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Your search keyword '"Blood flow"' showing total 3 results
3 results on '"Blood flow"'

1. Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC).

Author

Shariff, Muhammed, Dobariya, Aksharkumar, Albaghdadi, Obada, Awkal, Jacob, Moussa, Hadi, Reyes, Gabriel, Syed, Mansur, Hart, Robert, Longfellow, Cameron, Douglass, Debra, El Ahmadieh, Tarek Y., Good, Levi B., Jakkamsetti, Vikram, Kathote, Gauri, Angulo, Gus, Ma, Qian, Brown, Ronnie, Dunbar, Misha, Shelton, John M., and Evers, Bret M.

Subjects
*BRACHIOCEPHALIC trunk, *BLOOD flow, *BLOOD pressure, *ARTIFICIAL blood circulation, *HEMODYNAMICS, *CEREBRAL circulation
Abstract

Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or limbs. However, current methods for artificial control of cerebral circulation can abolish pulsatility-dependent vascular signaling or neural network phenomena such as the electrocorticogram even while preserving individual neuronal activity. Thus, we set out to mechanically render cerebral hemodynamics fully regulable to replicate or modify native pig brain perfusion. To this end, blood flow to the head was surgically separated from the systemic circulation and full extracorporeal pulsatile circulatory control (EPCC) was delivered via a modified aorta or brachiocephalic artery. This control relied on a computerized algorithm that maintained, for several hours, blood pressure, flow and pulsatility at near-native values individually measured before EPCC. Continuous electrocorticography and brain depth electrode recordings were used to evaluate brain activity relative to the standard offered by awake human electrocorticography. Under EPCC, this activity remained unaltered or minimally perturbed compared to the native circulation state, as did cerebral oxygenation, pressure, temperature and microscopic structure. Thus, our approach enables the study of neural activity and its circulatory manipulation in independence of most of the rest of the organism. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Cerebral arterial architectonics and CFD simulation in mice with type 1 diabetes mellitus of different duration

Author

D. V. Parshin, G. S. Yan’kova, A. A. Cherevko, A. E. Akulov, and Darya Tur

Subjects
Male, medicine.medical_specialty, Science, 0206 medical engineering, Hemodynamics, 02 engineering and technology, Magnetic resonance angiography, Article, 03 medical and health sciences, Cerebral circulation, Mice, 0302 clinical medicine, Mice, Inbred NOD, Animal disease models, Diabetes mellitus, Internal medicine, medicine.artery, medicine, Animals, Type 1 diabetes, Multidisciplinary, medicine.diagnostic_test, business.industry, Statistics, Brain, Blood flow, Cerebral Arteries, medicine.disease, 020601 biomedical engineering, Disease Models, Animal, Diabetes Mellitus, Type 1, Cerebral blood flow, Cerebrovascular Circulation, Cardiology, Medicine, business, 030217 neurology & neurosurgery, Magnetic Resonance Angiography, Circle of Willis
Abstract

Type 1 diabetes is a chronic autoimmune disease that affects tens of millions of people. Diabetes mellitus is one of the strongest factors in the development of cerebrovascular diseases. In this study we used NOD.CB17 Prkdcscid mice and the pharmacological model of type 1 diabetes mellitus of different duration to study changes in the cerebral vasculature. We used two combined approaches using magnetic resonance angiography both steady and transient CFD blood flow modeling. We identified the influence of type 1 diabetes on the architectonics and hemodynamics of the large blood vessels of the brain as the disease progresses. For the first time, we detected a statistically significant change in angioarchitectonics (the angles between the vessels of the circle of Willis, cross-sections areas of vessels) and hemodynamic (maximum blood flow rate, hydraulic resistance) in animals with diabetes duration of 2 months, that is manifested by the development of asymmetry of cerebral blood flow. The result shows the negative effect of diabetes on cerebral circulation as well as the practicability of CFD modeling. This may be of extensive interest, in pharmacological and preclinical studies.

Published
2020

3. Transcranial optical vascular imaging (TOVI) of cortical hemodynamics in mouse brain

Author

David Israeli, Alon Harmelin, Vyacheslav Kalchenko, and Yuri Kuznetsov

Subjects
Pathology, medicine.medical_specialty, Contrast Media, Hemodynamics, Article, Mice, Cerebral circulation, Speckle pattern, medicine.artery, Color mapping, Animals, Medicine, Multidisciplinary, business.industry, Lasers, Optical Imaging, Brain, Infarction, Middle Cerebral Artery, Blood flow, Cerebral Arteries, Radiography, medicine.anatomical_structure, Cerebral cortex, Cerebrovascular Circulation, Middle cerebral artery, Ketamine, business, Preclinical imaging, Biomedical engineering
Abstract

In vivo imaging of cerebral vasculature and blood flow provides highly valuable information for clinicians as well as researchers. Nevertheless, currently available methods are complex, time-consuming and expensive. Here, we present a novel, minimally invasive method for vascular imaging through the sufficiently transparent intact skull of young mice. Our method combines laser speckle and fluorescent imaging with dynamic color mapping and image fusion. Quickly generated wide-field images present clear visual information on blood flow and perfusion in the cerebral cortex and meninges. The ability of the method to visualize hemodynamic changes is demonstrated by induced occlusion of the middle cerebral artery. The compact and easily operated system comprises of several pieces of standard and affordable laboratory equipment. This simple, robust and inexpensive method may become an important tool for assessment of brain hemodynamics in preclinical studies.

Published
2014

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