20 results on '"Guo, Xu"'
Search Results
2. Serum folate associated with nonalcoholic fatty liver disease and advanced hepatic fibrosis
- Author
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Chen, Hao-Kai, Luo, Jing, Li, Xiu-Juan, Liao, Wan-Zhe, Hu, Yu-Qi, and Guo, Xu-Guang
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- 2023
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3. The effectiveness of the puncture channel plugging for reduction of complications after CT-guided percutaneous transthoracic needle biopsy
- Author
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Wang, Dong-xu, Wang, Yu-guang, Ding, Guo-xu, Li, Bo, Liu, Rui-nan, Ai, Zhong-wei, and Wang, Yang
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- 2023
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4. Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
- Author
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Wang, Dong-xu, Zhang, Qing, Wen, Qiu-ting, Ding, Guo-xu, Wang, Yu-guang, Du, Feng-xia, Zhang, Tian-yu, Zheng, Xiao-yang, Cong, Hou-yi, Du, You-li, Sang, Jun-zhi, Wang, Ming-da, and Zhang, Shan-xin
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- 2022
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5. Study on synergistic system of energy-absorbing yielding anti-impact supporting structure and surrounding rock
- Author
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Song, Yimin, Ren, He, Xu, Hailiang, Guo, Xu, Chen, Zheng, and An, Dong
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- 2022
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6. Genome-wide analysis of autophagy-related genes in Medicago truncatula highlights their roles in seed development and response to drought stress
- Author
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Yang, Mingkang, Wang, Liping, Chen, Chumin, Guo, Xu, Lin, Chuanglie, Huang, Wei, and Chen, Liang
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- 2021
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7. The mechanical principles behind the golden ratio distribution of veins in plant leaves
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Sun, Zhi, Cui, Tianchen, Zhu, Yichao, Zhang, Weisheng, Shi, Shanshan, Tang, Shan, Du, Zongliang, Liu, Chang, Cui, Ronghua, Chen, Hongjie, and Guo, Xu
- Published
- 2018
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8. Polyhydroxy cucurbitane triterpenes from Hemsleya penxianensis tubers
- Author
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Zhu Nailiang, Xudong Xu, Jun-Shan Yang, Zhong-Hao Sun, Zhaocui Sun, Xiaowei Huo, Xiaolei Zhou, Meigeng Hu, and Guo-Xu Ma
- Subjects
0301 basic medicine ,Stereochemistry ,Proton Magnetic Resonance Spectroscopy ,Positive control ,lcsh:Medicine ,Medicinal chemistry ,Moths ,Cucurbitane ,Article ,Terpene ,Inhibitory Concentration 50 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Western blot ,Ic50 values ,medicine ,Animals ,Glycosides ,Carbon-13 Magnetic Resonance Spectroscopy ,lcsh:Science ,Multidisciplinary ,Dihydrocucurbitacin F ,medicine.diagnostic_test ,biology ,Structure elucidation ,lcsh:R ,Plutella ,Feeding Behavior ,biology.organism_classification ,Triterpenes ,Biosynthetic Pathways ,Cucurbitaceae ,Plant Tubers ,IκBα ,030104 developmental biology ,chemistry ,Environmental chemistry ,lcsh:Q ,Secondary metabolism ,Solution-state NMR ,030217 neurology & neurosurgery - Abstract
Ten new cucurbitane triterpenoids, hemsleyacins A–J (1–10), together with three known cucurbitane triterpenoids, dihydrocucurbitacin F (11), scandenogenin D (12), and jinfushanencin F (13), were separated from ethanolic tuber extracts of Hemsleya penxianensis. The absolute configurations of the new compounds were established based on NMR, HRESIMS, and CD spectra. Compounds 7 and 10–12 were evaluated in terms of their antifeedant activity against Plutella xylostella larvae. The result showed that compound 10 exhibited potent antifeedant activity against P. xylostella larvae after 48 h of treatment. Furthermore, the MTT test showed that compound 11 exhibited potent inhibition toward the UMUC-3 and T24 cell lines with IC50 values of 29.12 and 35.62 μM, respectively, compared to the positive control cisplatin IC50 values of 8.27 and 13.72 μM. Western blot analysis revealed that compound 11 treatments substantially inhibited the phosphorylation of IκBα.
