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2024 OCT 4 (NewsRx) -- By a News Reporter-Staff News Editor at Science Letter -- Data detailed on science have been presented. According to news reporting from the School of [...]

Featuring the lowest dose and the fastest scan speed on the market, Siemens Healthcare's SOMATOM=AE Definition Flash dual-source computed tomography (CT) scanner is now poised to assist Arnold Palmer Hospital [...]

"In a search for novel antileishmanial drugs, we investigated the activity of the calcium channel blocker nimodipine against Leishmania spp. and explored the ultrastructural damages of parasites induced by nimodipine [...]

Micromet, Inc. (NASDAQ:MITI), a biopharmaceutical company focusing on the development of novel, proprietary antibody-based products for cancer, inflammatory and autoimmune diseases, reported final data from the randomized phase 2 clinical [...]

Researchers elucidated that therapeutic drug monitoring for dose individualization of cisplatin (CDDP) in testicular cancer patients is based upon total platinum measurement in plasma. "CDDP is an anticancer agent widely [...]

VioQuest Pharmaceuticals, Inc. (VQPH) announced that it has dosed the first patient in its phase 1/2a clinical trial of VQD-001, sodium stibogluconate (SSG), for evaluation of solid tumors, at the [...]

Wyeth Pharmaceuticals announced that Enbrel (etanercept) is now available in both 25 mg and 50 mg pre-filled syringes (PFS) to treat active rheumatoid arthritis, plaque psoriasis, psoriatic arthritis and ankylosing [...]

In patients with neuropathic pain, pregabalin treatment regimens significantly reduced pain. According to a study from Germany, "The data from a previously published 12-week randomised, double-blind, placebo-controlled multicentre study on [...]

Researchers supported the current once-daily dosing regimen of erlotinib at 150 mg/d in lung cancer patients. According to recent research from the United States, "Our objective was to assess the [...]

A recent study from Denmark has documented the effect of aerosolized rhDNase (Pulmozyme) on pulmonary colonization in patients with cystic fibrosis (CF). "Aerosolized recombinant human deoxyribonuclease (rhDNase I (Pulmozyme) has [...]

Repeated intravitreal triamcinolone injections lose efficacy in diabetic macular edema. According to a study from China, "Intravitreal triamcinolone (IVTA) results in transient improvements in diabetic macular oedema (DMO), necessitating repeated [...]

High-dose propofol during cardiopulmonary bypass (CPB) decreases biochemical markers of myocardial injury in coronary surgery patients. According to a study from the People's Republic of China, "We investigated if increasing [...]

Baxa Corp. and Unit Dose Solutions (UDS) have signed an exclusive co-marketing agreement for promotion of UDS' unique services for hospital pharmacy drug repackaging. Under the agreement, Baxa Corp. will [...]

Continuous monitoring of UV-absorbance allows evaluation of the clearance process during dialysis and gives immediate feedback to on-line adjustments. "An on-line monitoring system for dialysis dose calculations could make it [...]

SciClone Pharmaceuticals, Inc. (SCLN) reported phase 1 data indicating that SCV-07 taken orally was safe and led to circulating plasma concentrations similar to those obtained in previous phase 1 studies [...]

Serono (SEO) and Syntonix Pharmaceuticals Inc. announced that they have entered into an agreement under which the companies will evaluate Syntonix' FSH:Fc SynFusion products for further development. Syntonix' SynFusion and [...]

Hana Biosciences (HNAB), a biopharmaceutical company focused on advancing cancer care, recently provided an update on the company's Talvesta (talotrexin) for Injection clinical program. Hana is conducting multiple clinical trials [...]

Cardiome Pharma Corp. (CRME/COM) announced top-line results from both the 300mg and 600mg dosing groups for its recently-completed Phase 2a pilot study of RSD1235 (oral). The study was initiated in [...]

Two single oral dose gabapentin preparations were bioequivaent in healthy Korean volunteers. Researchers in South Korea conducted a study "to evaluate the bioequivalence of a single oral 400 mg dose [...]

Orexigen Therapeutics, Inc. announced that a positron emission tomography (PET) imaging study of the opioid receptors in the central nervous system demonstrated, for the first time, that it is possible [...]

The recommended dose for treating elderly (greater than or equal to75 years old) patients with small-cell lung cancer (SCLC) was carboplatin of AUC=4 and etoposide of 100 mg/m[superscript]2. According to [...]

VioQuest Pharmaceuticals, Inc. (VQPH), a New Jersey-based biopharmaceutical company, announced that it has dosed the first patient in its phase 1/2a clinical trial of VQD-002, triciribine-phosphate (TCN-P) at the University [...]

Dose escalation of boron neutron capture therapy could improve glioma patient outcome. According to a recent report published in the International Journal of Radiation Oncology Biology Physics, "[the study's aim [...]

Neurocrine Biosciences, Inc. (NBIX) announced positive safety and efficacy results with completion of the second off-treatment 3-month period of its 6-month proof of concept, safety, efficacy and dose-finding phase 2 [...]

