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PD-1 contributes to memory B cell development and robust antibody responses through B cell extrinsic and intrinsic mechanisms.

Programmed death-ligand 1 interacts with fungal ribosomal Rpl20b in phagosomes and induces interleukin-10 secretion.

Xist-containing ribonucleoproteins drive autoimmunity in women.

Insulin-specific B cells called BND2 B cells accumulate in the peripheral blood of patients with very early onset type 1 diabetes.

Cytotoxic CD4 + T cells specific for CMV cull senescent skin fibroblasts.

Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell-dependent elimination of infected cells (see related Research Article by Irrgang et al .).

A conditional knockout system permitting deletion of ILC2 cells reveals non-redundant roles in eosinophil recruitment and helminth clearance.

During pregnancy, sialic acid on Listeria monocytogenes antibodies can be deacetylated, sanctioning these antibodies to mediate protection in the newborn.

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A human autoimmune and allergic disease susceptibility variant on chromosome 11 results in the reduced expression of the gene encoding the GARP protein and thus compromises the function of regulatory T cells., (Copyright © 2020, American Association for the Advancement of Science.)

T cells that target β-synuclein induce damage to the gray matter of the brain in multiple sclerosis and contribute to neurodegeneration., (Copyright © 2019, American Association for the Advancement of Science.)

Genomic biomarkers will help to elucidate which cancer patients will benefit from PD-1 blockade immunotherapy., (Copyright © 2018, American Association for the Advancement of Science.)

CD8 + T cells formed early in life respond more rapidly to infection, and this appears to be the result of a pre-programmed effector-like chromatin landscape., (Copyright © 2018, American Association for the Advancement of Science.)

Engineered cytokines are able to improve immunotherapy in mouse tumor models., (Copyright © 2018, American Association for the Advancement of Science.)

Transcriptomic studies reveal defective costimulation via PD-L1 to explain the autoreactive phenotype seen in type 1 diabetes mellitus., (Copyright © 2018, American Association for the Advancement of Science.)

A two-cell type CRISPR screen has identified genes and pathways that mediate resistance to cancer immunotherapy., (Copyright © 2017, American Association for the Advancement of Science.)

Sestrins drive immune senescence, and their inhibition may restore immunity in the elderly and improve vaccine responses., (Copyright © 2017, American Association for the Advancement of Science.)

Mutation-associated infections in one individual are prevented in relatives with the same mutation by a compensatory adaptive immune response., (Copyright © 2017, American Association for the Advancement of Science.)