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4. Levosimendan displays anti-inflammatory effects and decreases MPO bioavailability in patients with severe heart failure.

Author

Adam, Matti, Meyer, Sven, Knors, Henning, Klinke, Anna, Radunski, Ulf K, Rudolph, Tanja K, Rudolph, Volker, Spin, Joshua M, Tsao, Philip S, Costard-Jäckle, Angelika, and Baldus, Stephan

Subjects
Leukocytes, Neutrophils, Humans, Inflammation, Nitric Oxide, Hydrazones, Pyridazines, Peroxidase, Anti-Inflammatory Agents, Cardiotonic Agents, Severity of Illness Index, Cell Degranulation, Blood Pressure, Time Factors, Middle Aged, Female, Male, Heart Failure, Biomarkers, Simendan
Abstract

Treatment of decompensated heart failure often includes administration of levosimendan. Myeloperoxidase (MPO) is released during polymorphonuclear neutrophil (PMN) degranulation, and mediates dysregulation of vascular tone in heart failure. We evaluated the effects of levosimendan-treatment on MPO in patients with acute decompensation of chronic heart failure over a one week course. Plasma MPO levels were significantly decreased after levosimendan treatment (from 252.1 ± 31.1 pmol/l at baseline to 215.02 ± 27.96 pmol/l at 6 h, p < 0.05). Ex vivo incubation of whole blood with levosimendan decreased MPO release after PMN-stimulation (8.2 ± 1.4-fold increase at baseline vs. 6.0 ± 1.1-fold increase with levosimendan). MPO levels also significantly correlated with diastolic blood pressure over the time course. In a multivariate linear model, the main contributor to systolic, diastolic and mean blood pressure was level of PMN elastase. MPO contributed only in heparin-treated patients, suggesting a more significant role for endothelial-bound MPO than for circulating MPO or elastase with respect to blood pressure regulation. We here provide the first evidence that levosimendan treatment inhibits MPO release by PMNs in decompensated heart failure patients. This mechanism may regulate endothelial function and vascular tone in heart failure patients.

Published
2015

5. Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis

Author

Mollenhauer, Martin, Mehrkens, Dennis, Klinke, Anna, Lange, Max, Remane, Lisa, Friedrichs, Kai, Braumann, Simon, Geißen, Simon, Simsekyilmaz, Sakine, Nettersheim, Felix S., Lee, Samuel, Peinkofer, Gabriel, Geisler, Anne C., Geis, Bianca, Schwoerer, Alexander P., Carrier, Lucie, Freeman, Bruce A., Dewenter, Matthias, Luo, Xiaojing, El-Armouche, Ali, Wagner, Michael, Adam, Matti, Baldus, Stephan, and Rudolph, Volker

Published
2020
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7. Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain

Author

Boeckel, Jes-Niels, Palapies, Lars, Klotsche, Jens, Zeller, Tanja, von Jeinsen, Beatrice, Perret, Maya F., Kleinhaus, Soeren L., Pieper, Lars, Tzikas, Stergios, Leistner, David, Bickel, Christoph, Stalla, Günter K., Lehnert, Hendrik, Lindahl, Bertil, Wittchen, Hans-Ulrich, Silber, Sigmund, Baldus, Stephan, Maerz, Winfried, Dimmeler, Stefanie, Blankenberg, Stefan, Münzel, Thomas, Zeiher, Andreas M., and Keller, Till

Published
2018
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