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2. Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector.

Author

Bäckman S, Näslund J, Forsman M, and Thelaus J

Subjects
Animals, Ecosystem, Francisella tularensis genetics, Humans, Larva microbiology, Mice, Tularemia genetics, Tularemia microbiology, Water Microbiology, Culicidae microbiology, Francisella tularensis pathogenicity, Insect Vectors microbiology, Tularemia transmission
Abstract

Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica (F. t. holarctica) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent F. t. holarctica strain for 24 hours, were allowed to develop into adults when they were individually homogenized. Approximately 24% of the homogenates tested positive for F. t. DNA in PCR. Mice injected with the mosquito homogenates acquired tularemia within 5 days. This novel finding demonstrates the possibility of transmission of bacteria by adult mosquitoes having acquired the pathogen from their aquatic larval habitats.

Published
2015
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