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The objective of this study was to evaluate the impact of dietary zinc supplementation in pre-weaned dairy calves on the phenotypic antimicrobial resistance (AMR) of fecal commensal bacteria. A repository of fecal specimens from a random sample of calves block-randomized into placebo (n = 39) and zinc sulfate (n = 28) groups collected over a zinc supplementation clinical trial at the onset of calf diarrhea, calf diarrheal cure, and the last day of 14 cumulative days of zinc or placebo treatment were analyzed. Antimicrobial susceptibility testing was conducted for Enterococcus spp. (n = 167) and E. coli (n = 44), with one representative isolate of each commensal bacteria tested per sample. Parametric survival interval regression models were constructed to evaluate the association between zinc treatment and phenotypic AMR, with exponentiated accelerated failure time (AFT) coefficients adapted for MIC instead of time representing the degree of change in AMR (MIC Ratio, MR). Findings from our study indicated that zinc supplementation did not significantly alter the MIC in Enterococcus spp. for 13 drugs: gentamicin, vancomycin, ciprofloxacin, erythromycin, penicillin, nitrofurantoin, linezolid, quinupristin/dalfopristin, tylosin tartrate, streptomycin, daptomycin, chloramphenicol, and tigecycline (MR = 0.96-2.94, p > 0.05). In E. coli, zinc supplementation was not associated with resistance to azithromycin (MR = 0.80, p > 0.05) and ceftriaxone (MR = 0.95, p > 0.05). However, a significant reduction in E. coli MIC values was observed for ciprofloxacin (MR = 0.17, 95% CI 0.03-0.97) and nalidixic acid (MR = 0.28, 95% CI 0.15-0.53) for zinc-treated compared to placebo-treated calves. Alongside predictions of MIC values generated from these 17 AFT models, findings from this study corroborate the influence of age and antimicrobial exposure on phenotypic AMR.

Abstract Nosemosis is one of the most devastating diseases of Apis mellifera (Honey bees) caused by the single-celled spore-forming fungi Nosema apis, N. ceranae and N. neumanii, causing a severe loss on the colony vitality and productivity. Fumagillin, a MetAP2 inhibitor, was a certified treatment for controlling nosemosis, nevertheless, due to its deleterious effects on honey bees and humans, it is prohibited. So, searching for novel biological agents with affordable selectivity to target Nosema species infecting Apis mellifera, with nil toxicity to bees and humans is the main objective of this study. Nosema species were isolated from naturally infected honey bees. The methanolic extracts of Acacia nilotica, Elaeis guineensis, and Catharanthus roseus were tested to selectively control the growth of Nosema spp of honeybees. The spores of Nosema species were molecularly and morphologically identified. Among the tested plant extracts, the methanolic extracts (0.1%) of A. nilotica had the most activity towards Nosema spp causing about 37.8 and 32.5% reduction in the spores’ load at 5- and 9-days post-infection, respectively, compared to the untreated control. At 0.1%, the A. nilotica methanolic extract exhibited the highest inhibitory effect for Nosema spores, without any obvious bee mortality. Catharanthus roseus displayed a reduction of spores by 27.02%, with bee mortality rate of 27.02%. At 1% for 5 dpi, the A. nilotica extracts led to 18.18% bee mortality, while the C. roseus extracts resulted in 100% mortality, as revealed from the toxicity and quantification bioassays. So, the extracts of A. nilotica and C. roseus had a significant effect in controlling the N. apis and N. ceranae titer compared to the infected untreated control at both time points. The titer of N. apis and N. ceranae was noticeably decreased by more than 80% and 90%, in response to A. nilotica, compared to the control. From the metabolic profiling by GC–MS analysis, the most frequent active compounds of A. nilotica were 2,4,6-trihy-droxybenzoic acid, 1,2-dihydroxybenzene, myristic acid, and linoleic acid. These compounds were analyzed in silico to assess their binding affinity to the ATP binding protein, methionine aminopeptidase and polar tube protein of Nosema species as target enzymes. The compound 2,4,6-trihydroxybenzoic acid had the lowest energy to bind with ATP binding protein, methionine aminopeptidase and polar tube protein of Nosema, followed by 1,2-dihydroxybenzene and myristic acid, compared to fumagilin. So, from the experimental and molecular docking analysis, the extracts of A. nilotica had the highest activity to attack the cellular growth machinery of Nosema species without an obvious effect to the honeybees, ensuring their prospective promising application.

