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Your search keyword '"Ivan Nalvarte"' showing total 2 results
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1. Erratum for the Research Article: 'Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis' by G. MacDonald, I. Nalvarte, T. Smirnova, M. Vecchi, N. Aceto, A. Dolemeyer, A. Frei, S. Lienhard, J. Wyckoff, D. Hess, J. Seebacher, J. J. Keusch, H. Gut, D. Salaun, G. Mazzarol, D. Disalvatore, M. Bentires-Alj, P. P. Di Fiore, A. Badache, N. E. Hynes

Author

Mohamed Bentires-Alj, Nancy E. Hynes, Anna Frei, Tatiana Smirnova, Daniel Hess, Jeffrey Wyckoff, Nicola Aceto, Ali Badache, Susanne Lienhard, A. Dolemeyer, P. P. Di Fiore, Maurizio Vecchi, Jeremy J. Keusch, Heinz Gut, Ivan Nalvarte, Davide Disalvatore, Gwen MacDonald, Danièle Salaün, Jan Seebacher, and Giovanni Mazzarol

Subjects
Chemistry, medicine, chemistry.chemical_element, Cell Biology, medicine.disease, Molecular Biology, Biochemistry, Redox, Copper, Metastasis, Cell biology
Abstract

The spelling of an author’s name is corrected.

Published
2014

2. Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

Author

Ivan Nalvarte, Nancy E. Hynes, Daniel Hess, Jan Seebacher, Pier Paolo Di Fiore, Mohamed Bentires-Alj, Danièle Salaün, Ali Badache, Jeffrey Wyckoff, Heinz Gut, Arno Doelemeyer, Jeremy J. Keusch, Gwen MacDonald, Anna Frei, Nicola Aceto, Giovanni Mazzarol, Manuela Vecchi, Davide Disalvatore, Tatiana Smirnova, and Susanne Lienhard

Subjects
Motility, Breast Neoplasms, Mice, SCID, Biochemistry, Nonheme Iron Proteins, Metastasis, Mice, chemistry.chemical_compound, Cell Movement, Mice, Inbred NOD, Superoxides, medicine, Animals, Humans, Neoplasm Metastasis, Molecular Biology, chemistry.chemical_classification, Oxidase test, Reactive oxygen species, Intracellular Signaling Peptides and Proteins, NADPH Oxidases, NADPH Oxidase 1, Cell Biology, medicine.disease, Neoplasm Proteins, chemistry, NOX1, Immunology, Cancer research, Heterografts, Female, Copper, NADP, Neoplasm Transplantation, Nicotinamide adenine dinucleotide phosphate, Intracellular
Abstract

Memo is an evolutionarily conserved protein with a critical role in cell motility. We found that Memo was required for migration and invasion of breast cancer cells in vitro and spontaneous lung metastasis from breast cancer cell xenografts in vivo. Biochemical assays revealed that Memo is a copper dependent redox enzyme that promoted a more oxidized intracellular milieu and stimulated the production of reactive oxygen species (ROS) in cellular structures involved in migration. Memo was also required for the sustained production of the ROS O2- by NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase 1 (NOX1) in breast cancer cells. Memo abundance was increased in >40 of the primary breast tumors tested was correlated with clinical parameters of aggressive disease and was an independent prognostic factor of early distant metastasis.

Published
2014
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