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Disinfection by UV radiation is one of the most promising solutions to reduce the bacterial load and antibiotic resistance in the final effluents of urban wastewater treatment plants (UWTP). Our aim was to evaluate the fate of cefotaxime-resistant Enterobacteriaceae and Extended Spectrum Beta-Lactamase (ESBL) producers in a full-scale system that includes UV-C disinfection. Over treatment, the abundance of cefotaxime-resistant Enterobacteriaceae was reduced, with reductions of 1.9 log units after secondary treatment (STW samples) and 1.8 log following UV disinfection (UTW samples). These reductions, did not reflect the variations in the prevalence of cefotaxime-resistant Enterobacteriaceae , estimated to be of 3% in raw wastewater (RW), 18% in STW and 3% in UTW. A significant increase of cefotaxime-resistant bacterial counts (0.5 log; p  < 0.05) was observed after 3 days of storage. In a total of 1799 cefotaxime-resistant Enterobacteriaceae isolates, 15% harboured bla CTX-M ( n  = 274), 11% bla TEM ( n  = 194) and 4% bla SHV ( n  = 72). While the ESBL gene prevalence decreased over treatment, the prevalence of the intI 1 gene decreased after ST but slightly increased in UTW samples. The bla CTX-M -carriers were identified as Escherichia coli and Klebsiella pneumoniae , mostly multi-drug resistant (90.5%) and carrying integrase genes (82.8%). The bla CTX-M gene variants (48 bla CTX-M-15 , 9 bla CTX-M-32, 8 bla CTX-M-1, 5 bla CTX-M-27, and 2 bla CTX-M-14 ) were flanked by IS Ecp1 , IS Ecp 1/IS 26 , IS 903 and ORF477 in 8 different arrangements. The IncF plasmid replicon type was highly prevalent among bla CTX-M -carrying Escherichia coli (74.5%) while IncR predominated among K. pneumoniae (54.5%). Our results confirmed the potential of UV-C disinfection to remove antibiotic resistant bacteria. Still, resistant Enterobacteriaceae (about 30 × 10 6  cells per m 3 of water), presenting traits that might potentiate antibiotic resistance spread, are released in the final effluent. In addition, a significant regrowth was observed after storage. These results suggest that improvements of wastewater disinfection are still required to minimize the risks associated with UWTP discharges. [ABSTRACT FROM AUTHOR]