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Made available in DSpace on 2019-10-04T12:35:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-02-19 FEDER - COMPETE Program Fundacao para a Ciencia e Tecnologia Project CMDT: Past and present population genetics of the vector Aedes aegypti: a tool for dengue control policies FCT Historically known as the yellow fever mosquito, Aedes aegypti invaded Madeira Island in 2005 and was the vector of the island's first dengue outbreak in 2012. We have studied genetic variation at 16 microsatellites and two mitochondrial DNA genes in temporal samples of Madeira Island, in order to assess the origin of the invasion and the population structure of this mosquito vector. Our results indicated at least two independent colonization events occurred on the island, both having a South American source population. In both scenarios, Venezuela was the most probable origin of these introductions, a result that is in accordance with the socioeconomic relations between this country and Madeira Island. Once introduced, Ae. aegypti has rapidly expanded along the southern coast of the island and reached a maximum effective population size (N-e) in 2012, coincident with the dengue epidemic. After the outbreak, there was a 10-fold reduction in N-e estimates, possibly reflecting the impact of community-based vector control measures implemented during the outbreak. These findings have implications for mosquito surveillance not only for Madeira Island, but also for other European regions where Aedes mosquitoes are expanding. Univ Nova Lisboa, Inst Higiene & Med Trop, Global Hlth & Trop Med, Lisbon, Portugal Univ Estadual Paulista, Inst Biociencias, Dept Parasitol, Botucatu, SP, Brazil Museum Nat Hist Funchal, RAM, Madeira, Portugal Univ Cent Venezuela, Inst Med Trop, Secc Entomol Med, Caracas, Venezuela IP RAM, Dept Saude Planeamento & Adm Geral, Inst Adm Saude & Assuntos Sociais, Funchal, Madeira, Portugal Madeira Reg Govt, Funchal, Madeira, Portugal Hlth & Social Affairs, Funchal, Madeira, Portugal Univ Estadual Paulista, Inst Biociencias, Dept Parasitol, Botucatu, SP, Brazil FEDER - COMPETE Program: PTDC/SAU-EPI/115853/2009 Fundacao para a Ciencia e Tecnologia: PTDC/SAU-EPI/115853/2009 Project CMDT: Past and present population genetics of the vector Aedes aegypti: a tool for dengue control policies: Pest-OE/SAU/LA0018/2011 FCT: SFRH/BD/98873/2013 FCT: SFRH/BPD/72532/2010 : GHTM-UID/Multi/04413/2013