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Your search keyword '"Andrade, Bruno B."' showing total 19 results
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19 results on '"Andrade, Bruno B."'

3. RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Author

Penn-Nicholson, Adam, Mbandi, Stanley Kimbung, Thompson, Ethan, Mendelsohn, Simon C, Suliman, Sara, Chegou, Novel N, Malherbe, Stephanus T, Darboe, Fatoumatta, Erasmus, Mzwandile, Hanekom, Willem A, Bilek, Nicole, Fisher, Michelle, Kaufmann, Stefan HE, Winter, Jill, Murphy, Melissa, Wood, Robin, Morrow, Carl, Van Rhijn, Ildiko, Moody, Branch, Murray, Megan, Andrade, Bruno B, Sterling, Timothy R, Sutherland, Jayne, Naidoo, Kogieleum, Padayatchi, Nesri, Walzl, Gerhard, Hatherill, Mark, Zak, Daniel, and Scriba, Thomas J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Prevention, Infectious Diseases, HIV/AIDS, Lung, Tuberculosis, Rare Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Infection, Good Health and Well Being, Adolescent, Area Under Curve, Biomarkers, Cohort Studies, Female, HIV Infections, Humans, Male, Mycobacterium tuberculosis, Point-of-Care Systems, Positron-Emission Tomography, Prognosis, RNA, Bacterial, ROC Curve, Real-Time Polymerase Chain Reaction, Sensitivity and Specificity, Adolescent Cohort Study team, GC6-74 Consortium, SATVI Clinical and Laboratory Team, ScreenTB Consortium, AE-TBC Consortium, RePORT Brazil Team, Peruvian Household Contacts Cohort Team, CAPRISA IMPRESS team
Abstract

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature, RISK6, for multiple applications: identifying individuals at risk of incident disease, as a screening test for subclinical or clinical tuberculosis, and for monitoring tuberculosis treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts. Prognostic performance significantly exceeded that of previous signatures discovered in the same cohort. Performance for diagnosing subclinical and clinical disease in HIV-uninfected and HIV-infected persons, assessed by area under the receiver-operating characteristic curve, exceeded 85%. As a screening test for tuberculosis, the sensitivity at 90% specificity met or approached the benchmarks set out in World Health Organization target product profiles for non-sputum-based tests. RISK6 scores correlated with lung immunopathology activity, measured by positron emission tomography, and tracked treatment response, demonstrating utility as treatment response biomarker, while predicting treatment failure prior to treatment initiation. Performance of the test in capillary blood samples collected by finger-prick was noninferior to venous blood collected in PAXgene tubes. These results support incorporation of RISK6 into rapid, capillary blood-based point-of-care PCR devices for prospective assessment in field studies.

Published
2020

8. Differential expression of polyamine biosynthetic pathways in skin lesions and in plasma reveals distinct profiles in diffuse cutaneous leishmaniasis

Author

Malta-Santos, Hayna, França-Costa, Jaqueline, Macedo, Amanda, Queiroz, Artur T. L., Fukutani, Kiyoshi F., Muxel, Sandra Marcia, Khouri, Ricardo, Van Weyenbergh, Johan, Boaventura, Viviane, Barral, Aldina, Costa, Jackson M., Floh, Eny Iochevet Segal, Andrade, Bruno B., Floeter-Winter, Lucile M., and Borges, Valéria M.

Published
2020
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11. Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations

Author

Oliveira-de-Souza, Deivide, Vinhaes, Caian L., Arriaga, Maria B., Kumar, Nathella Pavan, Cubillos-Angulo, Juan M., Shi, Ruiru, Wei, Wang, Yuan, Xing, Zhang, Guolong, Cai, Ying, Barry, III, Clifton E., Via, Laura E., Sher, Alan, Babu, Subash, Mayer-Barber, Katrin D., Nakaya, Helder I., Fukutani, Kiyoshi F., and Andrade, Bruno B.

Published
2019
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12. Author Correction: Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome

Author

Silveira-Mattos, Paulo S., Narendran, Gopalan, Akrami, Kevan, Fukutani, Kiyoshi F., Anbalagan, Selvaraj, Nayak, Kaustuv, Subramanyam, Sudha, Subramani, Rajasekaran, Vinhaes, Caian L., Souza, Deivide Oliveira-de, Antonelli, Lis R., Satagopan, Kumar, Porter, Brian O., Sher, Alan, Swaminathan, Soumya, Sereti, Irini, and Andrade, Bruno B.