Abstract In this research, flat disk clay-based ceramic membranes were fabricated and optimized for use in the treatment of wastewater contaminated with dye. The properties of the fabricated membranes were assessed to optimize the fabrication conditions, namely, the firing temperature (1150 °C, 1200 °C, and 1250 °C), soaking time (30 min and 60 min) and zeolite percentage (0%, 10%, and 20%). On the other hand, the rejection of methylene blue dye (MB) and acid fuchsin dye (AF) was studied. The surface of the optimal membrane support was modified using functionalized COOH-carbon nanotubes to increase the dye removal percentage. The fabricated membranes were characterized using FTIR, XRD, and XRF. The optimum membrane support was fabricated at 1150 °C, after 30 min of soaking and with 0% zeolite. The most suitable membrane support was found to be AF, as its rejection percentages reached 42% and 95% without and after surface modification, respectively. The surface of the membrane was examined via SEM, which revealed normally distributed pores. The average pore size of the final membrane was found to be 0.076 micrometers using a mercury porosimeter; thus, the produced membranes can be used in ultrafiltration applications. Finally, the fouling properties showed that the total fouling reached 72.8%, of which only 2.1% was irreversible.

Abstract Rapid development realms of parallel architectures and its heterogeneity have inspired researchers to invent new scheduling strategies to efficiently distribute workloads among these architectures in a way that may lead to better performance. This paper presents a comprehensive study on optimizing resource utilization for large-scale problems by employing architecture-aware scheduling techniques. We conducted a series of experiments to measure the execution times of various architectures with different problem sizes. These experiments have been conducted multiple times to minimize measurement variance. The findings from these experiments are utilized to develop a scheduling strategy that enables faster completion of larger data-parallel problems while maximizing resource utilization. The proposed approach makes performance enhancement with 16.7% for large data size. It has a significant impact on enhancing computational efficiency and reducing costs in high-performance computing environments.

Abstract It is imperative to explore new biocompatible drugs with low toxicity for use in medicinal fields such as fighting tumors. Bovine lactoperoxidase (BLPO) stems from the most important enzymes in the bovine whey that provide a proper pattern for nano-formulation with nanomaterials. LPO is a suitable protein to be coated or adsorbed to alginate modified graphene oxide (GO-SA), which forms the modified GO-SA-LPO hybrid structure. This novel combination provides LPO stability with strong anticancer effects and boosts immunity response. The characterization results obtained from different techniques confirmed a successful LPO adsorption on the GO-SA composite surface. Moreover, nano-formulation of LPO with GO-SA composite exhibited a reduction in its size and overall charge. In addition, the experimental results showed greater LPO activity stability in the modified GO-SA-LPO nanocombination than free LPO after storage for 10 weeks at 4 °C. The in vitro study, a crucial step in the validation of our approach, demonstrated that the modified GO-SA-LPO nanocombination showed a potent anticancer selectivity toward colon cancer cell lines more than GO-SA composite or free form of LPO, which enhanced in a dose-dependent manner with high safety manner against normal cells. The apoptotic effect of this novel nanocombination was confirmed by the greatest variations in the expression of both well-known apoptosis genes (p53 and Bcl-2), severe changes in the cellular morphology, DNA fragmentation, and nuclear staining with fluorescence yellow and orange of the target cancer cells. Also, this superior efficacy of the modified GO-SA-LPO nanocombination was induced by suppressing some pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and necrosis factor-kappa B (NF-ĸB). Our observations presented that the modified nanocombination of LPO may offer a novel remedy for treating colon tumors via induced apoptosis pathway, inflammation reduction, and immune response improvement.

