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JMJD8 inhibits STING signaling and reduces antitumor responses.

Autophagy augments the mucus-secreting capacity of goblet cells by reducing ER stress.

Injury-induced hepatocyte reprogramming depends on a proinflammatory cytokine from Kupffer cells.

A fungal surface protein elicits grooming in flies.

Toxoplasma gondii infection confers a migratory phenotype upon macrophages.

A bacterial endopeptidase that generates NOD2 ligands suppresses colitis.

Resident macrophages mediate antigen capture and presentation in allergic airway inflammation in mice.

Plants detect and respond to neighbors with root-produced hormones.

Bacterial stress caused by antibiotics increases a second messenger that directly stimulates host inflammation.

Sphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.

A bacterial metabolite promotes the progression of colorectal cancer.

The restriction of the yeast prion-like protein Whi3 to particular regions of the ER prevents its transmission to daughter cells.

A Legionella virulence factor blocks mitochondrial ADP/ATP exchange in infected cells.

Commensal-derived retinoic acid protects mice against infection by priming the innate defenses of intestinal epithelial cells.

Lysosome-mediated plasma membrane repair promotes antigen internalization by B cells.

STAT3, FOS, and JUN cooperate to establish, maintain, and reactivate inflammatory memory in epidermal stem cells.

The bacterial bile acid metabolite isoalloLCA stimulates the differentiation of T reg cells.

Cancer cells can recycle mitochondrial components through a pathway that does not require autophagosomes.

Commensals promote skin regeneration and wound healing by stimulating IL-1β signaling in keratinocytes.

Monitoring of environmental polyamines controls the dispersal of Vibrio cholerae biofilms.

An antiapoptotic cytoplasmic protein becomes a proapoptotic nuclear protein in diabetes.

SARS-CoV-2 ORF3a prevents autophagosome-lysosome fusion.

ATDC promotes pancreatic cancer progression and chemoresistance by disrupting KEAP1-mediated ubiquitylation of NRF2.

Intestinal microbes exploit host-derived H 2 O 2 for respiration under both normal and inflammatory conditions.

PRL3 enables cells to tolerate acidic pH and promotes metastasis by stimulating TRPML-dependent lysosome exocytosis.

DDIT4 and IFRD1 trigger the inhibition and reactivation of MTORC1 during regenerative repair.

Commensal-derived d -lactate promotes pathogen capture and clearance by Kupffer cells in the liver.

Nutrient stress changes the biogenesis and biological activity of exosomes in cancer cells.

Ca 2+ and ATP signaling control the self-organized, collective behaviors of neutrophils at wound sites.

Dermal adipocytes promote wound healing by recruiting macrophages and transdifferentiating into myofibroblasts.

Two bacterial fermentation products influence lipid metabolism and secretion in the small intestine.

A fungal protease induces allergic inflammation by damaging the lung epithelium.

CDK7 promotes cell proliferation and tissue growth by protecting the transcriptional coactivator Yap from degradation.

Toxin-stimulated immune signaling helps neonatal mice distinguish between harmless skin colonizers and potential pathogens.

Wounding induces cytoprotective mechanisms that make cells more resistant to oxidative damage.

Chronic inflammation causes olfactory stem cells to become quiescent and secrete immunomodulatory cytokines.

Interorganellar cross-talk controls the storage and mobilization of lipids in fruitflies.

The molecules that bacteria use to coordinate virulence-promoting collective behaviors also activate mast cells.

Retinoids protect the skin from infection by inducing the production of an endogenous antimicrobial protein.

Chondrocytes survive constitutive hypoxia by suppressing mitochondrial respiration.

The LCCL domain of cochlin protects hearing by sequestering bacterial pathogens and stimulating innate immune responses.

Inhibiting the accumulation of cholesterol in iPSC-derived neurons prevents the accumulation of both β-amyloid and tau.

Lysosomal signaling enables stem cell differentiation by sequestering the transcription factor Tfe3 in the cytoplasm.

Cell compaction induces epithelial cell elimination by reducing ERK activation.

Endoplasmic reticulum–associated protein degradation suppresses the production of the fasting-associated hepatokine Fgf21.

A cell wall component of mycobacteria stimulates vascularization of granulomas.

An HSV-1 enzyme represses innate immune responses by deamidating the cytosolic DNA sensor cGAS.

Cisplatin-resistant cancer cells are particularly susceptible to starvation-induced death.

Moderate exposure to ultraviolet light stimulates glutamate synthesis in the brain and improves learning and memory.

A Helicobacter pylori exotoxin manipulates host cell metabolism by inducing amino acid starvation and inhibiting mTORC1 signaling.