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- 2019
9. Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells
- Author
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Hua-Guo Xu, Yan-Yan Xu, Rui Jin, and Guo-Ping Zhou
- Subjects
Transcriptional Activation ,0301 basic medicine ,Science ,Response element ,Biology ,Article ,Mice ,03 medical and health sciences ,Transcription (biology) ,Animals ,GATA1 Transcription Factor ,Promoter Regions, Genetic ,Gene ,Gene knockdown ,Multidisciplinary ,General transcription factor ,Membrane Proteins ,Promoter ,GATA1 ,3T3 Cells ,Molecular biology ,Sp3 Transcription Factor ,030104 developmental biology ,Medicine ,Chromatin immunoprecipitation - Abstract
Stimulator of Interferon Gene (STING) is a key mediator of innate immune signaling. STING plays a pivotal role in the pathogenesis of many diseases including infectious diseases, auto-immune diseases and cancer. Many studies have been carried out recently in the field of STING-regulated pathway, however, rarely of transcriptional mechanisms. To characterize the murine STING (mSTING) promoter, we cloned a series of different nucleotide sequences of the 5′-flanking region of the mSTING gene. Transient transfection of promoter-reporter recombinant plasmids and luciferase assay illustrated the region (−77/+177) relative to the transcription start site (TSS) of the mSTING gene was sufficient for full promoter activity. This region contains GATA1, IK2, Sp1/Sp3 and STAT putative transcription factor binding sites. Mutation of GATA1 or Sp1/Sp3 sites led to obvious decrease of the mSTING promoter activity. Overexpression of GATA1 and Sp3 enhanced the mSTING promoter activity, whereas knockdown of GATA1 and Sp3 by a siRNA strategy significantly reduced the transcription activity. Chromatin immunoprecipitation assays demonstrated that GATA1 and Sp3 interact with the mSTING promoter in vivo. These results provided the first analysis of mSTING promoter and demonstrated that transcription factor GATA1 and Sp3 positively regulate the basal transcription of the mSTING gene.
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- 2017
10. TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation
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Hao Xiong, Maojin Liang, Huaili Jiang, Xi Huang, Guo Xu, Yi Liu, Qiuhong Huang, Yu Bin Chen, Zhuohao Li, Yiqing Zheng, Ximing Chen, Zhigang Zhang, Suijun Chen, and Yu Si
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0301 basic medicine ,Adult ,Male ,Osteoclasts ,Matrix metalloproteinase ,Real-Time Polymerase Chain Reaction ,Bone and Bones ,Article ,Proinflammatory cytokine ,03 medical and health sciences ,Mice ,Young Adult ,0302 clinical medicine ,Downregulation and upregulation ,Osteoclast ,medicine ,otorhinolaryngologic diseases ,Animals ,Humans ,Secretion ,Receptors, Immunologic ,Aged ,Multidisciplinary ,Membrane Glycoproteins ,Chemistry ,Middle Aged ,Up-Regulation ,Mice, Inbred C57BL ,Toll-Like Receptor 4 ,TLR2 ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cancer research ,TLR4 ,Cytokines ,Female ,Signal transduction ,Inflammation Mediators ,Signal Transduction - Abstract
Triggering receptor expressed on myeloid cells (TREM) has been broadly studied in inflammatory disease. However, the expression and function of TREM-2 remain undiscovered in acquired cholesteatoma. The expression of TREM-2 was significantly higher in human acquired cholesteatoma than in normal skin from the external auditory canal, and its expression level was positively correlated with the severity of bone destruction. Furthermore, TREM-2 was mainly expressed on dendritic cells (DCs). In human acquired cholesteatoma, the expression of proinflammatory cytokines (IL-1β, TNF-α and IL-6) and matrix metalloproteinases (MMP-2, MMP-8 and MMP-9) were up-regulated, and their expression levels were positively correlated with TREM-2 expression. Osteoclasts were activated in human acquired cholesteatoma. In an animal model, TREM-2 was up-regulated in mice with experimentally acquired cholesteatoma. TREM-2 deficiency impaired the maturation of experimentally acquired cholesteatoma and protected against bone destruction induced by experimentally acquired cholesteatoma. Additional data showed that TREM-2 up-regulated IL-1β and IL-6 expression via TLR4 instead of the TLR2 signaling pathway and promoted MMP-2 and MMP-8 secretion and osteoclast activation in experimentally acquired cholesteatoma. Therefore, TREM-2 might enhance acquired cholesteatoma-induced bone destruction by amplifying the inflammatory response via TLR4 signaling pathways and promoting MMP secretion and osteoclast activation.