Abstract A successful attempt to produce a multi-function glass shield for attenuating neutrons and gamma rays by reinforcing a silicate glass network with boron and bismuth has been accomplished. A composition of 20SiO2-80Na2O (BSiBi0) was proposed to be used as a host glass network and prepared using the melt/annealing techniques. The low concentration of SiO2 in BSiBi0 was not sufficient to form a stable glass network. Then, the proposed BSiBi0 was modified with 10, 20, 30, and 40 mol% of each of B2O3 and Bi2O3 (BSiBi1, BSiBi2, BSiBi3, and BSiBi4) simultaneously. The structural effects of adding B3+ and Bi3+ were studied through X-ray diffraction, density, and FTIR, which all showed enhancement of glass forming ability, a former role of Bi3+ ions, and crowded the glass network by BO4 units. The derived structural parameters $$-$$ - molar volume, mean silicon – silicon separation, mean boron – boron separation, oxygen packing density, packing density, and number of bridging/non-bridging oxygen $$-$$ - were extensively discussed to explore the impact of B3+ and Bi3+ on the formed network. The richness of the proposed host glass network by B3+ and Bi3+ enhanced its thermal stability. The obtained elastic properties by ultrasonic measurements reflect the increase of the glass rigidity with increasing concentrations of B3+ and Bi3+ ions. The obtained glasses have high visible light transparency and almost complete UV absorption. The measured shielding parameters against two types of neutron energies (total slow and slow) and a wide range of gamma rays’ energies showed a significant improvement in the shielding efficiency of the considered glasses. The total slow neutrons, slow neutrons, and gamma rays’ attenuation abilities were improved by 22.9, 135.5, and 73.8 $$-$$ - 199.5%. High thermal stability, elasticity, visible light transparency, and neutrons and gamma rays’ attenuation performance features give the produced glasses, especially BSiBi4 glass, preference as shielding materials in nuclear fields.

Abstract Organic dyestuff are mostly toxic compounds that pose serious dangers to the environment. Adsorption using low-cost adsorbents is the most favorable method for its economic aspects. Recently, geopolymers have been introduced as an effective adsorbent for dyes and heavy metals. In this investigation, the synthesis of geopolymers from fired brick waste (Homra) was studied with full characterization using X-ray Diffraction, Fourier Transform Infrared Spectroscopy, Brunauer–Emmett–Teller, Energy dispersive X-ray, Scanning electron microscope tests and Transmission electron microscopy. The synthesized nano-Homra geopolymer (NHGP) was then subjected to the removal of one of the most used basic dyes, Methylene Blue (MB). Adsorption optimization was applied using Response surface methodology to study dye adsorption by the synthesized nano-geopolymer. The independent variables studied were: temperature, contact time, and concentration of dye in the elimination process, which were varied in the range of (25–60 ℃), (10–180 min), and (20–300 mg/L) respectively. The results obtained from ANOVA indicated that the maximum removal efficiency of 95% and adsorption capacity of 80.65 mg/g at a temperature of 59 ℃, contact time of 163 min, and an initial concentration of 254 mg/L. The results showed that the data obtained from the adsorption of MB onto NHGP was compatible with the Pseudo second order (R2 = 0.9838) and Langmuir isotherm model (R2 = 0.9882).

