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Your search keyword '"Vijayraghavan S"' showing total 2 results
Start Over Author "Vijayraghavan S" Journal science new york n y
2 results on '"Vijayraghavan S"'

1. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.

Author

Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, and Arnsten AF

Subjects
Adrenergic alpha-Agonists pharmacology, Alkaloids, Animals, Benzophenanthridines, Carbolines pharmacology, Electrophysiology, Enzyme Activation, Female, Imidazoles pharmacology, Lithium Carbonate pharmacology, Macaca mulatta, Male, Memory drug effects, Neurons drug effects, Neurons physiology, Phenanthridines pharmacology, Prefrontal Cortex enzymology, Protein Kinase C antagonists & inhibitors, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, alpha-1 physiology, Signal Transduction, Stress, Physiological physiopathology, Tetradecanoylphorbol Acetate pharmacology, Valproic Acid pharmacology, Memory physiology, Prefrontal Cortex physiology, Protein Kinase C metabolism
Abstract

The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as working memory. We tested the influence of protein kinase C (PKC) intracellular signaling on prefrontal cortical cognitive function and showed that high levels of PKC activity in prefrontal cortex, as seen for example during stress exposure, markedly impair behavioral and electrophysiological measures of working memory. These data suggest that excessive PKC activation can disrupt prefrontal cortical regulation of behavior and thought, possibly contributing to signs of prefrontal cortical dysfunction such as distractibility, impaired judgment, impulsivity, and thought disorder.

Published
2004
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2. Selective D2 receptor actions on the functional circuitry of working memory.

Author

Wang M, Vijayraghavan S, and Goldman-Rakic PS

Subjects
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine pharmacology, Animals, Benzazepines pharmacology, Cues, Dopamine Agonists pharmacology, Dopamine Antagonists pharmacology, Dopamine D2 Receptor Antagonists, Dose-Response Relationship, Drug, Electrophysiology, Macaca mulatta, Male, Psychomotor Performance, Quinpirole pharmacology, Raclopride pharmacology, Receptors, Dopamine D1 agonists, Receptors, Dopamine D1 antagonists & inhibitors, Receptors, Dopamine D1 metabolism, Receptors, Dopamine D2 agonists, Reward, Saccades, Salicylamides pharmacology, Memory physiology, Neurons physiology, Prefrontal Cortex physiology, Receptors, Dopamine D2 metabolism
Abstract

Prefrontal neurons engaged by working memory tasks express a sequence of phasic and tonic activations linked to a train of sensory, mnemonic, and response-related events. Here, we report that the dopamine D2 receptor selectively modulates the neural activities associated with memory-guided saccades in oculomotor delayed-response tasks yet has little or no effect on the persistent mnemonic-related activity, which is instead modulated by D1 receptors. This associates the D2 receptor with a specific component of working memory circuitry and fractionates the modulatory effects of D1 and D2 receptors on the neural machinery of a cognitive process.

Published
2004
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