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- 2016
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11. TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction
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Yi Liu, Yu Si, Sui Jun Chen, Guo Xu, Hao Xiong, Yi Qing Zheng, Huai Li Jiang, Xiang Liu, Yu Bin Chen, Zhuo Hao Li, Zhigang Zhang, and Qiu Hong Huang
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Adult ,Male ,Adolescent ,medicine.medical_treatment ,Osteoclasts ,Inflammation ,Cell Count ,Biology ,Article ,Bone and Bones ,Pathogenesis ,Young Adult ,Osteoclast ,medicine ,otorhinolaryngologic diseases ,Evoked Potentials, Auditory, Brain Stem ,Animals ,Humans ,Cholesteatoma ,Hearing Loss ,Aged ,Demography ,Multidisciplinary ,Bacteria ,Middle Aged ,medicine.disease ,Up-Regulation ,Mice, Inbred C57BL ,Toll-Like Receptor 4 ,TLR2 ,medicine.anatomical_structure ,Cytokine ,RANKL ,Immunology ,biology.protein ,TLR4 ,Cytokines ,Female ,medicine.symptom ,Inflammation Mediators - Abstract
Acquired cholesteatoma is a chronic inflammatory disease characterized by both hyperkeratinized squamous epithelial overgrowth and bone destruction. Toll-like receptor (TLR) activation and subsequent inflammatory cytokine production are closely associated with inflammatory bone disease. However, the expression and function of TLRs in cholesteatoma remain unclear.We observed inflammatory cell infiltration of the matrix and prematrix of human acquired cholesteatoma, as well as dramatically increased expression of TLR4 and the pro-inflammatory cytokines TNF-α and IL-1β. TLR2 exhibited an up-regulation that was not statistically significant. TLR4 expression in human acquired cholesteatoma correlated with disease severity; the number of TLR4-positive cells increased with an increased degree of cholesteatoma, invasion, bone destruction and hearing loss. Moreover, TLR4 deficiency was protective against experimental acquired cholesteatoma-driven bone destruction and hearing loss, as it reduced local TNF-α and IL-1β expression and impaired osteoclast formation by decreasing expression of the osteoclast effectors receptor activator of nuclear factor (NF)-κB ligand (RANKL) and tartrate-resistant acid phosphatase (TRAP). TLR2 deficiency did not relieve disease severity, inflammatory responses, or osteoclast formation. Moreover, neither TLR2 nor TLR4 deficiency had an effect on antimicrobial peptides, inducible iNOS,BD-2 expression or bacterial clearance. Therefore, TLR4 may promote cholesteatoma-induced bone destruction and deafness by enhancing inflammatory responses and osteoclastogenesis.
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- 2015
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12. Dislocation creation and void nucleation in FCC ductile metals under tensile loading: A general microscopic picture.
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Wei-Wei Pang, Ping Zhang, Guang-Cai Zhang, Ai-Guo Xu, and Xian-Geng Zhao
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NUCLEATION ,NUCLEATING agents ,HETEROGENOUS nucleation ,DISCONTINUOUS precipitation ,FLUCTUATIONS (Physics) - Abstract
Numerous theoretical and experimental efforts have been paid to describe and understand the dislocation and void nucleation processes that are fundamental for dynamic fracture modeling of strained metals. To date an essential physical picture on the self-organized atomic collective motions during dislocation creation, as well as the essential mechanisms for the void nucleation obscured by the extreme diversity in structural configurations around the void nucleation core, is still severely lacking in literature. Here, we depict the origin of dislocation creation and void nucleation during uniaxial high strain rate tensile processes in face-centered-cubic (FCC) ductile metals. We find that the dislocations are created through three distinguished stages: (i) Flattened octahedral structures (FOSs) are randomly activated by thermal fluctuations; (ii) The double-layer defect clusters are formed by self-organized stacking of FOSs on the close-packed plane; (iii) The stacking faults are formed and the Shockley partial dislocations are created from the double-layer defect clusters. Whereas, the void nucleation is shown to follow a two-stage description. We demonstrate that our findings on the origin of dislocation creation and void nucleation are universal for a variety of FCC ductile metals with low stacking fault energies. [ABSTRACT FROM AUTHOR]
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- 2014
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13. The effectiveness of the puncture channel plugging for reduction of complications after CT-guided percutaneous transthoracic needle biopsy
- Author
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Dong-xu Wang, Yu-guang Wang, Guo-xu Ding, Bo Li, Rui-nan Liu, Zhong-wei Ai, and Yang Wang
- Subjects
Medicine ,Science - Abstract
