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Essential inter-sexual differences of the lipid metabolism and bile-creation in the liver tissue cause the necessity of substantial experimental studies of the testosterone influence on the bile lipid composition and ratio of lipid components of liver secretion of individuals of different sexes. So, the aim of the work was the study of the testosterone influence on the lipid composition in bile of male and female rats. For attaining this aim, male (n=7) and female rats (n=4) were every day during five days intramuscularly administered with propionate testosterone (0,7 mg/kg in the recalculation of the preparation volume– 1 ml/kg). After that in acute experiments in vivo, the bile tract was channelled using thiopental sodium as anesthesia (60 mg/kg intra-abdominally). In six samples of liver secretion, collected in three hours by the method of thin-layer chromatography there was determined concentration of phospholipids, cholesterol and its ethers, free fatty acids and triglycerides. In both males and females were registered one-directional reliable changes in three fractions of bile lipids – the increase of phospholipids, free fatty acids, cholesterol ethers concentration. But in females after five days load with testosterone was noticed the decrease of bile triglycerides concentration, whereas in males – it increases by 39,09–48,48 % (рl0,05) comparing with the correspondent control. So, under conditions of the experiment, the hormone influenced the metabolism and transport of bile lipids in rats of both sexes. At that testosterone caused the more increased incoming of lipids to bile channels in males than in females. Mechanisms of testosterone influence on bile lipid components need the further study

Essential inter-sexual differences of the lipid metabolism and bile-creation in the liver tissue cause the necessity of substantial experimental studies of the testosterone influence on the bile lipid composition and ratio of lipid components of liver secretion of individuals of different sexes. So, the aim of the work was the study of the testosterone influence on the lipid composition in bile of male and female rats. For attaining this aim, male (n=7) and female rats (n=4) were every day during five days intramuscularly administered with propionate testosterone (0,7 mg/kg in the recalculation of the preparation volume– 1 ml/kg). After that in acute experiments in vivo, the bile tract was channelled using thiopental sodium as anesthesia (60 mg/kg intra-abdominally). In six samples of liver secretion, collected in three hours by the method of thin-layer chromatography there was determined concentration of phospholipids, cholesterol and its ethers, free fatty acids and triglycerides. In both males and females were registered one-directional reliable changes in three fractions of bile lipids – the increase of phospholipids, free fatty acids, cholesterol ethers concentration. But in females after five days load with testosterone was noticed the decrease of bile triglycerides concentration, whereas in males – it increases by 39,09–48,48 % (р, Проводили гострі досліди на щурах. Використовували наркоз тіопентал натрію в дозі 60 мг/кг внутрішньоочеревно. Здійснювали канюлювання жовчної протоки. Вводили тестостерон пропіонат у дозі 0,7 мг/кг внутрішньом'язово протягом 5-ти днів. Він викликав збільшення концентрації фосфоліпідів, вільних жирних кислот, етерів холестеролу в жовчі. Вміст тригліцеридів зменшував у самиць, а у самців – збільшував