9 results on '"Zhengmin Qian"'
Search Results
2. Histological types of lung cancer attributable to fine particulate, smoking, and genetic susceptibility
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Xiaojie, Wang, Tingting, Wang, Junjie, Hua, Miao, Cai, Zhengmin, Qian, Chongjian, Wang, Haitao, Li, Stephen Edward, McMillin, Hannah E, Aaron, Chuanbo, Xie, and Hualiang, Lin
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Air Pollutants ,Lung Neoplasms ,Environmental Engineering ,Air Pollution ,Smoking ,Humans ,Environmental Chemistry ,Genetic Predisposition to Disease ,Particulate Matter ,Dust ,Environmental Exposure ,Pollution ,Waste Management and Disposal - Abstract
Fine particulate matter (PMA total of 298,069 participants from the UK Biobank study without lung cancer at baseline were included in this study. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were estimated using multivariable Cox proportional models for the association of lung cancer and its subtypes with PMDuring 10.4 years of follow-up, 1683 incident lung cancer cases were identified. Our analysis found that genetic variants, smoking, and PMGenetic susceptibility, smoking, and PM
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- 2023
3. Exposure to ultrafine particles and childhood obesity: A cross-sectional analysis of the Seven Northeast Cities (SNEC) Study in China
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Qi-Zhen, Wu, Shu-Li, Xu, Ya-Wen, Tan, Zhengmin, Qian, Michael G, Vaughn, Stephen Edward, McMillin, Pengxin, Dong, Shuang-Jian, Qin, Li-Xia, Liang, Li-Zi, Lin, Ru-Qing, Liu, Bo-Yi, Yang, Gongbo, Chen, Wangjian, Zhang, Li-Wen, Hu, Xiao-Wen, Zeng, and Guang-Hui, Dong
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Male ,Air Pollutants ,China ,Pediatric Obesity ,Environmental Engineering ,Environmental Exposure ,Pollution ,Cross-Sectional Studies ,Air Pollution ,Humans ,Environmental Chemistry ,Female ,Particulate Matter ,Cities ,Child ,Waste Management and Disposal - Abstract
Studies on the obesogenic effect of air pollution on children have been mixed and sparse. Moreover, due to insufficient air monitoring, few studies have investigated the role of more tiny but unregulated particles (ambient particles with a diameter of 0.1 μm or less, ultrafine particles).We sought to explore the associations between long-term exposure to ambient ultrafine particles (UFPs) and childhood obesity in Chinese children.In this cross-sectional study, we randomly recruited 47,990 children, aged 6-18 years, from seven cities in Northeastern China between 2012 and 2013. Child age- and sex-specific z-scores for body mass index (BMI Z-score) and weight status were generated using the World Health Organization growth reference. Four-year average concentrations of UFPs and airborne particulates of diameter ≤ 1 μm (PMWe found that UFPs exposure was associated with greater childhood BMI Z-score and a higher likelihood of obesity. Compared with the lowest quartile, higher quartiles of UFPs were associated with greater odds for obesity prevalence in children (i.e., the adjusted OR was 1.25; 95 % CI, 1.12-1.39; 1.43; 95 % CI, 1.27-1.61; and 1.41; 95 % CI, 1.25-1.58 for the second, third, and fourth quartile, respectively). Similar associations were observed for PMLong-term UFPs exposure was associated with a greater likelihood of childhood obesity, and stronger associations on BMI Z-score were observed in boys and children living close to roadways. This study indicates that more attention should be paid to the health effects of UFPs, and routinely monitoring of UFPs should be considered.
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- 2022
4. Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries
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Zengliang Ruan, Fan Wu, Steven E. Rigdon, Lenise A Cummings-Vaughn, Yanbing Chen, Michael G. Vaughn, Yang Zheng, Xiaojie Wang, Shengzhi Sun, Yin Yang, Hualiang Lin, Lingli Zhang, Zhengmin Qian, and Yanfei Guo
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Mixed model ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,Cross-sectional study ,Fine particulate ,business.industry ,Confounding ,Prevalence ,Presbyopia ,Odds ratio ,010501 environmental sciences ,medicine.disease ,01 natural sciences ,Pollution ,Low and middle income countries ,Environmental health ,medicine ,Environmental Chemistry ,business ,Waste Management and Disposal ,0105 earth and related environmental sciences - Abstract
Background Ambient air pollutant directly contacts with the eyes, however, the effect of ambient fine particulate matter (PM2.5) and ozone (O3) on vision impairment, such as presbyopia, has been kept largely unknown. Methods We surveyed a total of 36,620 participants aged 50 years and above in six low- and middle-income countries. Ambient annual concentrations of PM2.5 and O3 for the residential community were estimated using satellite data and chemical transport model. A mixed effects model was utilized to assess the effects of ambient PM2.5 and O3 on presbyopia, as well as their combined effects. Results A total of 13,841 presbyopia cases were identified among the participants with a prevalence rate of 41.17%. For both PM2.5 and O3, we found a J-shaped exposure-response relationship with the threshold being identified at 15 μg/m3 for PM2.5 and 55 μg/m3 for O3. The odds ratio (OR) of presbyopia was 1.15 (95% CI: 1.09, 1.21) for each 10 μg/m3 increase in PM2.5 above 15 μg/m3 and 1.37 (95% CI: 1.23, 1.54) for O3 above 55 μg/m3 after adjusting for various potential confounding factors. There appeared to be a synergistic interaction between ambient PM2.5 and O3 on presbyopia in the additive model, the combined effect was significantly larger than the sum of their individual effects, with a synergistic index of 2.39. Conclusion This study supports that exposures to ambient PM2.5 and O3 might be important risk factors of presbyopia among old adults, and simultaneously exposure to high level of the two pollutants could intensify their individual effects.