Abstract The effect of plugging the puncture channel with a mixture of hemocoagulase injection on the complications of CT-guided percutaneous transthoracic need biopsy (PTNB) was discussed. The medical records of PTNB were retrospectively studied from June 2017 to May 2022. In the study, the puncture channel of 626 patients were blocked, while remain 681 patients’ were not. The Mantel Haenszel method performed layered analysis and evaluated the correlation of adjusted confounding factors. The Odds Ratio and its 95% confidence interval were calculated using the Woof method. The incidence of high-level pulmonary hemorrhage was significantly reduced in patients with lesions ≤ 2 cm and different needle lengths. Patients with different pleural-needle tip angle and perineedle emphysema were blocked, and the incidence of pneumothorax and thoracic implants was significantly reduced. Through puncture channel plugging, the incidence of pulmonary hemorrhage, pneumothorax and thoracic catheterization of PTNB under CT guidance was reduced.
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- 2023
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14. A New Strategy of Lithography Based on Phase Separation of Polymer Blends.
- Author
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Guo, Xu, Liu, Long, Zhuang, Zhe, Chen, Xin, Ni, Mengyang, Li, Yang, Cui, Yushuang, Zhan, Peng, Yuan, Changsheng, Ge, Haixiong, Wang, Zhenlin, and Chen, Yanfeng
- Subjects
- *
POLYSTYRENE , *POLYMER blends , *NANOFABRICATION , *RAMAN scattering , *LITHOGRAPHY , *PHOTOVOLTAIC effect - Abstract
Herein, we propose a new strategy of maskless lithographic approach to fabricate micro/nano-porous structures by phase separation of polystyrene (PS)/Polyethylene glycol (PEG) immiscible polymer blend. Its simple process only involves a spin coating of polymer blend followed by a development with deionized water rinse to remove PEG moiety, which provides an extremely facile, low-cost, easily accessible nanofabrication method to obtain the porous structures with wafer-scale. By controlling the weight ratio of PS/PEG polymer blend, its concentration and the spin-coating speed, the structural parameters of the porous nanostructure could be effectively tuned. These micro/nano porous structures could be converted into versatile functional nanostructures in combination with follow-up conventional chemical and physical nanofabrication techniques. As demonstrations of perceived potential applications using our developed phase separation lithography, we fabricate wafer-scale pure dielectric (silicon)-based two-dimensional nanostructures with high broadband absorption on silicon wafers due to their great light trapping ability, which could be expected for promising applications in the fields of photovoltaic devices and thermal emitters with very good performances, and Ag nanodot arrays which possess a surface enhanced Raman scattering (SERS) enhancement factor up to 1.64 × 108 with high uniformity across over an entire wafer. [ABSTRACT FROM AUTHOR]
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- 2015
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15. Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach.
- Author
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Dong, Yan, Zhao, Qun, Ma, Xiaoyan, Ma, Guowu, Liu, Caiyun, Chen, Zhuwen, Yu, Liyuan, Liu, Xuefeng, Zhang, Yanguang, Shao, Shujuan, Xiao, Jing, Li, Jia, Zhang, Weimin, Fu, Ming, Dong, Lijia, Yang, Xiandong, Guo, Xu, Xue, Liyan, Fang, Fei, and Zhan, Qimin
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SQUAMOUS cell carcinoma ,CELL lines ,PROTEOMICS ,CELL differentiation ,CARCINOGENESIS ,NEOPLASTIC cell transformation - Abstract
Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and DMBA are key carcinogens in tobacco smoke. In the present study, for the first time we established the cancerous cell line OSCC-BD induced by B(a)P/DMBA mixture and transformed from dysplastic oral leukoplakia cell line DOK. Cell morphology, proliferation ability, migration ability, colony formation, and tumorigenicity were studied and confirmed the malignant characteristics of OSCC-BD cells. We further identified the differential proteins between DOK and OSCC-BD cells by stable isotope dimethyl labeling based quantitative proteomic method, which showed 18 proteins up-regulated and 16 proteins down-regulated with RSD < 8%. Differential proteins are mainly related to cell cycle, cell proliferation, DNA replication, RNA splicing and apoptosis. Abberant binding function, catalysis activity and transportor activity of differential proteins might contribute to the malignant transformation of OLK. Of the 34 identified differential proteins with RSD < 8%, 13 novel cancer-related proteins were reported in the present study. This study might provide a new insight into the mechanism of OLK malignant transformation and the potent biomarkers for early diagnosis, meanwhile further facilitate the application of the quantification proteomics to carcinogenesis research. [ABSTRACT FROM AUTHOR]
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- 2015
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16. SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery.