Abstract Long term use of Amiodarone (AMIO) is associated with the development of ocular adverse effects. This study investigates the short term effects, and the ameliorative consequence of vitamin E on retinal changes that were associated with administration of AMIO. This is accomplished by investigating both retinal structural and conformational characteristics using Fourier transform infrared spectroscopy (FTIR) and Fundus examination. Three groups of healthy rabbits of both sexes were used; the first group served as control. The second group was orally treated with AMIO (160 mg /kg body weight) in a daily basis for two weeks. The last group orally received AMIO as the second group for two weeks then, oral administration of vitamin E (100 mg/kg body weight) for another two weeks as well. FTIR results revealed significant structural and conformational changes in retinal tissue constituents that include lipids and proteins due to AMIO administration. AMIO treatment was associated with fluctuated changes (increased/decreased) in the band position and bandwidth of NH, OH, and CH bonds. This was concomitant with changes in the percentage of retinal protein constituents in particularly α-helix and Turns. AMIO facilitates the formation of intra-molecular hydrogen bonding and turned retinal lipids to be more disordered structure. In conclusion, the obtained FTIR data together with principal component analysis provide evidence that administration of vitamin E following the treatment with AMIO can ameliorate these retinal changes and, these biophysical changes are too early to be detected by Fundus examination.

Abstract This paper seeks to progress the field of topological photonic crystals (TPC) as a promising tool in face of construction flaws. In particular, the structure can be used as a novel temperature sensor. In this regard, the considered TPC structure comprising two different PC designs named PC1 and PC2. PC1 is designed from a stack of multilayers containing Silicon (Si) and Silicon dioxide (SiO2), while layers of SiO2 and composite layer named hyperbolic metamaterial (HMM) are considered in designing PC2. The HMM layer is engineered using subwavelength layers of Si and Bismuth Germinate, or BGO ( $${\text{Bi}}_{4}{\text{Ge}}_{3}{\text{O}}_{12}$$ Bi 4 Ge 3 O 12 ). The mainstay of our suggested temperature sensor is mainly based on the emergence of some resonant modes inside the transmittance spectrum that provide the stability in the presence of the geometrical changes. Meanwhile, our theoretical framework has been introduced in the vicinity of transfer matrix method (TMM), effective medium theory (EMT) and the thermo-optic characteristics of the considered materials. The numerical findings have extensively introduced the role of some topological parameters such as layers’ thicknesses, filling ratio through HMM layers and the periodicity of HMM on the stability or the topological features of the introduced sensor. Meanwhile, the numerical results reveal that the considered design provides some topological edge states (TESs) of a promising robustness and stability against certain disturbances or geometrical changes in the constituent materials. In addition, our sensing tool offers a relatively high sensitivity of 0.27 nm/°C.

Abstract In this study, a novel gamma-ray radiation sensor has been developed depending on a 1D photonic crystal (1D-PhC). Based on porous silicon (PSi) layer that has been penetrated by a conjugated copolymer (B-co-MP) which consists of BEHP-PPV and MEH-PPV, with a fractional ratio of 60:40. The suggested method for the development of the dosimeter is based on the shift of photonic band-gap to shorter wavelengths, where exposure to gamma-ray radiation at doses ranging from 0 to 20 kGy alters the refractive index of the (B-co-MP) copolymer. The fitted experimental data, the equation of Bruggeman effective medium, and the transfer matrix method (TMM) are the main axes in the framework of the current theoretical approach. The collected data shows that, within the visible range, the suggested sensor's sensitivity (224 nm/RIU) is high and stable over a 0-20 kGy applied-dose range. Also, we compared these results with previous research.

