Search

Your search keyword '"Akira Iwase"' showing total 4 results
Start Over Author "Akira Iwase" Journal scientific reports
4 results on '"Akira Iwase"'

1. Predictive factors for massive hemorrhage in women with retained products of conception: a prospective study

Author

Reina Sonehara, Tomoko Nakamura, Akira Iwase, Kazuki Nishida, Sachiko Takikawa, Mayuko Murakami, Sayako Yoshita, Ayako Muraoka, Natsuki Miyake, Natsuki Nakanishi, Satoko Osuka, Maki Goto, and Hiroaki Kajiyama

Subjects
Medicine, Science
Abstract

Abstract Retained products of conception (RPOC) is a common cause of postpartum bleeding, which may be life-threatening; however, no evidence-based guidelines exist to assist in evaluating the risk of massive hemorrhage in women with RPOC. In this prospective study, we aimed to evaluate the predictive factors for massive hemorrhage in women with RPOC. The primary and secondary endpoints were to validate the usefulness of power Doppler color scoring (PDCS) in evaluating hypervascularity and to identify other predictive factors (such as maximum RPOC diameter and serum βhCG and Hb level at first visit), respectively. Among the 51 women with RPOC included in this study, 16 (31.5%) experienced massive hemorrhage during follow-up. None of the women with PDCS 1 or 2 (18) experienced massive hemorrhage, whereas 16 (48.5%) women with PDCS 3 or 4 (33) did. Multiple logistic regression analysis showed that the odds ratio [95% confidence interval] (P value) for PDCS, assisted reproductive technology (ART), and low serum hemoglobin (Hb) levels were 22.39 [2.25 − 3087.92] (P = 0.004), 5.72 [1.28 − 33.29] (P = 0.022), and 4.24 [0.97 − 22.99] (P = 0.056), respectively. Further, the decision tree method identified PDCS, ART, and low serum Hb levels as potential predictive factors for massive hemorrhage. This study identified PDCS as useful predictor of massive hemorrhage in women with RPOC. With additional inclusion of factors such as ART and low serum Hb levels, the risk of massive hemorrhage may be effectively evaluated, leading to better management of women of reproductive age.

Published
2022
Full Text
View/download PDF

2. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

Author

Shinya Toyokuni, Tomoko Nakano, Hiroyuki Tsuda, Akira Iwase, Kenji Imai, Tomomi Kotani, Akio Suzumura, Takafumi Ushida, Taku Nagai, and Fumitaka Kikkawa

Subjects
0301 basic medicine, Lipopolysaccharides, medicine.medical_specialty, Lipopolysaccharide, Offspring, lcsh:Medicine, Amygdala, Neuroprotection, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Fetus, In vivo, Memory, Pregnancy, Internal medicine, medicine, Animals, lcsh:Science, Maze Learning, Social Behavior, Prepulse inhibition, Neuroinflammation, Mice, Inbred ICR, Multidisciplinary, business.industry, lcsh:R, Brain, medicine.disease, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Neuroprotective Agents, chemistry, Maternal Exposure, Prenatal Exposure Delayed Effects, Encephalitis, lcsh:Q, Female, business, 030217 neurology & neurosurgery, Hydrogen
Abstract

The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and microglial activation, in the fetal brain. Short-term memory, sociability and social novelty, and sensorimotor gating were evaluated using the Y-maze, three-chamber, and prepulse inhibition (PPI) tests, respectively, at postnatal 3 or 4 weeks. The number of neurons and oligodendrocytes was also analyzed at postnatal 5 weeks by immunohistochemical analysis. Offspring of the LPS-exposed dams showed deficits in short-term memory and social interaction, following neuronal and oligodendrocytic loss in the amygdala and cortex. Maternal H2 administration markedly attenuated these LPS-induced abnormalities. Moreover, we evaluated the effect of H2 on LPS-induced astrocytic activation, both in vivo and in vitro. The number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H2-administered dams. In primary cultured astrocytes, LPS-induced pro-inflammatory cytokines were attenuated by H2 administration. Overall, these findings indicate that maternal H2 administration exerts neuroprotective effects and ameliorates MIA-induced neurodevelopmental deficits of offspring later in life.