Cardiovascular outcomes trials show a significant benefit for high-dose vs. standard-dose statin therapy. According to a recent report from the United States, "The purpose of this study was to conduct [...]

Cardiome Pharma Corp. (CRME; COM) announced top-line results from both the 300mg and 600mg dosing groups for its recently-completed Phase 2a pilot study of RSD1235 (oral). The study was initiated [...]

Hospira, Inc., (HSP), a global hospital products company, announced a new, national agreement with HealthTrust Purchasing Group (HealthTrust) to provide its member organizations access to Hospira's line of pain management [...]

Liponex, Inc., (LPX), a biopharmaceutical company specializing in developing advanced products related to high density lipoprotein (HDL), often called & #147;good cholesterol, & #148; announced that it has initiated patient [...]

Hepatocellular carcinoma (HCC) overall patient survival was not affected after high dose vitamin K3 infusion. "The survival of patients with unresectable advanced HCC with portal vein thrombosis is dismal. Current [...]

King Pharmaceuticals, Inc. (KG) and Depomed, Inc. (DEPO) announced the commercial availability of Glumetza (metformin hydrochloride extended release tablets) in the United States. Glumetza, an oral treatment for type 2 [...]

Memory Pharmaceuticals Corp. (MEMY) announced the dosing of the first subject in a phase 2a trial of MEM 1003 in patients with acute mania in bipolar disorder. The company is [...]

Thyroid cancer patients receiving whole-body I-131 radiotherapy were evaluated for potential absorbed doses. "The evaluation of the absorbed dose from radioactive patients during the treatment of thyroid disease is an [...]

A lower 12 mcg/h dose of fentanyl transdermal delivery system (fentanyl TTS) provided a therapeutic benefit in nonmalignant chronic pain. According to recent research from the United States, "The fentanyl [...]

Naltrexone potentiation of low dose ketamine effects is studied. The potentiation of low dose ketamine effects by naltrexone is studied. According to a study from the United States, "The interplay [...]

The dose of contrast material can be effectively reduced by at least 10% for elderly patients undergoing a multi-detector CT examination of the pancreas and biliary region, a new study [...]

Deletions of the adenomatous polyposis coli (APC) gene, which are otherwise missed by routine mutation analysis, can be detected by gene dose assay. "Familial adenomatous polyposis (FAP) is an autosomal [...]

The appropriate aspirin dose for secondary cardiovascular and cerebrovascular event prevention is examined in a review published in a recent issue of Current Medical Research and Opinion. According to the [...]

T1-T2 prostate cancer patients must be continuously re-examined for risk-group classifications whenever the trend is toward increasing total dose for external beam radiotherapy. According to a study from the United [...]

A nitroglycerin patch dose of 0.2 mg/h showed no measurable ability to increase perfusion to the foot. According to recent research from the United States, "Nitric oxide is an endogenous [...]

Pressurized metered-dose inhalers (pMDIs)should include dose counters as a standard feature. "pMDIs are the cornerstone of asthma treatment. The pMDI is an economic and portable medication delivery system, but the [...]

Intermittent preventive treatment for malaria control administered at the time of routine vaccinations was moderately successful in Mozambican infants. According to report published in the Journal of Infectious Diseases, "There [...]

Schering-Plough reported that results from an ongoing phase 2 clinical trial showed vicriviroc, its investigational CCR5 receptor antagonist, demonstrated potent and sustained viral suppression after 24 weeks of therapy in [...]

Cytokinetics, Incorporated (CYTK) announced the initiation of a Phase I clinical trial evaluating the pharmacokinetic profile of CK-1827452 when administered orally to healthy volunteers. CK-1827452 is a direct cardiac myosin [...]

The 6-mg/24-h selegiline transdermal system can be administered safely without dietary tyramine restrictions. "The oral tyramine pressor test was administered to healthy males during treatment with a selegiline transdermal system [...]

Organ dose estimates were lower than more conservative reference models when calculations were based on actual breast cancer patient population characteristics. "The purpose of this retrospective study was to determine [...]

Critical Therapeutics, Inc. (CRTX) announced the results of its Phase I/II clinical trial designed to evaluate safety, tolerability and pharmacokinetics of the intravenous formulation of zileuton (zileuton IV) in patients [...]

Clinical asthma control and airway inflammation are maintained after switching therapy from medium-dose fluticasone propionate (FP) to low-dose FP. "Inhaled corticosteroids (ICSs) have been shown to reverse epithelial damage and [...]

Dopamine inhibits DNA synthesis in embryonic stem cells in s dose- and time-dependent manner. According to recent research from South Korea, "This study examined the effect of dopamine on DNA [...]

Cancer patients tolerated an oral formulation of irinotecan (CPT-11) administered at a maximum tolerated dose of 80 mg/m[superscript]2/day for 5 days every 3 weeks. "Oral administration of CPT-11 should allow [...]

Intravenous busulfan improves outcomes in non-Hodgkin lymphoma. "Forty-nine patients with intermediate- and high-risk aggressive non-Hodgkin lymphoma underwent autologous hematopoietic stem cell transplantation (autoHSCT) using the regimen of busulfan (Bu), cyclophosphamide [...]