Abstract Wastewater is discharged in large amounts from different industries; thus, wastewater treatment is currently one of the main concerns, advanced oxidation is a promising technique for wastewater treatment. This research aims to synthesize magnetite nanoparticles and study their application in wastewater treatment via adsorption and advanced oxidation processes. Magnetite nanoparticles were synthesized via coprecipitation technique between ferric and ferrous sulfate at a molar ratio of 2:1. The prepared sample was characterized using FTIR, XRD, TEM, BET surface area, zeta potential, VSM, and UV‒visible spectroscopy. XRD confirmed the formation of a single face-centered cubic (FCC) spinel structure of Fe3O4. TEM revealed an average particle size of 29.2 nm and a BET surface area of 70.1 m2 g−1. UV‒visible spectroscopy revealed that the UV–visible peak of the sample was obtained at 410 nm. VSM confirmed the attraction of the sample to a magnet with a magnetization of 60 (emu/g). The removal efficiency of methylene blue was studied using adsorption and advanced oxidation methods. For adsorption, the studied parameters were dye concentration 2–10 ppm, 3–10 pH, and 50:300 mg Fe3O4/L. For advanced oxidation, peroxide was used with nanomagnetite as a catalyst, and the studied parameters were pH 2–11, magnetite dose 20–200 PPM, and peroxide dose 500–2000 PPM. The removal efficiency by adsorption reached 95.11% by adding 50 mg of Fe3O4/L and 10 ppm dye conc at 6.5 pH; on the other hand, in advanced oxidation, it reached 98.5% by adding 110 PPM magnetite and 2000 ppm H2O2 at pH 11. The magnetite nanoparticles were reused for ten cycles of advanced oxidation, for a 10% reduction in removal efficiency at the tenth cycle.

Abstract Wastewater from the food industry is considered harmful to human health and aquatic life, as well as polluting water and soil. This research is centered around finding an affordable and easy physicochemical method for dealing with waste generated by the food industry. To accomplish this goal, a new bio-based flocculant called 4-benzyl-4-(2-oleamidoethylamino-2-oxoethyl) morpholin-4-ium chloride was created using sustainable sources, specifically crude olive pomace oil. Its chemical structure was confirmed using various spectroscopic techniques such as FTIR, 1H-NMR, mass spectra, and 13C-NMR. This new bio-based cationic flocculant was combined with alum to act as a coagulant in the waste treatment process. Also, a study was conducted to determine the optimal conditions for the coagulation-flocculation process parameters, namely, pH and alum dosage, on COD and removal efficiency. The results showed that the optimal conditions for flocculation were achieved at pH 5.8, with 680 mg/L alum and 10 mg/L of commercial flocculant dose compared to only 5 mg/L of a new bio-based cationic flocculant. A comparison was made between the new bio-cationic flocculant and a commercial CTAB one for treating wastewater in the food industry. The study found that the new bio-based cationic flocculant was more effective in reducing the chemical oxygen demand, achieving a reduction of 61.3% compared to 54.6% for using a commercial cationic flocculant. Furthermore, using a new bio-based cationic flocculant costs only 0.49 $/g, which is less than the present cationic flocculant, which costs 0.93 $/g. The adoption of this new flocculant provides a sustainable alternative to existing industrial wastewater treatment processes

Abstract Most of the conditions involving cartilaginous tissues are irreversible and involve degenerative processes. The aim of the present study was to fabricate a biocompatible fibrous and film scaffolds using electrospinning and casting techniques to induce chondrogenic differentiation for possible application in cartilaginous tissue regeneration. Polycaprolactone (PCL) electrospun nanofibrous scaffolds and PCL film were fabricated and incorporated with multi-walled carbon nanotubes (MWCNTs). Thereafter, coating of chondroitin sulfate (CS) on the fibrous and film structures was applied to promote chondrogenic differentiation of human dental pulp stem cells (hDPSCs). First, the morphology, hydrophilicity and mechanical properties of the scaffolds were characterized by scanning electron microscopy (SEM), spectroscopic characterization, water contact angle measurements and tensile strength testing. Subsequently, the effects of the fabricated scaffolds on stimulating the proliferation of human dental pulp stem cells (hDPSCs) and inducing their chondrogenic differentiation were evaluated via electron microscopy, flow cytometry and RT‒PCR. The results of the study demonstrated that the different forms of the fabricated PCL-MWCNTs scaffolds analyzed demonstrated biocompatibility. The nanofilm structures demonstrated a higher rate of cellular proliferation, while the nanofibrous architecture of the scaffolds supported the cellular attachment and differentiation capacity of hDPSCs and was further enhanced with CS addition. In conclusion, the results of the present investigation highlighted the significance of this combination of parameters on the viability, proliferation and chondrogenic differentiation capacity of hDPSCs seeded on PCL-MWCNT scaffolds. This approach may be applied when designing PCL-based scaffolds for future cell-based therapeutic approaches developed for chondrogenic diseases.