Published
2018

3. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation

Author

Minami Matsui, Keiko Sugimoto, Thomas Gänsewig, Ken Shirasu, Rebecca Lyons, Céline Duc, Kemal Kazan, Akira Iwase, Gordon G. Simpson, Geoffrey J. Barton, Mieko Higuchi-Takeuchi, Kousuke Hanada, and Alexander Sherstnev

Subjects
0106 biological sciences, Gene isoform, Polyadenylation, Arabidopsis, Pseudomonas syringae, Repressor, RNA-binding protein, Biology, Real-Time Polymerase Chain Reaction, 01 natural sciences, Article, 03 medical and health sciences, MRNA polyadenylation, Gene Expression Regulation, Plant, RNA, Messenger, RNA Processing, Post-Transcriptional, Plant Diseases, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Messenger RNA, Multidisciplinary, Arabidopsis Proteins, Reverse Transcriptase Polymerase Chain Reaction, RNA-Binding Proteins, RNA, Plants, Genetically Modified, Molecular biology, Immunity, Innate, Peptide Fragments, Repressor Proteins, RNA, Plant, Reactive Oxygen Species, Flagellin, 010606 plant biology & botany
Abstract

RNA-binding proteins (RBPs) play an important role in plant host-microbe interactions. In this study, we show that the plant RBP known as FPA, which regulates 3'-end mRNA polyadenylation, negatively regulates basal resistance to bacterial pathogen Pseudomonas syringae in Arabidopsis. A custom microarray analysis reveals that flg22, a peptide derived from bacterial flagellins, induces expression of alternatively polyadenylated isoforms of mRNA encoding the defence-related transcriptional repressor ETHYLENE RESPONSE FACTOR 4 (ERF4), which is regulated by FPA. Flg22 induces expression of a novel isoform of ERF4 that lacks the ERF-associated amphiphilic repression (EAR) motif, while FPA inhibits this induction. The EAR-lacking isoform of ERF4 acts as a transcriptional activator in vivo and suppresses the flg22-dependent reactive oxygen species burst. We propose that FPA controls use of proximal polyadenylation sites of ERF4, which quantitatively limit the defence response output.

Published
2013
Full Text
View/download PDF

4. The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation.

Author

Rebecca Lyons, Akira Iwase, Thomas Gänsewig, Sherstnev, Alexander, Céline Duc, Barton, Geoffrey J., Kousuke Hanada, Mieko Higuchi-Takeuchi, Minami Matsui, Keiko Sugimoto, Kazan, Kemal, Simpson, Gordon G., and Ken Shirasu

Subjects
*CARRIER proteins, *PROTEIN microarrays, *PSEUDOMONAS syringae, *ARABIDOPSIS, *FLAGELLIN
Abstract

RNA-binding proteins (RBPs) play an important role in plant host-microbe interactions. In this study, we show that the plant RBP known as FPA, which regulates 3'-endmRNApolyadenylation, negatively regulates basal resistance to bacterial pathogen Pseudomonas syringae in Arabidopsis. A custom microarray analysis reveals that flg22, a peptide derived from bacterial flagellins, induces expression of alternatively polyadenylated isoforms of mRNA encoding the defence-related transcriptional repressor ETHYLENE RESPONSE FACTOR 4 (ERF4), which is regulated by FPA. Flg22 induces expression of a novel isoform of ERF4 that lacks the ERF-associated amphiphilic repression (EAR) motif, while FPA inhibits this induction. The EAR-lacking isoform of ERF4 acts as a transcriptional activator in vivo and suppresses the flg22-dependent reactive oxygen species burst. We propose that FPA controls use of proximal polyadenylation sites of ERF4, which quantitatively limit the defence response output. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results