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Your search keyword '"Loukas, Alex"' showing total 9 results
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9 results on '"Loukas, Alex"'

1. Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

Author

Weeks, Janis C., primary, Roberts, William M., additional, Leasure, Caitlyn, additional, Suzuki, Brian M., additional, Robinson, Kristin J., additional, Currey, Heather, additional, Wangchuk, Phurpa, additional, Eichenberger, Ramon M., additional, Saxton, Aleen D., additional, Bird, Thomas D., additional, Kraemer, Brian C., additional, Loukas, Alex, additional, Hawdon, John M., additional, Caffrey, Conor R., additional, and Liachko, Nicole F., additional

Published
2018
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2. Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes

Author

Chaiyadet, Sujittra, primary, Krueajampa, Watchara, additional, Hipkaeo, Wiphawi, additional, Plosan, Yada, additional, Piratae, Supawadee, additional, Sotillo, Javier, additional, Smout, Michael, additional, Sripa, Banchob, additional, Brindley, Paul J., additional, Loukas, Alex, additional, and Laha, Thewarach, additional

Published
2017
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5. Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects

Author

Giacomin, Paul, Zakrzewski, Martha, Croese, John, Su, Xiaopei, Sotillo, Javier, McCann, Leisa, Navarro, Severine, Mitreva, Makedonka, Krause, Lutz, Loukas, Alex, Cantacessi, Cinzia, Cantacessi, Cinzia [0000-0001-6863-2950], and Apollo - University of Cambridge Repository

Subjects
Ancylostomatoidea, Glutens, High-Throughput Nucleotide Sequencing, Biodiversity, digestive system, Article, Gastrointestinal Microbiome, Immunomodulation, Celiac Disease, Feces, Hookworm Infections, fluids and secretions, Case-Control Studies, parasitic diseases, Animals, Humans, Metagenome, Metagenomics
Abstract

The intestinal microbiota plays a critical role in the development of the immune system. Recent investigations have highlighted the potential of helminth therapy for treating a range of inflammatory disorders, including celiac disease (CeD); however, the mechanisms by which helminths modulate the immune response of the human host and ameliorate CeD pathology are unknown. In this study, we investigated the potential role of alterations in the human gut microbiota in helminth-mediated suppression of an inflammatory disease. We assessed the qualitative and quantitative changes in the microbiota of human volunteers with CeD prior to and following infection with human hookworms, and following challenge with escalating doses of dietary gluten. Experimental hookworm infection of the trial subjects resulted in maintenance of the composition of the intestinal flora, even after a moderate gluten challenge. Notably, we observed a significant increase in microbial species richness over the course of the trial, which could represent a potential mechanism by which hookworms can regulate gluten-induced inflammation and maintain intestinal immune homeostasis.

Published
2015
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6. Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease

Author

Giacomin, Paul, primary, Zakrzewski, Martha, additional, Jenkins, Timothy P., additional, Su, Xiaopei, additional, Al-Hallaf, Rafid, additional, Croese, John, additional, de Vries, Stefan, additional, Grant, Andrew, additional, Mitreva, Makedonka, additional, Loukas, Alex, additional, Krause, Lutz, additional, and Cantacessi, Cinzia, additional

Published
2016
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9. A genome-wide analysis of annexins from parasitic organisms and their vectors

Author

Cantacessi, Cinzia, primary, Seddon, Jennifer M., additional, Miller, Terrence L., additional, Leow, Chiuan Yee, additional, Thomas, Laëtitia, additional, Mason, Lyndel, additional, Willis, Charlene, additional, Walker, Giselle, additional, Loukas, Alex, additional, Gasser, Robin B., additional, Jones, Malcolm K., additional, and Hofmann, Andreas, additional

Published
2013
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