1. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model
- Author
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Takafumi Sasaoka, Harutoyo Hirano, Noboru Saeki, Atsuo Yoshino, Shigeto Yamawaki, Toshio Tsuji, Ryuji Nakamura, Masashi Kawamoto, Hiroki Matsubara, Hiroki Hirano, Masao Yoshizumi, and Zu Soh
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Sympathetic Nervous System ,Visual analogue scale ,Pain ,lcsh:Medicine ,Blood Pressure ,Article ,03 medical and health sciences ,Electrocardiography ,0302 clinical medicine ,Vascular Stiffness ,Internal medicine ,medicine ,Numeric Rating Scale ,Humans ,030212 general & internal medicine ,Peripheral Nerves ,Photoplethysmography ,lcsh:Science ,Pain Measurement ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Blood Pressure Determination ,Pain Perception ,Sigmoid function ,Arteries ,Models, Theoretical ,medicine.disease ,Intensity (physics) ,Peripheral ,030104 developmental biology ,Blood pressure ,Cardiology ,Arterial stiffness ,lcsh:Q ,business - Abstract
In clinical practice, subjective pain evaluations, e.g., the visual analogue scale and the numeric rating scale, are generally employed, but these are limited in terms of their ability to detect inaccurate reports, and are unsuitable for use in anesthetized patients or those with dementia. We focused on the peripheral sympathetic nerve activity that responds to pain, and propose a method for evaluating pain sensation, including intensity, sharpness, and dullness, using the arterial stiffness index. In the experiment, electrocardiogram, blood pressure, and photoplethysmograms were obtained, and an arterial viscoelastic model was applied to estimate arterial stiffness. The relationships among the stiffness index, self-reported pain sensation, and electrocutaneous stimuli were examined and modelled. The relationship between the stiffness index and pain sensation could be modelled using a sigmoid function with high determination coefficients, where R2 ≥ 0.88, p, This work was supported by the Center of Innovation Program from Japan Science and Technology Agency., Supplementary information accompanies this paper at https://doi.org/10.1038/s41598-018-21223-1.
- Published
- 2018