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- 2019
5. Differentiating the effects of air pollution on daily mortality counts and years of life lost in six Chinese megacities
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Fei Tian, Jinlei Qi, Zhengmin Qian, Huan Li, Lijun Wang, Chongjian Wang, Sarah Dee Geiger, Stephen Edward McMillin, Peng Yin, Hualiang Lin, and Maigeng Zhou
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Air Pollutants ,China ,Environmental Engineering ,Nitrogen Dioxide ,Myocardial Ischemia ,Environmental Exposure ,Pollution ,Stroke ,Neuroblastoma ,Pulmonary Disease, Chronic Obstructive ,Air Pollution ,Humans ,Environmental Chemistry ,Particulate Matter ,Cities ,Mortality ,Waste Management and Disposal - Abstract
Ambient air pollution has been widely associated with increased mortality and years of life lost (YLL) from various diseases. However, no study has assessed that the effects of air pollution on overall YLL were due to increased number of mortalities or average YLL per death.We first conducted a time-series study from 2013 to 2016, covering six Chinese megacities. Generalized additive models with a Gaussian link were utilized to estimate the associations of fine particulate matter (PMA total of 1,586,741 deaths from non-accidental causes and 21,916,857 YLLs were recorded in the six cities, providing an average of 13.81 daily YLLs per death. Significant effects of PMOur study indicates observed associations between air pollution and YLL might be mainly induced by increasing mortality count, rather than increasing average life lost for each death. More relevant intervention should be performed to reduce the number of deaths due to air pollution.
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- 2022
6. Long-term exposure to urban air pollution and lung cancer mortality: A 12-year cohort study in Northern China
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Xi Chen, Zhipeng Bai, Ke xin Chen, Michael G. Vaughn, Naijun Tang, Luoping Zhang, Feng ju Song, Ya min Liu, Guo hong Jiang, Jia ju Huang, Bao xin Zhao, Edwin Trevathan, Qing Gu, Bin Han, Li wen Zhang, Jie Chen, Guang-Hui Dong, Zhengmin Qian, and Hong jun Mao
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Adult ,Male ,China ,Lung Neoplasms ,Environmental Engineering ,Passive smoking ,Nitrogen Dioxide ,Air pollution ,010501 environmental sciences ,medicine.disease_cause ,complex mixtures ,01 natural sciences ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,Humans ,Sulfur Dioxide ,Environmental Chemistry ,Medicine ,030212 general & internal medicine ,Lung cancer ,Waste Management and Disposal ,Aged ,Retrospective Studies ,0105 earth and related environmental sciences ,Aged, 80 and over ,Air Pollutants ,business.industry ,Proportional hazards model ,Hazard ratio ,Environmental Exposure ,Middle Aged ,medicine.disease ,Pollution ,respiratory tract diseases ,Cohort ,Marital status ,Female ,business ,Cohort study - Abstract
Cohort evidence that links long-term exposures to air pollution and mortality comes largely from the United States and European countries. We investigated the relationship between long-term exposures to particulate matter
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- 2016
7. Pet ownership in utero and in childhood decreases the effects of environmental tobacco smoke exposure on hypertension in children: A large population based cohort study
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Stephen Edward McMillin, Tia Marks, Shu Li Xu, Guang-Hui Dong, Hong Yao Yu, Shao Lin, Li-Wen Hu, Michael S. Bloom, Xiao Wen Zeng, Ru Qing Liu, Zhi Zhou He, Allison A. Appleton, Jia Sun, Yang Zhou, Xiao Sun, Bo-Yi Yang, Dan Feng, Zhengmin Qian, Qi Zhen Wu, and Ai Ping Liu
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Male ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,010501 environmental sciences ,01 natural sciences ,Tobacco smoke ,Cohort Studies ,Dogs ,Environmental health ,Animals ,Humans ,Environmental Chemistry ,Medicine ,Cities ,Child ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Environmental tobacco smoke exposure ,business.industry ,Ownership ,Environmental Exposure ,Pets ,Odds ratio ,Pollution ,Confidence interval ,Pet ownership ,Blood pressure ,In utero ,Hypertension ,Female ,Tobacco Smoke Pollution ,business ,Cohort study - Abstract
Background Little is known about whether exposure to pets influences the association between hypertension and environmental tobacco smoke (ETS). The current study aims to examine the interaction of pet ownership on ETS exposure and the development of hypertension in children. Methods From 2012 to 2013, a total of 9354 children, 5 to 17 years of age, were recruited from 62 schools in seven northeastern cities. BP in children was measured and hypertension was defined as an average diastolic blood pressure (DBP) or systolic blood pressure (SBP) at or above the 95th percentile for that child's age, sex, and height. Pet ownership in three different time periods (in utero, past 2 years, and currently) and ETS exposure data were collected from parents via a questionnaire. Two-level regressions were used for the data analyses. Results The data show consistent, significant interactions between exposure to pets and effects from ETS. Children who were not exposed to pets experienced stronger effects from ETS on hypertension when compared to those exposed to pets, and the protective effect of pet ownership became stronger with a greater number of pets in the home. Exposure to in utero ETS was associated with hypertension [adjusted odds ratio (aOR) = 1.32, 95% confidence interval (CI): 1.13–1.54] only for those children without pet exposure in utero but not for those with pets (aOR = 0.75; 95% CI: 0.49–1.15) (pinteraction Conclusion This study indicates an inverse relationship between pet ownership and ETS, potentially pointing to pet ownership as protecting against the development of hypertension in children.