Abstract Water quality in land-based fish production can be controlled through either instantaneous water exchange or costly wastewater treatment followed by recirculation. Agricultural-aquaculture integration is an excellent alternative technique for reducing nutrient discharge levels, boosting profitability, and converting fish culture wastewater into valuable products. The current study employed a solar energy system to power two separate IMTA-aquaponics systems (Nutrient Film Technique, NFT, and Floating Raft Systems, FRS) for the cultivation of Nile tilapia, African catfish, thin-lipped grey mullet, freshwater crayfish, freshwater mussels, and a variety of vegetables. Tilapia and catfish were fed exclusively on diets under the IMTA system. All wastewater from tilapia and catfish ponds, both dissolved and solid, flows sequentially to ponds containing other cultivated species. The water then flows through the IMTA system's terminal point to the NFT and FRS systems before returning to the tilapia and catfish ponds, allowing complete control of the nutrient flow throughout this entire circular system. Two 147-day production cycles were concluded. The results from the second production cycle are reported. Total biomass gain for aquatic species in the IMTA system was 736.46 kg, compared to 145.49 kg in the tilapia and 271.01 kg in the catfish monoculture systems. The current IMTA system had a cumulative feed conversion ratio (FCR) of 0.90, while the FCRs for tilapia and catfish were 1.28 and 1.42, respectively. Nile tilapia and catfish consumed 571.90 kg of feed containing 25.70 kg of nitrogen (N) and 9.70 kg of phosphorus (P), reflecting, and gaining 11.41 and 3.93 kg of dietary N and P, representing 44.40 and 40.46% dietary N and P retention, respectively. In the IMTA system, the addition of mullet and prawn as detrivores aquatic animals improves dietary N and P utilization efficiency to 59.06 and 51.19%, respectively, while the addition of mussels as herbivore animals improves dietary N and P utilization efficiency to 65.61 and 54.67%, respectively. Finally, using FRS and NFT as hydroponic systems increased dietary N and P efficiency to 83.51% N and 96.82% P, respectively. This study shows that the IMTA-Aquaponic system, as a bio-integrated food production system, can convert the majority of fish-fed residues into valuable products suitable for desert, rural, and urban areas in impoverished and developing countries.

Abstract Worldwide industrialization has grown at a rapid pace, contaminating water resources, particularly with phenolic pollutants that pose a risk to aquatic systems and human health. The goal of this study is to create an inexpensive magnetic composite that can effectively remove nitrophenol (o-NP) using adsorptive means. In this instance, a nonanyl chitosan (N-Cs) derivative was synthesized and then combined with activated petroleum coke (AP-coke) and magnetic Fe3O4 to boost its adsorbability towards o-NP and to facilitate its separation. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometer (XRD), Vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), and zeta potential were employed to characterize the magnetic composite. The experimental results indicated that the Fe3O4/AP-coke/N-Cs composite possesses a greater affinity toward o-NP with a maximal efficiency reached 88% compared to 22.8, 31.2, and 45.8% for Fe3O4, AP-coke and N-Cs, respectively. The equilibrium adsorption data coincided with the Langmuir, Freundlich, and Temkin isotherm models, with a maximum adsorption capacity of 291.55 mg/g at pH 6, whereas the pseudo second order kinetic model offered the best fit to the experimental data. Besides, the developed adsorbent preserved satisfactory adsorption characteristics after reuse for five successive cycles. The proposed adsorption mechanism involves the H-bonding, π-π interaction, hydrophobic interactions and electron donor-acceptor interactions. These findings hypothesize that the constructed magnetic composite could efficiently remove nitrophenols from polluted water with high performance and ease-separation.