- Author
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Guo, Xu, Li, Deyang, Chen, Yibing, An, Jiaze, Wang, Kan, Xu, Zhuding, Chen, Zhinan, and Xing, Jinliang
- Subjects
- *
SINGLE nucleotide polymorphisms , *HYPOXIA-inducible factor 1 , *LIVER cancer patients , *LIVER surgery , *TUMOR growth , *METASTASIS - Abstract
Hypoxia-inducible factor 1α (HIF-1α) plays an important role in tumor growth and metastasis. Genetic variations of HIF1A gene have been shown to influence the developing risk and prognosis in many types of human malignancies. However, their association with clinical outcomes of hepatocellular carcinoma (HCC) patients remains unclear. To investigate the predictive role of single nucleotide polymorphisms (SNPs) in HIF1A gene in HCC patients' outcomes, we genotyped three functional SNPs (rs2057482, rs1957757 and rs2301113) in HIF1A gene and assessed their associations with clinicopathological parameters and prognosis of 492 surgical HCC patients. The patients with variant alleles (CT+TT) of SNP rs2057482 had a significantly lower recurrence risk when compared with patients with the CC genotype. In stratified analysis, the protective effect of rs2057482 CT+TT genotype was more evident in patients with adverse strata, compared with patients with favorable strata. Additionally, strong joint predictive effect between rs2057482 genotypes and AFP level, stage or differentiation were observed. Functional assay also indicated the significant effect of rs2057482 on gene expression. In conclusion, SNP rs2057482 in HIF1A gene is significantly associated with clinical outcomes of Chinese HCC patients after surgery, especially in those with aggressive status, which warrants further validation in other patient populations. [ABSTRACT FROM AUTHOR]
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- 2015
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17. Comparison of CT findings and histopathological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients
- Author
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Dong-xu Wang, Qing Zhang, Qiu-ting Wen, Guo-xu Ding, Yu-guang Wang, Feng-xia Du, Tian-yu Zhang, Xiao-yang Zheng, Hou-yi Cong, You-li Du, Jun-zhi Sang, Ming-da Wang, and Shan-xin Zhang
- Subjects
Medicine ,Science - Abstract
Abstract Pulmonary cryptococcosis (PC) is a common fungal infectious disease, and infection can occur in patients with any immune function. To better understand PC, we compared the CT findings and histopathological results in immunocompetent and immunocompromised patients. The clinical data of 68 patients with PC were collected retrospectively and divided into the immunocompetent group and immunocompromised group. The clinical characteristics, CT manifestations and histopathological characteristics of the two groups of patients were compared. Forty-two patients (61.8%) were immunocompetent, and 26 patients (38.2%) were immunocompromised. Compared with immunocompromised patients, 57.14% (24/42) of immunocompetent patients were asymptomatic (p = 0.002). Compared with immunocompetent patients, cough (14/26, 53.9%) and fever (13/26, 50.0%) were the main symptoms in immunocompromised patients (p = 0.044, p = 0.007). Nodular lesions (97.6%, 41/42) were the most common CT type in immunocompetent patients, and the CT characteristic was a single lesion (25/42, 59.5%); the main histopathological type was nodular fibrogranuloma (30/42, 71.4%), and the main histopathological characteristic was inflammatory granuloma (31/42, 73.81%) formed by macrophage phagocytosis of Cryptococcus. Consolidation (15/26, 57.7%) was more common in the CT type of immunocompromised patients. Multiple lesions (24/26, 92.31%), air bronchial signs (19/26, 73.081%) and cavities (9/26, 34.62%) were the main CT characteristics. The mucinous colloid type (19/26, 73.1%) was its main histopathological type, which was mainly characterized by a small amount of surrounding inflammatory cell infiltration (17/26, 65.4%). There were significant differences in the classification and characteristics of CT and pathology between the two groups (p
- Published
- 2022
- Full Text
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18. miR-181a involves in the hippocampus-dependent memory formation via targeting PRKAA1
- Author
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Sun-fu Zhang, Jun-chen Chen, Jing Zhang, and Jian-guo Xu