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- 2020
8. Maternal air pollution exposure associated with risk of congenital heart defect in pre-pregnancy overweighted women
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Leslie Hinyard, Zhengmin Qian, Hualiang Lin, Qingmei Lin, Zengliang Ruan, Shiyu Zhang, Xiaoling Guo, Bipin Kumar Acharya, Yin Liang, Stephen Edward McMillin, Jia Sun, Changke Wang, Haibo Ge, Yin Yang, and Xueli Wu
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Heart Defects, Congenital ,China ,medicine.medical_specialty ,Environmental Engineering ,010504 meteorology & atmospheric sciences ,Air pollution exposure ,Population ,Heart defect ,010501 environmental sciences ,Overweight ,01 natural sciences ,Cohort Studies ,Pregnancy ,Air Pollution ,medicine ,Humans ,Environmental Chemistry ,education ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Air Pollutants ,education.field_of_study ,business.industry ,Pre pregnancy ,Obstetrics ,Confounding ,Infant, Newborn ,medicine.disease ,Pollution ,Increased risk ,Maternal Exposure ,Female ,Particulate Matter ,medicine.symptom ,business - Abstract
Objectives Prenatal exposure to air pollutant has been associated with congenital heart defect (CHD). However, no study has investigated this effect in pre-pregnancy overweighted women. This study aimed to evaluate gestational exposure to particulate pollutant (PM2.5) and gaseous air pollutants (O3 and NO2) on the risk of CHD, and explore the potential effect modifiers including maternal age, pre-pregnancy BMI and pregestational diseases. Methods In this birth cohort study, a total of 63,213 pregnant women in Foshan, China were initially recruited and followed from their first hospital visit for pregnancy to delivery during 2015–2019. CHD cases were confirmed by the records in hospital- and population- based birth defect surveillance systems. Air pollutant exposures were estimated by the daily concentrations measured in air monitoring stations in each participant's residential county. Mixed-effects regression models, adjusted for potential confounding factors were applied to estimate the associations between air pollutant and CHD during the first three months of the pregnancy. Results A total of 985 (1.6%) newborns were identified as CHD cases. For each 10 μg/m3 increase in ambient O3 during the 1st month, the OR values for CHD were 1.03 (95% CI: 0.94, 1.13) in pre-pregnancy normal weighted women and 1.24 (95% CI: 1.01, 1.53) in pre-pregnancy overweighted women. For each 10 μg/m3 increase in NO2 during the 3rd month, the OR values for CHD were 1.09 (95% CI: 1.01, 1.18) in pre-pregnancy normal weighted women and 1.27 (95% CI: 1.07, 1.51) in pre-pregnancy overweighted women. No significant associations were found between PM2.5 exposure and CHD in our analysis. Conclusions This study demonstrates that gaseous air pollutants (O3 and NO2) exposure during the cardiac embryogenesis period is associated with an increased risk of CHD, particularly for pre-pregnancy overweighted women.
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- 2020
9. Association of polyfluoroalkyl chemical exposure with serum lipids in children
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Zhengmin Qian, Brett Emo, Xiao Wen Zeng, Yu Zhu, Michael G. Vaughn, Jia Bao, Yungling Leo Lee, Xiao Di Qin, Jie Li, and Guang-Hui Dong
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Male ,medicine.medical_specialty ,Environmental Engineering ,Blood lipids ,Perfluorononanoic acid ,Chemical exposure ,chemistry.chemical_compound ,Total cholesterol ,Internal medicine ,medicine ,Humans ,Environmental Chemistry ,Perfluorooctane sulfonic acid ,Child ,Waste Management and Disposal ,Fluorocarbons ,Chemistry ,Environmental Exposure ,Lipids ,Pollution ,Endocrinology ,Alkanesulfonic Acids ,Quartile ,Child, Preschool ,Environmental chemistry ,Perfluorooctanoic acid ,Environmental Pollutants ,Female ,Caprylates ,Lipoprotein - Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15 years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7 ng/ml in boys and 34.2 and 27.4 ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC (p=0.002) and LDL (p=0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.
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- 2015
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