Abstract Multiomics analyses have identified multiple potential biomarkers of the incidence and prevalence of complex diseases. However, it is not known which type of biomarker is optimal for clinical purposes. Here, we make a systematic comparison of 90 million genetic variants, 1453 proteins, and 325 metabolites from 500,000 individuals with complex diseases from the UK Biobank. A machine learning pipeline consisting of data cleaning, data imputation, feature selection, and model training using cross-validation and comparison of the results on holdout test sets showed that proteins were most predictive, followed by metabolites, and genetic variants. Only five proteins per disease resulted in median (min–max) areas under the receiver operating characteristic curves for incidence of 0.79 (0.65–0.86) and 0.84 (0.70–0.91) for prevalence. In summary, our work suggests the potential of predicting complex diseases based on a limited number of proteins. We provide an interactive atlas (macd.shinyapps.io/ShinyApp/) to find genomic, proteomic, or metabolomic biomarkers for different complex diseases.

Abstract The pure conjugated polyarylene azomethine (CPAA) and its nanocomposites (CPAA-TiO2) with different concentrations of TiO2 nanoparticles were successfully prepared by in-situ technique and analyzed by different advanced techniques. XRD has confirmed the structural properties and crystallinity of (CPAA) and nanocomposites. The SEM clearly shows that the (CPAA) is uniform and homogeneous, with tightly connected aggregate layers in shape. However, the amount of TiO2 in the nanocomposites greatly affects their morphology, revealing structural differences and indicating a reaction between (CPAA) and TiO2, especially at a higher concentration of 5% TiO2. A new composite of (CPAA) was introduced and the photocatalytic effect for MB was studied. The removal efficiency of (pure-CPAA) over MB dye under simulated sunlight was 62%. However, (CPAA-TiO2 1%) destroyed 90% of MB dyes. It was discovered that the low band gap of (CPAA-TiO2 1% (2.84 eV)) accelerates high electron–hole recombination, increasing photocatalytic activity.

Abstract Supercapacitors have emerged as highly efficient energy storage devices, relying on electrochemical processes. The performance of these devices can be influenced by several factors, with key considerations including the selection of electrode materials and the type of electrolyte utilized. Transition metal oxide electrodes are commonly used in supercapacitors, as they greatly influence the electrochemical performance of these devices. Nonetheless, ferrites' low energy density poses a limitation. Hence, it is crucial to create electrode materials featuring unique and distinct structures, while also exploring the ideal electrolyte types, to enhance the electrochemical performance of supercapacitors incorporating magnesium ferrites (MF). In this study, we effectively prepared magnesium ferrites (MgFe2O4) supported on activated carbon (AC) derived from orange peels (OP) using a simple hydrothermal method. The resulting blends underwent comprehensive characterization employing various methods, including FTIR, XRD, TEM, SEM, EDX, and mapping analysis. Moreover, the electrochemical performance of MgFe2O4@AC composites was evaluated using GCD and CV techniques. Remarkably, the MF45-AC electrode material showed exceptional electrochemical behavior, demonstrating a specific capacitance of 870 F·g−1 within current density of 1.0 A g−1 and potential windows spanning from 0 to 0.5 V. Additionally, the prepared electrodes displayed exceptional cycling stability, with AC, MF, and MF45-AC retaining 89.6%, 94.2%, and 95.1% of their initial specific capacitance, respectively, even after 5000 cycles. These findings underscore the potential of MF-AC composites as superior electrode materials for supercapacitors. The development of such composites, combined with tailored electrolyte concentrations, holds significant promise for advancing the electrochemical performance and energy density of supercapacitor devices.