1. MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
- Author
-
Vondrakova, Jana, Frolikova, Michaela, Ded, Lukas, Cerny, Jiri, Postlerova, Pavla, Palenikova, Veronika, Simonik, Ondrej, Nahacka, Zuzana, Basus, Krystof, Valaskova, Eliska, Machan, Radek, Pacey, Allan, Holubcova, Zuzana, Koubek, Pavel, Ezrova, Zuzana, Park, Soojin, Liu, Ruiwu, Partha, Raghavendran, Clark, Nathan, Neuzil, Jiri, Ikawa, Masahito, Erickson, Kent, Lam, Kit S, Moore, Harry, and Komrskova, Katerina
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,Biotechnology ,Contraception/Reproduction ,5.2 Cellular and gene therapies - Abstract
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
- Published
- 2022