera, Lina, Ballen, Diego, Nuñez, Marcela, Mejía, Juan, Sua-Villegas, Luz, Cock-Rada, Alicia, Zabaleta, Jovanny, Sanabria-Salas, María, Serrano-Gomez, Silvia, and Fejerman, Laura

Subjects
Humans, Triple Negative Breast Neoplasms, Lymphocytes, Tumor-Infiltrating, Colombia, Prognosis, Biomarkers, Biomarkers, Tumor
Abstract

Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical-pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95% CI 1.01-2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95% CI 1.00-1.46, OR: 1.28, 1.02-1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients.

Published
2023

6. Long-term hospitalisations in survivors of paediatric solid tumours in France

Author

Bejarano-Quisoboni, Daniel, Pelletier-Fleury, Nathalie, Allodji, Rodrigue S., Fresneau, Brice, Boussac, Majorie, Pacquement, Hélène, Doz, François, Berchery, Delphine, Pluchart, Claire, Bondiau, Piere-Yves, Nys, Julie, Jackson, Angela, Demoor-Goldschmidt, Charlotte, Dumas, Agnes, Thomas-Teinturier, Cécile, Schwartz, Boris, Journy, Neige, Rubino, Carole, Vu-Bezin, Giao, Valteau-Couanet, Dominique, El-Fayech, Chiraz, Dufour, Christelle, Haddy, Nadia, and de Vathaire, Florent

Published
2022
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8. Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib

Author

Rodríguez-Gil, Alfonso, Escamilla-Gómez, Virginia, Nufer, Melanie, Andújar-Sánchez, Félix, Lopes-Ramos, Teresa, Bejarano-García, José Antonio, García-Guerrero, Estefanía, Calderón-Cabrera, Cristina, Caballero-Velázquez, Teresa, García-Calderón, Clara Beatriz, Hernández-Díaz, Paola, Reguera-Ortega, Juan Luis, Rodríguez-Torres, Nancy, Martínez-Cibrián, Nuria, Rodríguez-Barbosa, José Ignacio, Villadiego, Javier, and Pérez-Simón, José Antonio

Published
2022
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9. Interconnected marine habitats form a single continental-scale reef system in South America

Author

Carneiro, Pedro B. M., Ximenes Neto, Antônio R., Jucá-Queiroz, Bruno, Teixeira, Carlos E. P., Feitosa, Caroline V., Barroso, Cristiane X., Matthews-Cascon, Helena, de Morais, Jader O., Freitas, João E. P., Santander-Neto, Jones, de Araújo, Jorge T., Monteiro, Leonardo H. U., Pinheiro, Lidriana S., Braga, Marcus D. A., Cordeiro, Ralf T. S., Rossi, Sergio, Bejarano, Sonia, Salani, Sula, Garcia, Tatiane M., Lotufo, Tito M. C., Smith, Tyler B., Faria, Vicente V., and Soares, Marcelo O.

Published
2022
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