- Subjects
Medicine ,Science - Abstract
Abstract Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression was observed after conditioned fear conditioning (CFC) and object location task (OLT) training. Selective overexpression or inhibition of miR-181a in the dorsal hippocampus (DH) via the injection of a miR-181a agomir or antagomir enhanced or impaired the CFC- and OLT-dependent memory formation, respectively. Using bioinformatics and luciferase assays, we identified PRKAA1 as a potential target gene of miR-181a. After CFC or OLT training, the expression and activity of PRKAA1 decreased as miR-181a expression increased and was effectively blocked by the miR-181a antagomir. Moreover, microinjection of the PRKAA1 agonist AICAR or inhibitor compound C in the DH reversed the roles of the miR-181a agomir or antagomir in CFC- and OLT-dependent memory formation. In conclusion, this work provides novel evidence describing the role and mechanism of miR-181a in hippocampus-dependent memory formation, which sheds light on the potential regulation of cognition and future treatments for cognitive disorders.
- Published
- 2017
- Full Text
- View/download PDF
19. Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells
- Author
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Yan-Yan Xu, Rui Jin, Guo-Ping Zhou, and Hua-Guo Xu
- Subjects
Medicine ,Science - Abstract
Abstract Stimulator of Interferon Gene (STING) is a key mediator of innate immune signaling. STING plays a pivotal role in the pathogenesis of many diseases including infectious diseases, auto-immune diseases and cancer. Many studies have been carried out recently in the field of STING-regulated pathway, however, rarely of transcriptional mechanisms. To characterize the murine STING (mSTING) promoter, we cloned a series of different nucleotide sequences of the 5′-flanking region of the mSTING gene. Transient transfection of promoter-reporter recombinant plasmids and luciferase assay illustrated the region (−77/+177) relative to the transcription start site (TSS) of the mSTING gene was sufficient for full promoter activity. This region contains GATA1, IK2, Sp1/Sp3 and STAT putative transcription factor binding sites. Mutation of GATA1 or Sp1/Sp3 sites led to obvious decrease of the mSTING promoter activity. Overexpression of GATA1 and Sp3 enhanced the mSTING promoter activity, whereas knockdown of GATA1 and Sp3 by a siRNA strategy significantly reduced the transcription activity. Chromatin immunoprecipitation assays demonstrated that GATA1 and Sp3 interact with the mSTING promoter in vivo. These results provided the first analysis of mSTING promoter and demonstrated that transcription factor GATA1 and Sp3 positively regulate the basal transcription of the mSTING gene.
- Published
- 2017
- Full Text
- View/download PDF
20. 6.2-GHz modulated terahertz light detection using fast terahertz quantum well photodetectors.
- Author
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Li H, Wan WJ, Tan ZY, Fu ZL, Wang HX, Zhou T, Li ZP, Wang C, Guo XG, and Cao JC
- Abstract
The fast detection of terahertz radiation is of great importance for various applications such as fast imaging, high speed communications, and spectroscopy. Most commercial products capable of sensitively responding the terahertz radiation are thermal detectors, i.e., pyroelectric sensors and bolometers. This class of terahertz detectors is normally characterized by low modulation frequency (dozens or hundreds of Hz). Here we demonstrate the first fast semiconductor-based terahertz quantum well photodetectors by carefully designing the device structure and microwave transmission line for high frequency signal extraction. Modulation response bandwidth of gigahertz level is obtained. As an example, the 6.2-GHz modulated terahertz light emitted from a Fabry-Pérot terahertz quantum cascade laser is successfully detected using the fast terahertz quantum well photodetector. In addition to the fast terahertz detection, the technique presented in this work can also be used for optically characterizing the frequency stability of terahertz quantum cascade lasers, heterodyne detections and photomixing applications.
- Published
- 2017
- Full Text
- View/download PDF
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