1. Incidence of COVID-19 infection in hospital workers from March 1, 2020 to May 31, 2021 routinely tested, before and after vaccination with BNT162B2
- Author
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Francesca Larese Filon, Paola De Michieli, Francesca Rui, Corrado Negro, and Federico Ronchese
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Health Personnel ,Vaccine Efficacy ,Nasopharynx ,medicine ,Humans ,BNT162 Vaccine ,Retrospective Studies ,Clinical Trials as Topic ,Multidisciplinary ,business.industry ,SARS-CoV-2 ,Incidence (epidemiology) ,Incidence ,Vaccination ,COVID-19 ,Middle Aged ,Logistic Models ,RNA, Viral ,Female ,business ,Follow-Up Studies - Abstract
Objective To evaluate the incidence of COVID-19 infection in health care workers from the start of COVID-19 pandemic in NE of Italy, to the vaccination with BNT162b2. Materials and methods This was a retrospective cohort study. Health care workers were routinely tested for SARS-CoV-2 infections using real-time polymerase chain reaction tests in nasopharyngeal swabs. Logistic regression was used to calculate incident rate ratios (IRRs) of factors associated to COVID-19. Results A total of 4251 workers were followed-up and an annual incidence of COVID-19 of 13.6% was found. In March 2021 the incidence of infection was 4.88 and 103.55 cases for 100.000 person-days in vaccinated and non-vaccinated workers, respectively, with an adjusted IRRs of 0.05 (95% CI 0.02–0.08). Conclusions Our study evaluated the monthly incidence in health care workers in Trieste hospitals before and after the vaccination finding the protective effect of BNT162B2 vaccine in 95% of health care workers routinely tested.
- Published
- 2021