Published
2019
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13. Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome

Author

Silveira-Mattos, Paulo S., primary, Narendran, Gopalan, additional, Akrami, Kevan, additional, Fukutani, Kiyoshi F., additional, Anbalagan, Selvaraj, additional, Nayak, Kaustuv, additional, Subramanyam, Sudha, additional, Subramani, Rajasekaran, additional, Vinhaes, Caian L., additional, Souza, Deivide Oliveira-de, additional, Antonelli, Lis R., additional, Satagopan, Kumar, additional, Porter, Brian O., additional, Sher, Alan, additional, Swaminathan, Soumya, additional, Sereti, Irini, additional, and Andrade, Bruno B., additional

Published
2019
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14. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance

Author

Araújo-Santos, Théo, primary, Andrade, Bruno B., additional, Gil-Santana, Leonardo, additional, Luz, Nívea F., additional, dos Santos, Priscila L., additional, de Oliveira, Fabrícia A., additional, Almeida, Meirielly Lima, additional, de Santana Campos, Roseane Nunes, additional, Bozza, Patrícia T., additional, Almeida, Roque P., additional, and Borges, Valeria M., additional

Published
2017
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15. Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications

Author

Prada-Medina, Cesar A., primary, Fukutani, Kiyoshi F., additional, Pavan Kumar, Nathella, additional, Gil-Santana, Leonardo, additional, Babu, Subash, additional, Lichtenstein, Flávio, additional, West, Kim, additional, Sivakumar, Shanmugam, additional, Menon, Pradeep A., additional, Viswanathan, Vijay, additional, Andrade, Bruno B., additional, Nakaya, Helder I., additional, and Kornfeld, Hardy, additional

Published
2017
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17. Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis

Author

Solcà, Manuela S., primary, Andrade, Bruno B., additional, Abbehusen, Melissa Moura Costa, additional, Teixeira, Clarissa R., additional, Khouri, Ricardo, additional, Valenzuela, Jesus G., additional, Kamhawi, Shaden, additional, Bozza, Patrícia Torres, additional, Fraga, Deborah Bittencourt Mothé, additional, Borges, Valeria Matos, additional, Veras, Patrícia Sampaio Tavares, additional, and Brodskyn, Claudia Ida, additional

Published
2016
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18. Author Correction: Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

Author

Silveira-Mattos, Paulo S., Narendran, Gopalan, Akrami, Kevan, Fukutani, Kiyoshi F., Anbalagan, Selvaraj, Nayak, Kaustuv, Subramanyam, Sudha, Subramani, Rajasekaran, Vinhaes, Caian L., Souza, Deivide Oliveira-de, Antonelli, Lis R., Satagopan, Kumar, Porter, Brian O., Sher, Alan, Swaminathan, Soumya, Sereti, Irini, and Andrade, Bruno B.

Abstract

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. [ABSTRACT FROM AUTHOR]

Published
2019
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19. Differential expression of CXCR3 and CCR6 on CD4 + T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

Author

Silveira-Mattos PS, Narendran G, Akrami K, Fukutani KF, Anbalagan S, Nayak K, Subramanyam S, Subramani R, Vinhaes CL, Souza DO, Antonelli LR, Satagopan K, Porter BO, Sher A, Swaminathan S, Sereti I, and Andrade BB

Subjects
Adult, Aged, Anti-Retroviral Agents administration & dosage, Anti-Retroviral Agents adverse effects, Anti-Retroviral Agents immunology, CD4-Positive T-Lymphocytes metabolism, Cohort Studies, Coinfection immunology, Coinfection parasitology, Coinfection virology, Female, HIV Infections drug therapy, HIV Infections parasitology, Humans, Immune Reconstitution Inflammatory Syndrome chemically induced, Immunologic Memory drug effects, Male, Middle Aged, Prospective Studies, Randomized Controlled Trials as Topic, Receptors, CCR6 biosynthesis, Receptors, CCR6 genetics, Receptors, CXCR3 genetics, T-Lymphocyte Subsets drug effects, T-Lymphocyte Subsets immunology, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Pulmonary virology, CD4-Positive T-Lymphocytes immunology, HIV Infections immunology, Immune Reconstitution Inflammatory Syndrome immunology, Receptors, CCR6 immunology, Receptors, CXCR3 biosynthesis, Receptors, CXCR3 immunology, Tuberculosis, Pulmonary immunology
Abstract

Immune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy (ART) initiation. Phenotypic changes in T-cells during TB-IRIS and their relationship with systemic inflammation are not fully understood. In this prospective cohort study, we followed 48 HIV-positive patients with PTB from South India before and after ART initiation, examining T-lymphocyte subsets and inflammatory biomarkers in peripheral blood. Quantification of naïve (CD27 + CD45RO - ) as well as effector memory CD4 + T cells (CD27 - CD45RO + ) at weeks 2-6 after ART initiation could distinguish TB-IRIS from non-IRIS individuals. Additional analyses revealed that ART reconstituted different quantities of CD4 + T lymphocyte subsets with preferential expansion of CXCR3 + CCR6 - cells in TB-IRIS patients. Moreover, there was an expansion and functional restoration of central memory (CD27 + CD45RO + ) CXCR3 + CCR6 - CD4 + lymphocytes and corresponding cytokines, with reduction in CXCR3 - CCR6 + cells after ART initiation only in those who developed TB-IRIS. Together, these observations trace a detailed picture of CD4 + T cell subsets tightly associated with IRIS, which may serve as targets for prophylactic and/or therapeutic interventions in the future.

Published
2019
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